Recent advances in understanding the role of FOXO3

Stefanetti, Renae J.; Voisin, Sarah; Russell, Aaron P.; Lamon, Séverine

doi:10.12688/f1000research.15258.1

Cited by 69 publications

(66 citation statements)

References 82 publications

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“…This upregulation is in agreement with previous reports [28,29]. In addition, we investigated the expression of FOXO3 as it has a significant regulatory role in cellular aging process as well as antioxidant response [30][31][32][33]. FOXO3 was upregulated upon treatment with ACCB with or without H 2 O 2 treatment of NHDF cells.…”

Section: Discussionsupporting

confidence: 90%

Marine Fungus Aspergillus chevalieri TM2-S6 Extract Protects Skin Fibroblasts from Oxidative Stress

Letsiou¹,

Bakea²,

Goff

et al. 2020

Marine Drugs

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The strain Aspergillus chevalieri TM2-S6 was isolated from the sponge Axinella and identified according to internal transcribed spacer (ITS) molecular sequence homology with Aspergillus species from the section Restricti. The strain was cultivated 9 days on potato dextrose broth (PDB), and the medium evaluated as antioxidant on primary normal human dermal fibroblasts (NHDF). The cultivation broth was submitted to sterile filtration, lyophilized and used without any further processing to give the Aspergillus chevalieri TM2-S6 cultivation broth ingredient named ACBB. ACCB contains two main compounds: tetrahydroauroglaucin and flavoglaucin. Under oxidative stress, ACCB showed a significant promotion of cell viability. To elucidate the mechanism of action, the impact on a panel of hundreds of genes involved in fibroblast physiology was evaluated. Thus, ACCB stimulates cell proliferation (VEGFA, TGFB3), antioxidant response (GPX1, SOD1, NRF2), and extracellular matrix organization (COL1A1, COL3A1, CD44, MMP14). ACCD also reduced aging (SIRT1, SIRT2, FOXO3). These findings indicate that Aspergillus chevalieri TM2-S6 cultivation broth exhibits significant in vitro skin protection of human fibroblasts under oxidative stress, making it a potential cosmetic ingredient.

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Section: Discussionsupporting

confidence: 90%

Marine Fungus Aspergillus chevalieri TM2-S6 Extract Protects Skin Fibroblasts from Oxidative Stress

Letsiou¹,

Bakea²,

Goff

et al. 2020

Marine Drugs

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“…A single gene can generate multiple circRNAs, either with a high copy number, of different sizes (e.g., PTK2 gene can produce 47 distinct circRNAs) (Zheng et al, 2016), or in a combination of both possibilities. As already observed, a single circRNA can be expressed in various tissues (e.g., circHIPK3- Li et al, 2017;Ni et al, 2019) and can possess binding sites for multiple distinct miRNAs (e.g., circFOXO3- Han et al, 2017;Stefanetti et al, 2018). Considering all the cases mentioned above, a single circRNA can bind to multiple distinct miRNAs that regulate different pathways and vice versa, which is proof of a network that functions interdependently to maintain cellular homeostasis.…”

Section: Mirna Spongingmentioning

confidence: 60%

“…The diverse mechanism behind the action of the tumor suppressor gene-derived circFOXO3 in cell cycle regulation has been studied. Having binding sites for miR-22, miR-96, miR-136, miR-138, miR-149, miR-433, miR-762, miR-3614-5p, and miR-3622b-5p (Han et al, 2017;Stefanetti et al, 2018), circFOXO3 sponges these miRNAs from binding the linear variant of FOXO3 and relieves its suppression. Besides having miRNA binding sites, circFOXO3 has binding sites for proteins involved in cell cycle regulation, such as p21, p27, p53, CDK-2, and MDM2.…”

Section: Cell Cycle Regulationmentioning

confidence: 99%

Circular RNAs—The Road Less Traveled

Guria

Sharma

Natesan

et al. 2020

Front. Mol. Biosci.

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Circular RNAs are the most recent addition in the non-coding RNA family, which has started to gain recognition after a decade of obscurity. The first couple of reports that emerged at the beginning of this decade and the amount of evidence that has accumulated thereafter has, however, encouraged RNA researchers to navigate further in the quest for the exploration of circular RNAs. The joining of 5 ′ and 3 ′ ends of RNA molecules through backsplicing forms circular RNAs during co-transcriptional or post-transcriptional processes. These molecules are capable of effectively sponging microRNAs, thereby regulating the cellular processes, as evidenced by numerous animal and plant systems. Preliminary studies have shown that circular RNA has an imperative role in transcriptional regulation and protein translation, and it also has significant therapeutic potential. The high stability of circular RNA is rendered by its closed ends; they are nevertheless prone to degradation by circulating endonucleases in serum or exosomes or by microRNA-mediated cleavage due to their high complementarity. However, the identification of circular RNAs involves diverse methodologies and the delineation of its possible role and mechanism in the regulation of cellular and molecular architecture has provided a new direction for the continuous research into circular RNA. In this review, we discuss the possible mechanism of circular RNA biogenesis, its structure, properties, degradation, and the growing amount of evidence regarding the detection methods and its role in animal and plant systems.

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“…This tolerance relies heavily on mechanisms that are absent in vertebrates (e.g., trehalose synthesis, glyoxylate shunt activation, LEA proteins) and that, at least partially, contribute to daf-2 longevity. Even though the FoxO transcription factors have been linked to human longevity, the underlying mechanisms by which this is achieved could differ substantially between worms and humans due to differences in the details of their physiology, organismal complexity, and environmental challenges these organisms face in nature [153,154].…”

Section: The Metabolism In Daf-2 Mutants Is Extensively Remodeledmentioning

confidence: 99%

DAF-16/FoxO in Caenorhabditis elegans and Its Role in Metabolic Remodeling

Zecic

Braeckman

2020

Cells

103

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DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional changes in many genes involved in aging, development, stress, metabolism, and immunity. The major regulator of DAF-16 activity is the insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) pathway, reduction of which leads to lifespan extension in worms, flies, mice, and humans. In C. elegans daf-2 mutants, reduced IIS leads to a heterochronic activation of a dauer survival program during adulthood. This program includes elevated antioxidant defense and a metabolic shift toward accumulation of carbohydrates (i.e., trehalose and glycogen) and triglycerides, and activation of the glyoxylate shunt, which could allow fat-to-carbohydrate conversion. The longevity of daf-2 mutants seems to be partially supported by endogenous trehalose, a nonreducing disaccharide that mammals cannot synthesize, which points toward considerable differences in downstream mechanisms by which IIS regulates aging in distinct groups.

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Recent advances in understanding the role of FOXO3

Cited by 69 publications

References 82 publications

Marine Fungus Aspergillus chevalieri TM2-S6 Extract Protects Skin Fibroblasts from Oxidative Stress

Marine Fungus Aspergillus chevalieri TM2-S6 Extract Protects Skin Fibroblasts from Oxidative Stress

Circular RNAs—The Road Less Traveled

DAF-16/FoxO in Caenorhabditis elegans and Its Role in Metabolic Remodeling

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