2019
DOI: 10.12688/f1000research.17471.1
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Abstract: Metalloproteinases remain important players in arthritic disease, in part because members of this large enzymatic family, namely matrix metalloproteinase-1 (MMP-1) and MMP-13, are responsible for the irreversible degradation of articular cartilage collagen. Although direct inhibition of MMPs fell out of vogue with the initial clinical disappointment of the first generation of compounds, interest in other mechanisms that control these important enzymes has always been maintained. Since these enzymes are critica… Show more

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Cited by 38 publications
(33 citation statements)
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References 116 publications
(130 reference statements)
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“…Among them, MMP-13 (collagenase 3) is an enzyme constitutively expressed in the chondrocyte that degrades collagenous ECM [ 15 ]. However, its aberrant expression and activity elicited by pro-inflammatory mediators and oxidative stress has been associated with diseases such as OA [ 15 , 16 , 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…Among them, MMP-13 (collagenase 3) is an enzyme constitutively expressed in the chondrocyte that degrades collagenous ECM [ 15 ]. However, its aberrant expression and activity elicited by pro-inflammatory mediators and oxidative stress has been associated with diseases such as OA [ 15 , 16 , 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…Some of them, such as Batimastat (BB-94), Marimastat (BB-2516), Prinomastat (AG-3340), Tanomastat (BAY12-9566) and MMI 270 B (CGS 27023 A), are associated with severe musculoskeletal side-effects. These effects are present in the form of osteoarthritis and are attributed to the degradation of MMP-1 and -13 [35]. Metastat (COL-3, CMT-3) was shown to be beneficial against nonepithelial-type malignancy and is currently under a phase II trial.…”
Section: Introductionmentioning
confidence: 99%
“…Increased expression of PTCRA, TNFSF10, HEY2 genes stimulated by curcumin may facilitate cellular protection and maintenance of the first trimester placental cells. Matrix metalloproteinases (MMPs) play a central role in several biological processes such as embryogenesis, tissue remodeling, migration, and angiogenesis (Young et al, 2019). Expression of MMP2, MMP9 was increased in the presence of curcumin in HTR8/SVneo cells supports the angiogenic effects of curcumin.…”
Section: Discussionmentioning
confidence: 99%
“…Expression of MMP2, MMP9 was increased in the presence of curcumin in HTR8/SVneo cells supports the angiogenic effects of curcumin. HSD11β2 is extensively expressed in the term placenta (Young et al, 2019). However, the impact of lowering of HSD11β2 by curcumin in early placentation needs further investigation…”
Section: Discussionmentioning
confidence: 99%