Recent advances in the role of neutrophils and neutrophil extracellular traps in acute pancreatitis

Ishqi, Hassan Mubarak; Ali, Misha; Dawra, Rajinder

doi:10.1007/s10238-023-01180-4

Cited by 2 publications

(1 citation statement)

References 184 publications

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“…Acute pancreatitis (AP) is an acute inflammatory condition of the pancreas characterized by high prevalence and varying degrees of severity, which can pose life-threatening risks. [ 1 – 3 ] Globally, it manifests annually in approximately 30 per 100,000 individuals. [ 4 ] Severe cases of AP exhibit mortality rates ranging between 15% and 30%, often attributed to extensive pancreatic tissue necrosis, systemic inflammatory response syndrome, persistent organ failure, subsequent infections, and the absence of specific treatments.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic performance of acoustic radiation force impulse for acute pancreatitis: A meta-analysis

Wang,

Zhang,

Feng

2024

Medicine

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Objective: The objective of this meta-analysis is to evaluate the diagnostic performance of acoustic radiation force impulse (ARFI) in acute pancreatitis (AP) patients. Methods: PubMed, Web of Science, Embase, Wanfang, Chinese Biological Medicine databases, and Chinese Biomedical Literature Service System were searched for relevant studies to explore the potential diagnostic performance of ARFI in AP from inception to November 2023. STATA 14.0 was used to analyze the standardized mean difference (SMD) with 95% confidence interval (CI), pooled sensitivity, specificity, area under the curve, meta-regression analysis, sensitivity analysis, and publication bias. Results: Nine studies, involving 533 AP patients and 585 healthy controls, were included. AP patients had significantly higher ARFI levels than healthy controls (SMD: 3.13, 95% CI: 1.88–4.39, P = .001). The area under the curve of ARFI for diagnosing AP was 0.99 (95% CI: 0.98–1.00), with 98% sensitivity and 94% specificity. Meta-regression identified the study region and study period as the sources of heterogeneity. Sensitivity analysis showed that the exclusion of any single study did not materially alter the overall combined effect. No evidence of publication bias was observed in the included studies. Conclusion: This meta-analysis demonstrated that ARFI exerted satisfactory diagnostic performance in AP.

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Section: Introductionmentioning

confidence: 99%

Diagnostic performance of acoustic radiation force impulse for acute pancreatitis: A meta-analysis

Wang,

Zhang,

Feng

2024

Medicine

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Neutrophil extracellular traps and their implications in airway inflammatory diseases

Xuan,

Zhao,

Kang

et al. 2024

Front. Med.

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Neutrophil extracellular traps (NETs) are essential for immune defense and have been increasingly recognized for their role in infection and inflammation. In the context of airway inflammatory diseases, there is growing evidence suggesting the involvement and significance of NETs. This review aims to provide an overview of the formation mechanisms and components of NETs and their impact on various airway inflammatory diseases, including acute lung injury/ARDS, asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. By understanding the role of NETs in airway inflammation, we can gain valuable insights into the underlying pathogenesis of these diseases and identify potential targets for future therapeutic strategies that either target NETs formation or modulate their harmful effects. Further research is warranted to elucidate the complex interactions between NETs and airway inflammation and to develop targeted therapies that can effectively mitigate their detrimental effects while preserving their beneficial functions in host defense.

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Recent advances in the role of neutrophils and neutrophil extracellular traps in acute pancreatitis

Cited by 2 publications

References 184 publications

Diagnostic performance of acoustic radiation force impulse for acute pancreatitis: A meta-analysis

Diagnostic performance of acoustic radiation force impulse for acute pancreatitis: A meta-analysis

Neutrophil extracellular traps and their implications in airway inflammatory diseases

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