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Cited by 37 publications
(40 citation statements)
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References 29 publications
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“…In our study, the effect of POH alone was much smaller than the chemoprevention effect of POH reported in other animal models of cancer (33,34). However, our studies used low doses of POH because high doses of POH that were effective in animal models induced extreme gastroenterotoxicity when applied in humans (23 An obvious question is how POH relieves the protein translational block of mda-7/IL-24 in pancreatic cancer cells infected with Ad.mda-7. Ongoing experiments are elucidating the mechanism underlying this profound synergy between POH and mda-7/IL-24 in pancreatic carcinoma cells.…”
Section: Resultsmentioning
confidence: 53%
See 1 more Smart Citation
“…In our study, the effect of POH alone was much smaller than the chemoprevention effect of POH reported in other animal models of cancer (33,34). However, our studies used low doses of POH because high doses of POH that were effective in animal models induced extreme gastroenterotoxicity when applied in humans (23 An obvious question is how POH relieves the protein translational block of mda-7/IL-24 in pancreatic cancer cells infected with Ad.mda-7. Ongoing experiments are elucidating the mechanism underlying this profound synergy between POH and mda-7/IL-24 in pancreatic carcinoma cells.…”
Section: Resultsmentioning
confidence: 53%
“…POH blocks several signaling pathways, such as ras, extracellular signal-regulated kinase, and nuclear factornB, and prevents the isoprenylation of the Ras family of small GTPase proteins (19 -23). The pharmacokinetics of POH has been defined in both murine models and humans (24,25) and phase I and II clinical trials have revealed that POH is well tolerated (23,26). We now confirm for the first time that POH has significant chemopreventive effects for pancreatic cancer, and a chemoprevention plus gene therapy (CGT) protocol, involving a combination of POH with Ad.mda-7, efficiently eliminated both s.c. and i.p.…”
Section: Introductionmentioning
confidence: 99%
“…A ativação das proteínas Ras leva a uma cascata de fosforilações envolvendo serina e treonina-cinases como RAF e cinases ativadas por mitógenos (MAPK), que são responsáveis pela fosforilação de uma variedade de proteínas citosólicas e nucleares, incluindo outras proteínas cinases e fatores de transcrição 4 . Nosso grupo demonstrou que o monoterpeno álcool perílico tem efeitos na proliferação celular, na migração, na angiogênese e induz apoptose em linhagens celulares e células de explantes de gliomas malignos 15 . Também foram observadas, por meio de eletroforese unidimensional, proteínas expressas diferencialmente nas células tratadas com álcool perílico quando comparadas com células-controle 14 .…”
Section: Discussionunclassified
“…90,91 The detailed pharmacokinetics and toxicity of this agent is already understood in both animals and humans. 92,93 Earlier studies by several groups showed chemotherapeutic effects of POH in animal models (rat and hamster) of liver and pancreatic cancer. 94,95 In the majority of these experiments, animals were subjected to POH treatment after tumors developed.…”
Section: Mda-7/il-24 Facilitates the Chemo-preventive Efficacy Of Diementioning
confidence: 99%
“…These studies used low doses of POH because high doses of POH that were effective in animal models induced extreme gastroenterotoxicity when applied in humans. 92 POH treatment even at low doses significantly augmented gene therapy by making inherently resistant pancreatic carcinoma cells sensitive to Ad.mda-7 therapy. Subsequent detailed mechanistic studies indicated that the generation of reactive oxygen species mediated by xanthine oxidase, a major source of superoxide radical production, by POH in combination with Ad.mda-7 was a significant contributory factor in the cancer-specific toxicity (Fig.…”
Section: Mda-7/il-24 Facilitates the Chemo-preventive Efficacy Of Diementioning
confidence: 99%