Recent advances in the molecular mechanisms of low-intensity pulsed ultrasound against inflammation

Li, Xueke; Zhong, Yi; Zhang, Li; Xie, Mingxing

doi:10.1007/s00109-023-02302-x

Cited by 9 publications

(3 citation statements)

References 125 publications

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“… 42 , 111 The most recent research has reported that LIPUS can significantly reduce the expression of pro‐inflammatory cytokines and contribute to the modulation of the immune microenvironment in vivo. 122 , 123 , 124 , 125 In alignment with these findings, the application of LIPUS to MSC‐Exo reinforces their anti‐inflammatory effects via altering the compositions of MSC‐Exo. 31 , 111 …”

Section: Effects Of Different Physical Factors On Msc‐exosupporting

confidence: 54%

Physical modulation of mesenchymal stem cell exosomes: A new perspective for regenerative medicine

Wu,

Zhao,

Xie

et al. 2024

Cell Proliferation

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Mesenchymal stem cell‐derived exosomes (MSC‐Exo) offer promising therapeutic potential for various refractory diseases, presenting a novel therapeutic strategy. However, their clinical application encounters several obstacles, including low natural secretion, uncontrolled biological functions and inherent heterogeneity. On the one hand, physical stimuli can mimic the microenvironment dynamics where MSC‐Exo reside. These factors influence not only their secretion but also, significantly, their biological efficacy. Moreover, physical factors can also serve as techniques for engineering exosomes. Therefore, the realm of physical factors assumes a crucial role in modifying MSC‐Exo, ultimately facilitating their clinical translation. This review focuses on the research progress in applying physical factors to MSC‐Exo, encompassing ultrasound, electrical stimulation, light irradiation, intrinsic physical properties, ionizing radiation, magnetic field, mechanical forces and temperature. We also discuss the current status and potential of physical stimuli‐affected MSC‐Exo in clinical applications. Furthermore, we address the limitations of recent studies in this field. Based on this, this review provides novel insights to advance the refinement of MSC‐Exo as a therapeutic approach in regenerative medicine.

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Section: Effects Of Different Physical Factors On Msc‐exosupporting

confidence: 54%

Physical modulation of mesenchymal stem cell exosomes: A new perspective for regenerative medicine

Wu,

Zhao,

Xie

et al. 2024

Cell Proliferation

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“…During the initial inflammatory phase of 2 postoperative weeks, the bone-tendon junction healed more quickly in the LIPUS group than the control group. The prominent relieving effect of LIPUS on local inflammation was validated by decreased mRNA expression of proinflammatory cytokines and increased anti-inflammatory cytokines of patella-patellar tendon complexes [140][141][142]. Additionally, further study showed that LIPUS initiated during postoperative week 1 had a more noticeable effect on bone-tendon healing compared to immediate postoperative healing and postoperative week 2 [143].…”

Section: Lipus Parametersmentioning

confidence: 94%

Musculoskeletal Biomaterials: Stimulated and Synergized with Low Intensity Pulsed Ultrasound

Jia,

Zhou,

Zhan

2023

JFB

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Clinical biophysical stimulating strategies, which have significant effects on improving the function of organs or treating diseases by causing the salutary response of body, have shown many advantages, such as non-invasiveness, few side effects, and controllable treatment process. As a critical technique for stimulation, the low intensity pulsed ultrasound (LIPUS) has been explored in regulating osteogenesis, which has presented great promise in bone repair by delivering a combined effect with biomaterials. This review summarizes the musculoskeletal biomaterials that can be synergized with LIPUS for enhanced biomedical application, including bone regeneration, spinal fusion, osteonecrosis/osteolysis, cartilage repair, and nerve regeneration. Different types of biomaterials are categorized for summary and evaluation. In each subtype, the verified biological mechanisms are listed in a table or graphs to prove how LIPUS was effective in improving musculoskeletal tissue regeneration. Meanwhile, the acoustic excitation parameters of LIPUS that were promising to be effective for further musculoskeletal tissue engineering are discussed, as well as their limitations and some perspectives for future research. Overall, coupled with biomimetic scaffolds and platforms, LIPUS may be a powerful therapeutic approach to accelerate musculoskeletal tissue repair and even in other regenerative medicine applications.

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“…По данным литературы, низкочастотное ультразвуковое кавитационное орошение носоглотки является одним из безопасных и эффективных физических способов лечения аденоидита [32,41]. При углубленном исследовании физических свой ств и особенностей такого орошения поврежденных тканей был обнаружен противовоспалительный эффект, основной механизм которого связан с изменением цитокинов и сигнальных путей в очаге воспаления, повышением фагоцитарной активности лейкоцитов и уровня неспецифической защиты клеток [42][43][44][45]. Исходя из этого, определенный научный интерес представляет собой изучение в комбинации бесконтактного орошения тканей и слизистых обработанными НУЗ водными растворами с присутствием процесса кавитации (далее НУЗ кавитационным орошением) и ФХТ в лечении ХА.…”

Section: Introductionunclassified

Chronic adenoiditis and its effect on the reactivity of the bronchopulmonary system, the possibility of non-drug correction

Korkmazov,

Solodovnik,

Kornova

et al. 2024

Medicinskij sovet

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Introduction. In pediatric otorhinolaryngological practice, chronic adenoiditis is one of the most common diseases and causes the search for additional and effective methods of treatment.Aim. To evaluate the clinical effectiveness of the use of aqueous solutions treated with low-frequency ultrasound with high specific energy and monochromatic light radiation in the complex therapy of chronic adenoiditis in children.Materials and methods. The number of participants in the study was 104 patients aged 4 to 15 years with a verified diagnosis of chronic adenoiditis and were divided into 3 groups depending on the treatment. A comparative analysis of the results obtained was carried out before the start of therapy (day 0) and on the 7th day after the treatment. The state of the nasopharynx was assessed using a flexible nasopharyngoscope, as well as the structure of the middle ear and auditory tube during acoustic impedancemetry.Results. The use of a course of treatment of low-frequency ultrasonic cavitation in combination with photochromotherapy made it possible to relieve the signs of chronic adenoiditis in 62% of cases (p < 0.001), reduce the number of patients with grade III adenoid hypertrophy by 54% (p = 0.035), and reduce by 2 times (p = 0.05) number of relapses of chronic adenoiditis. In the group of children using low-frequency ultrasonic cavitation, the positive effect of treatment was 3.3 times [CI 0.75; 14.6] higher compared to the control group, and in combination with photochromotherapy it was 3.6 times [CI 0.85; 15.5]. The absence of adenotomy was assessed as a positive effect.Conclusion. The data obtained showed that the inclusion of non-drug methods of physical influence (low-frequency ultrasonic cavitation both in monotherapy and in combination with photochromotherapy) in complex treatment can reduce the number of surgical interventions on the organs of the lymphopharyngeal ring – the pharyngeal tonsil.

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Recent advances in the molecular mechanisms of low-intensity pulsed ultrasound against inflammation

Cited by 9 publications

References 125 publications

Physical modulation of mesenchymal stem cell exosomes: A new perspective for regenerative medicine

Physical modulation of mesenchymal stem cell exosomes: A new perspective for regenerative medicine

Musculoskeletal Biomaterials: Stimulated and Synergized with Low Intensity Pulsed Ultrasound

Chronic adenoiditis and its effect on the reactivity of the bronchopulmonary system, the possibility of non-drug correction

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