Recent advances in the development of 225Ac- and 211At-labeled radioligands for radiotheranostics
Masayuki Munekane,
Takeshi Fuchigami,
Kazuma Ogawa
Abstract:Radiotheranostics utilizes a set of radioligands incorporating diagnostic or therapeutic radionuclides to achieve both diagnosis and therapy. Imaging probes using diagnostic radionuclides have been used for systemic cancer imaging. Integration of therapeutic radionuclides into the imaging probes serves as potent agents for radionuclide therapy. Among them, targeted alpha therapy (TAT) is a promising next-generation cancer therapy. The α-particles emitted by the radioligands used in TAT result in a high linear … Show more
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