Recent advances in stimuli-responsive polymer systems for remotely controlled drug release

Zhang, Aitang; Jung, Kenward; Li, Aihua; Liu, Jingquan; Boyer, Cyrille

doi:10.1016/j.progpolymsci.2019.101164

Cited by 205 publications

(113 citation statements)

References 142 publications

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“…PNIPAM chains undergo a phase transition in water from a swollen to collapsed dehydrated state while heating above 32 • C (LCST-lower critical solution temperature) that is related to breaking of hydrogen bonds. These conformational changes of PNIPAM were firstly observed by Heskins and Guillet [38] and later broadly studied and applied both in solutions and for surface grafted macromolecules [39,40]. This behavior of PNIPAM enables the fabrication of various porous and nonporous materials decorated with the polymer chains for e.g., temperature-triggered gating of pores or controlled adsorption/desorption leading to so-called "smart" surfaces [41][42][43][44].…”

Section: Introductionmentioning

confidence: 85%

Thermoresponsive Polymer Gating System on Mesoporous Shells of Silica Particles Serving as Smart Nanocontainers

2020

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Spherical silica nanoparticles with solid cores and mesoporous shells (SCMS) were decorated with thermoresponsive polymer brushes that were shown to serve as macromolecular valves to control loading and unloading of a model dye within the mesopores. Thermoresponsive poly(N-isopropylacrylamide) (PNIPAM) brushes were grafted from the surfaces of both solid core (SC) and SCMS particles of similar size using surface-initiated atom transfer radical polymerization. Both systems based on porous (SCMS-PNIPAM) and nonporous (SC-PNIPAM) particles were characterized using cryo-TEM, thermogravimetry and elemental analysis to determine the structure and composition of the decorated nanoparticles. The grafted PNIPAM brushes were found to be responsive to temperature changes enabling temperature-controlled gating of the pores. The processes of loading and unloading in the obtained systems were examined using a model fluorescent dye—rhodamine 6G. Polymer brushes in SCMS-PNIPAM systems were shown to serve as molecular valves enabling significant adsorption (loading) of the dye inside the pores with respect to the SC-PNIPAM (no pores) and SCMS (no valves) systems. The effective unloading of the fluorescent cargo molecules from the decorated nanoparticles was achieved in a water/methanol solution. The obtained SCMS-PNIPAM particles may be used as smart nanocontainers or nanoreactors offering also facile isolation from the suspension due to the presence of dense cores.

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Section: Introductionmentioning

confidence: 85%

Thermoresponsive Polymer Gating System on Mesoporous Shells of Silica Particles Serving as Smart Nanocontainers

2020

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“…These materials are designed to recognize a specific environmental stimulus and respond to it in a specific way, generally with the material returning to the original state in the absence of the stimulus [ 1 , 2 ]. One promising application of smart polymer materials is in the control of cargo delivery at the nanoscale, ranging from drug delivery to catalysis, corrosion control and so forth [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Grafting with RAFT—gRAFT Strategies to Prepare Hybrid Nanocarriers with Core-shell Architecture

et al. 2020

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Stimuli-responsive polymer materials are used in smart nanocarriers to provide the stimuli-actuated mechanical and chemical changes that modulate cargo delivery. To take full advantage of the potential of stimuli-responsive polymers for controlled delivery applications, these have been grafted to the surface of mesoporous silica particles (MSNs), which are mechanically robust, have very large surface areas and available pore volumes, uniform and tunable pore sizes and a large diversity of surface functionalization options. Here, we explore the impact of different RAFT-based grafting strategies on the amount of a pH-responsive polymer incorporated in the shell of MSNs. Using a “grafting to” (gRAFT-to) approach we studied the effect of polymer chain size on the amount of polymer in the shell. This was compared with the results obtained with a “grafting from” (gRAFT-from) approach, which yield slightly better polymer incorporation values. These two traditional grafting methods yield relatively limited amounts of polymer incorporation, due to steric hindrance between free chains in “grafting to” and to termination reactions between growing chains in “grafting from.” To increase the amount of polymer in the nanocarrier shell, we developed two strategies to improve the “grafting from” process. In the first, we added a cross-linking agent (gRAFT-cross) to limit the mobility of the growing polymer and thus decrease termination reactions at the MSN surface. On the second, we tested a hybrid grafting process (gRAFT-hybrid) where we added MSNs functionalized with chain transfer agent to the reaction media containing monomer and growing free polymer chains. Our results show that both modifications yield a significative increase in the amount of grafted polymer.

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“…Taking the application in the photovoltaic cell as an example, we showed the advantages of materials tuned by nano tuners. The results can be easily transplanted to numerous other elds, such as catalysis (include solar fuels, articial photosynthesis and photocatalysis), 24 electroluminescence, [25][26][27] mechanoluminescence, 28 thermoelectricity 29 lithium batteries, hydrogen storage, 30 superconductivity, 31 magnetic materials, 32 and drugs, 33 since numerous studies have shown applications of strain on them. For example, aggregation-induced emission (AIE) 34 and clusteroluminescence 35 would have a new tool if a nano tuner was introduced because the two phenomena are the direct results of intermolecular interaction.…”

Section: Discussionmentioning

confidence: 99%

A universal strategy to continuously tune the properties of materials through internal strain

Liu

2020

RSC Adv.

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Recent advances in stimuli-responsive polymer systems for remotely controlled drug release

Cited by 205 publications

References 142 publications

Thermoresponsive Polymer Gating System on Mesoporous Shells of Silica Particles Serving as Smart Nanocontainers

Thermoresponsive Polymer Gating System on Mesoporous Shells of Silica Particles Serving as Smart Nanocontainers

Grafting with RAFT—gRAFT Strategies to Prepare Hybrid Nanocarriers with Core-shell Architecture

A universal strategy to continuously tune the properties of materials through internal strain

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