Recent advances in radical-mediated intermolecular (4 + 2) cycloaddition

Abstract

(4+2) cycloaddition plays an important role in the synthesis of versatile carbocyclic/heterocyclic compounds with its high atom and step economy. Additionally, with mild condition and indispensable functional group compatibility, the...

Visible-light-enabled stereoselective synthesis of functionalized cyclohexylamine derivatives via [4 + 2] cycloadditions

“…The [4 + 2] cycloaddition is appreciated as a powerful synthetic tool to prepare valuable cycloalkane derivatives. 2 The inherent ring-strain release of small-ring compounds serving as 1, n -synthons has been exploited as a powerful driving strategy through the cleavage of typically unreactive bonds, which has resulted in the wide use of these versatile molecules in organic synthesis. 3 Among such small-ring compounds, the ring opening of cyclobutanes is generally less studied than that of cyclopropanes because of their smaller ring tensile force and slower ring-opening rate, 4 but they could work as four-carbon synthons to prepare a diverse array of organic compounds to greatly broaden their use in organic synthesis.…”