Recent advances in polymeric transdermal drug delivery systems

Sabbagh, Farzaneh; Kim, Beom Soo

doi:10.1016/j.jconrel.2021.11.025

Cited by 180 publications

(116 citation statements)

References 146 publications

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“…Low oral bioavailability and side effects restricted oral administration of most drugs with poor solubility in clinical use [ 30 ]. However, there are a lot of medicines that implementation by the oral route is characterized by a low adsorption rate from the gastrointestinal tract or extensive first-pass metabolism [ 32 , 33 ]. In these examples, the skin may be an alternative route for applying drugs, as it has been widely used as a route of administration for local and systemic drugs [ 34 , 35 ].…”

Section: Mip Challenges In Transdermal Deliverymentioning

confidence: 99%

Molecularly Imprinted Polymers as State-of-the-Art Drug Carriers in Hydrogel Transdermal Drug Delivery Applications

Lusina

Cegłowski

2022

Polymers

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Molecularly Imprinted Polymers (MIPs) are polymeric networks capable of recognizing determined analytes. Among other methods, non-covalent imprinting has become the most popular synthesis strategy for Molecular Imprinting Technology (MIT). While MIPs are widely used in various scientific fields, one of their most challenging applications lies within pharmaceutical chemistry, namely in therapeutics or various medical therapies. Many studies focus on using hydrogel MIPs in transdermal drug delivery, as the most valuable feature of hydrogels in their application in drug delivery systems that allow controlled diffusion and amplification of the microscopic events. Hydrogels have many advantages over other imprinting materials, such as milder synthesis conditions at lower temperatures or the increase in the availability of biological templates like DNA, protein, and nucleic acid. Moreover, one of the most desirable controlled drug delivery applications is the development of stimuli-responsive hydrogels that can modulate the release in response to changes in pH, temperature, ionic strength, or others. The most important feature of these systems is that they can be designed to operate within a particular human body area due to the possibility of adapting to well-known environmental conditions. Therefore, molecularly imprinted hydrogels play an important role in the development of modern drug delivery systems.

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Section: Mip Challenges In Transdermal Deliverymentioning

confidence: 99%

Molecularly Imprinted Polymers as State-of-the-Art Drug Carriers in Hydrogel Transdermal Drug Delivery Applications

Lusina

Cegłowski

2022

Polymers

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“…The released ingredients should directly attach to the surface of skin for better care if a wet CS/γ-PGA/DOE hydrogel were to be covered on skin. Therefore, the hydrogel will be also potentially extended in the administration of transdermal delivery, which has proven to be one of the most favorable methods among novel drug delivery systems [ 67 ].…”

Section: Resultsmentioning

confidence: 99%

Dendrobium officinale Enzyme Changing the Structure and Behaviors of Chitosan/γ-poly(glutamic acid) Hydrogel for Potential Skin Care

Wang

Zhang

et al. 2022

Polymers

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Hydrogels have been widespreadly used in various fields. But weak toughness has limited their further applications. In this study, Dendrobium officinale enzyme (DOE) was explored to improve chitosan/γ-poly(glutamic acid) (CS/γ-PGA) hydrogel in the structure and properties. The results indicated that DOE with various sizes of ingredients can make multiple noncovalent crosslinks with the skeleton network of CS/γ-PGA, significantly changing the self-assembly of CS/γ-PGA/DOE hydrogel to form regular protuberance nanostructures, which exhibits stronger toughness and better behaviors for skin care. Particularly, 4% DOE enhanced the toughness of CS/γ-PGA/DOE hydrogel, increasing it by 116%. Meanwhile, water absorption, antioxygenation, antibacterial behavior and air permeability were increased by 39%, 97%, 27% and 52%.

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“…A novel technique that holds promising expectations for future healthcare in space is tissue nanotransfection technology, which reprograms in vivo tissues and cells (e.g., fibroblasts in skin) to induce neurons and endothelial cells [ 100 ]. Furthermore, healthcare in space can benefit from drug delivery through transdermal polymeric systems, as this passive system requires no invasive medical procedures, and is easily self-administered [ 101 ].…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Spaceflight Stressors and Skin Health

et al. 2022

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Traveling to space puts astronauts at risk of developing serious health problems. Of particular interest is the skin, which is vitally important in protecting the body from harmful environmental factors. Although data obtained from long-duration spaceflight studies are inconsistent, there have been indications of increased skin sensitivity and signs of dermal atrophy in astronauts. To better understand the effects of spaceflight stressors including microgravity, ionizing radiation and psychological stress on the skin, researchers have turned to in vitro and in vivo simulation models mimicking certain aspects of the spaceflight environment. In this review, we provide an overview of these simulation models and highlight studies that have improved our understanding on the effect of simulation spaceflight stressors on skin function. Data show that all aforementioned spaceflight stressors can affect skin health. Nevertheless, there remains a knowledge gap regarding how different spaceflight stressors in combination may interact and affect skin health. In future, efforts should be made to better simulate the spaceflight environment and reduce uncertainties related to long-duration spaceflight health effects.

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Recent advances in polymeric transdermal drug delivery systems

Cited by 180 publications

References 146 publications

Molecularly Imprinted Polymers as State-of-the-Art Drug Carriers in Hydrogel Transdermal Drug Delivery Applications

Molecularly Imprinted Polymers as State-of-the-Art Drug Carriers in Hydrogel Transdermal Drug Delivery Applications

Dendrobium officinale Enzyme Changing the Structure and Behaviors of Chitosan/γ-poly(glutamic acid) Hydrogel for Potential Skin Care

Spaceflight Stressors and Skin Health

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