Recent Advances in Lipid-Based Vesicles and Particulate Carriers for Topical and Transdermal Application

Jain, Shashank; Patel, Niketkumar; Shah, Mansi; Khatri, Pinak; Vora, Namrata

doi:10.1016/j.xphs.2016.10.001

Cited by 223 publications

(156 citation statements)

References 228 publications

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“…Control of solute diffusion coefficient may be achieved by controlling the degree of cross-linking, degree of branching degree of crystallinity, size of crystallites of the macromolecular carrier, and by adding adjuvants, which may slow down diffusional process either by hindering the diffusion or due to thermodynamic changes (Jain et al 2017). …”

Section: Developmental Strategies and Formulation Development:-mentioning

confidence: 99%

“…These drugs are mainly those which has low solubility and high first pass metabolism ( . Another approach could be to change the route for the drug delivery which is through skin (Jain et al 2017). Transdermal drug delivery has many advantages to offer over oral routes such as avoidance of first pass metabolism, avoidance of harsh gastric environment, patient compliance, easy to withdraw in case of unexpected situation, controlled and programmable delivery, easy to use and patient compliance for unconscious, vomiting and pediatric patients as well (Morales et al 2017;Vora, Lin, and Madan 2013).…”

Section: Introduction:-mentioning

confidence: 99%

See 1 more Smart Citation

Transdermal Drug Delivery Systems: A Mini Review.

Patel¹,

Patel²,

Prajapati³

et al. 2018

IJAR

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Section: Developmental Strategies and Formulation Development:-mentioning

confidence: 99%

Section: Introduction:-mentioning

confidence: 99%

Transdermal Drug Delivery Systems: A Mini Review.

Patel¹,

Patel²,

Prajapati³

et al. 2018

IJAR

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“…Dissolution enhancement of Rosuvastatin Calcium by liquisolid compact technique and development of microemulsion of Rosuvastatin Calcium are reported in the literature [5,6]. In recent past, colloidal lipid based nano delivery system has been successfully utilized to deliver poorly bioavailable drug via oral route [7][8][9][10][11]. However, based on the literature review, only limited studies had been performed with Rst [12,13].…”

Section: Introductionmentioning

confidence: 99%

Rosuvastatin calcium-loaded Solid Lipid Nanoparticles (SLN) using design of experiment approach for oral delivery

Beniwal¹,

Choudhary²

2017

IJCLS

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This investigation utilizes quality-by-design approach to develop the Rosuvastatin Calcium (Rst)-loaded solid lipid nanoparticles (SLN). Effect of formulation variables such as amount of lipid (200-500 mg stearic acid) and surfactant concentration (0.5-2.0% PVA) were studied. Design of Experiment (DoE) was used to quantify the extent of impact of lipid amount and surfactant concentration on the physicochemical properties of the SLN and to identify optimized SLN formulation. It was observed that interplay of formulation variables had significant effect on particle size (198.25 to 622.36 nm), %EE (28.82 to 35.87%) and In vitro release (44.87 to 64.29%). Based on the results, point optimization was carried out to obtain the SLN with minimum particle size (202.5 ± 9.29 nm), maximum %EE (34.78 ± 0.37 %) and sustained In vitro release (57.3 ± 2.6 % at 36 hours) within the design space. In vitro drug release data fitted well in Korsmeyer-peppas model indicating the fickian diffusion mechanism. Ex vivo studies indicated sustained permeation of the Ropt compared to the control. Furthermore, stability studies indicated Ropt formulation exhibited no significant physical or chemical change under accelerated conditions.

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“…They can be used as carriers to enhance drug permeation into the stratum corneum (SC), leading to the formation of drug reservoirs in the skin and prolonging the duration of action in lesions via sustained drug release. [1][2][3] For the topical application of drugs, liposomes can increase distribution in local tissues and reduce the systemic absorption of drugs, thereby minimizing side effects and improving local bioavailability. [4][5][6] Psoralen (Fig.…”

mentioning

confidence: 99%

“…A microdialysis probe was implanted in about 0.22 mm-deep skin tissue and the active dialysis window was placed immediately below the site of topical drug administration. The donor cell was stuck to the skin, just above the probe, and 1 mL of the test formulation was applied to the skin with a contact area of approximately 0.8 cm 2 . Dialysate samples were detected by HPLC following previously described methods, and the drug concentration in deep skin tissue was adjusted by in vivo recovery.…”

mentioning

confidence: 99%

<i>In Vivo</i> Microdialysis for Dynamic Monitoring of the Effectiveness of Nano-liposomes as Vehicles for Topical Psoralen Application

Zhang

et al. 2017

Biological & Pharmaceutical Bulletin

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In this study, the skin permeation of liposomes containing psoralen was investigated by in vivo skin microdialysis. Psoralen-loaded nano-sized liposomes were prepared with a mean size of 117.5 nm and a polydispersity index of 0.21, indicating the uniform dispersion of phosphatidylcholine vesicles in the liposomal solution. Based on in vivo microdialysis experiments, the drug concentration in local deep skin of rat increased rapidly and reached a peak concentration (C max ) of 319.35 23.72 µg/mL at 180 min, and decreased slowly thereafter. The local area under the concentration-time curve (AUC) 0-t was 3.81-fold higher than the compared aqueous suspension. The in vivo systemic pharmacokinetics were in agreement with the microdialysis results, in view of the C max and AUC 0-t from liposomal group were both significantly higher (p<0.05) than the compared group. Liposome-associated transdermal psoralen delivery was significantly more effective than delivery via an aqueous suspension. The enhanced skin permeability may be associated with improved skin hydration, lipid exchange and fusion with the stratum corneum (SC), and changes in SC structure, promoting drug permeation into deep skin. After 10 h of treatment with the perfusate, the microstructure of the microdialysis probe exhibited no obvious differences with control probes. The skin surface and the tissue around the probe showed no swelling or inflammation. These findings indicated that liposomes effectively enhanced the skin deposition of psoralen and showed good biocompatibility with skin tissues; additionally, ethanol at a low concentration in ringer's solution is an alternative perfusate for in vivo skin microdialysis studies.

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Recent Advances in Lipid-Based Vesicles and Particulate Carriers for Topical and Transdermal Application

Cited by 223 publications

References 228 publications

Transdermal Drug Delivery Systems: A Mini Review.

Transdermal Drug Delivery Systems: A Mini Review.

Rosuvastatin calcium-loaded Solid Lipid Nanoparticles (SLN) using design of experiment approach for oral delivery

<i>In Vivo</i> Microdialysis for Dynamic Monitoring of the Effectiveness of Nano-liposomes as Vehicles for Topical Psoralen Application

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