Recent Advances in Functional Polymer Decorated Two‐Dimensional Transition‐Metal Dichalcogenides Nanomaterials for Chemo‐Photothermal Therapy

Abstract

Novel nanomaterials and advanced nanotechnologies continue to promote the fast development of new approaches for efficient tumor therapy. As an alternative choice to various traditional therapies, non-invasive photothermal therapy (PTT) has attracted significant attention mainly due to its low cost, highly localizing, specific tumor treatment and minimal side effects on healthy tissues. PTT induced by photo-absorbing agents which can absorb and convert the external NIR laser into heat to ablate tumors. Plenty of studies have shown the significant potential of PTT to treat tumors in future practical applications. However, PTT alone usually could not eradicate tumors considering the intensity of laser gradual attenuates in biological tissues and the heat generated tends to distribute inhomogeneous within tumors tissues. Combination of chemotherapy with photothermal therapy into one system for tumor therapy is an effective strategy to further improve the therapy efficiency. In this Minireview, we focus on the recent advances in constructing PTT therapeutic and multi-model combination therapeutic via integrating nanomaterials and functional polymers.

Recent advances in metallopolymer-based drug delivery systems

“…222 The reversible ferrocene/ferricinium (Fc/Fcium) redox couple has attracted considerable attention for the dynamic redox switching of DDSs created using Fc-containing polymers. 116 The "on-demand" release of loaded drugs was achieved in response to external redox stimuli. Breathing poly-2-(methacryloyloxy)ethylferrocenecarboxylate (PFcMA)-containing NCs were used for redox-controlled release ( Fig.…”

“…The construction of MPs is a new strategy for signicantly increase the effectiveness of biomedical materials, in particular, to address current issues of traditional methods of treatment and prophylactics. 48,[114][115][116][117][118][119][120][121][122][123][124][125][126][127][128][129][130][131][132] Research on MPs in the biomedical eld is impressive. Materials scientists are designing MPs as innovative solutions to improve the effectiveness of DDSs.…”

Near infrared-light responsive WS2microengines with high-performance electro- and photo-catalytic activities

“…3,4 Such a unique combination of physical, optical, chemical and electronic properties has been exploited in a myriad of applications such as electronic devices, 5 photocatalysis, [6][7][8] energy storage, 3,9-11 sensing 12-14 and biomedicine. [15][16][17] The fabrication of continuous WS 2 lms has been achieved by top-down exfoliation of the bulk material 18 or bottom-up approaches such as chemical vapor deposition, hydrothermal synthesis or sulfurization. [18][19][20] Electrochemical synthesis is a simple approach that can be performed under ambient conditions using aqueous precursors, yielding excellent nanostructures for (photocatalytic) processes.…”

Multifunctional Polypyrrole‐Coated Mesoporous TiO2 Nanocomposites for Photothermal, Sonodynamic, and Chemotherapeutic Treatments and Dual‐Modal Ultrasound/Photoacoustic Imaging of Tumors

“…Photothermal therapy (PTT), as another noninvasive tumor treatment with potential effectiveness, has gained high attention in recent years . PTT employs photoabsorbing nanomaterials to convert near‐infrared (NIR, 700–1100 nm) laser into heat for thermal ablation of tumor cells . Hence, designing a suitable photothermal agent with good photothermal effect and relatively high biosafety is important for the application of PTT.…”