Recent Advances in D-Lactic Acid Production from Renewable Resources

Alexandri, Maria; Schneider, Roland; Mehlmann, Kerstin; Venus, Joachim

doi:10.17113/ftb.57.03.19.6023

Cited by 56 publications

(24 citation statements)

References 65 publications

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“…Lactic acid is a bio-based chemical used in the food, chemical, and healthcare industries. Lactic acid is used to make polylactic acid (PLA), a biodegradable polymer that is widely used in packaging material, mulch film, garbage bags, and medical materials [ 1 , 2 ]. PLA is typically produced from racemic mixtures, although it can also be produced from pure enantiomers to make homopolymers of poly-L-lactic acid (PLLA) or poly-D-lactic acid (PDLA).…”

Section: Introductionmentioning

confidence: 99%

D-Lactic Acid Production from Sugarcane Bagasse by Genetically Engineered Saccharomyces cerevisiae

Sornlek

Sae-Tang

Watcharawipas

et al. 2022

JoF

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Lactic acid (LA) is a promising bio-based chemical that has broad applications in food, nutraceutical, and bioplastic industries. However, production of the D-form of LA (D-LA) from fermentative organisms is lacking. In this study, Saccharomyces cerevisiae harboring the D-lactate dehydrogenase (DLDH) gene from Leuconostoc mesenteroides was constructed (CEN.PK2_DLDH). To increase D-LA production, the CRISPR/Cas12a system was used for the deletion of gpd1, gpd2, and adh1 to minimize glycerol and ethanol production. Although an improved D-LA titer was observed for both CEN.PK2_DLDHΔgpd and CEN.PK2_DLDHΔgpdΔadh1, growth impairment was observed. To enhance the D-LA productivity, CEN.PK2_DLDHΔgpd was crossed with the weak acid-tolerant S. cerevisiae BCC39850. The isolated hybrid2 showed a maximum D-LA concentration of 23.41 ± 1.65 g/L, equivalent to the improvement in productivity and yield by 2.2 and 1.5 folds, respectively. The simultaneous saccharification and fermentation using alkaline pretreated sugarcane bagasse by the hybrid2 led to an improved D-LA conversion yield on both the washed solid and whole slurry (0.33 and 0.24 g/g glucan). Our findings show the exploitation of natural yeast diversity and the potential strategy of gene editing combined with conventional breeding on improving the performance of S. cerevisiae for the production of industrially potent products.

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Section: Introductionmentioning

confidence: 99%

D-Lactic Acid Production from Sugarcane Bagasse by Genetically Engineered Saccharomyces cerevisiae

Sornlek

Sae-Tang

Watcharawipas

et al. 2022

JoF

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“…Lactic acid (LA) is the simplest hydroxyl acid with an asymmetric carbon atom and two optically active configurations, namely the L and D isomers (Figure 2). LA is a wellestablished bio-based chemical and its global annual production amounts to approximately 270 kilo tons per year [39]. It finds applications in several sectors ranging from the food industry to cosmetics and pharmaceuticals, and it is also employed for the synthesis of PLA, which is by far the most commercially developed bio-based plastic that is mainly applied in packaging and in pharmaceutical industries.…”

Section: Lactic Acidmentioning

confidence: 99%

Monomers, Materials and Energy from Coffee By-Products: A Review

et al. 2021

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In recent years, the circular economy and sustainability have gained attention in the food industry aimed at recycling food industrial waste and residues. For example, several plant-based materials are nowadays used in packaging and biofuel production. Among them, by-products and waste from coffee processing constitute a largely available, low cost, good quality resource. Coffee production includes many steps, in which by-products are generated including coffee pulp, coffee husks, silver skin and spent coffee. This review aims to analyze the reasons why coffee waste can be considered as a valuable source in recycling strategies for the sustainable production of bio-based chemicals, materials and fuels. It addresses the most recent advances in monomer, polymer and plastic filler productions and applications based on the development of viable biorefinery technologies. The exploration of strategies to unlock the potential of this biomass for fuel productions is also revised. Coffee by-products valorization is a clear example of waste biorefinery. Future applications in areas such as biomedicine, food packaging and material technology should be taken into consideration. However, further efforts in techno-economic analysis and the assessment of the feasibility of valorization processes on an industrial scale are needed.

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“…The most recent reviews about LA production and achievable products are outlined in Table 1. The topic of lactic acid research has been reviewed on substrate sources covering biowaste (Ahmad et al, 2020;Ajala et al, 2020;Alexandri et al, 2019;López-Gómez et al, 2020b;Nduko and Taguchi, 2021). Lactic acid production has been covered using catalysts (Razali and Abdullah, 2017) and fermentation with LAB (Martinez et al, 2013;Peng et al, 2020;Rawoof et al, 2021).…”

Section: Introductionmentioning

confidence: 99%