Recent Advances in Carbon Nanotubes for Nervous Tissue Regeneration

Redondo-Gómez, Carlos; Leandro-Mora, Rocío; Blanch-Bermúdez, Daniela; Espinoza-Araya, Christopher; Hidalgo-Barrantes, David; Vega-Baudrit, José Roberto

doi:10.1155/2020/6861205

Cited by 37 publications

(17 citation statements)

References 103 publications

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“…Although they demonstrate good conductivity and polymer composites have been designed with appropriate mechanical properties, the regulatory pathway for new materials and in particular carbon nanomaterials has hindered their clinical translation. 311 , 312 Conductive polymers (CPs) 313 have also emerged as a potential solution due to their high charge injection capacity and ionic conductance. 304 , 313 − 316 CPs are characterized by alternating single and double bonds along the backbone, termed π-conjugation, which cause a delocalization of electrons.…”

Section: Considerations For Electrical Stimulationmentioning

confidence: 99%

“…Carbon based nanomaterials such as nanotubes (CNT) and graphene have been explored to confer electroactivity to scaffolds. Although they demonstrate good conductivity and polymer composites have been designed with appropriate mechanical properties, the regulatory pathway for new materials and in particular carbon nanomaterials has hindered their clinical translation. , Conductive polymers (CPs) have also emerged as a potential solution due to their high charge injection capacity and ionic conductance. ,− CPs are characterized by alternating single and double bonds along the backbone, termed π-conjugation, which cause a delocalization of electrons. Some of the most commonly used CPs for in vivo studies are poly(3,4-ethylenedioxythiophene) (PEDOT), polypyrrole (PPy), and polyaniline (PANI) .…”

Section: Considerations For Electrical Stimulationmentioning

confidence: 99%

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Self-Assembling Hydrogel Structures for Neural Tissue Repair

Peressotti

Koehl

Goding

et al. 2021

ACS Biomater. Sci. Eng.

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Hydrogel materials have been employed as biological scaffolds for tissue regeneration across a wide range of applications. Their versatility and biomimetic properties make them an optimal choice for treating the complex and delicate milieu of neural tissue damage. Aside from finely tailored hydrogel properties, which aim to mimic healthy physiological tissue, a minimally invasive delivery method is essential to prevent off-target and surgery-related complications. The specific class of injectable hydrogels termed self-assembling peptides (SAPs), provide an ideal combination of in situ polymerization combined with versatility for biofunctionlization, tunable physicochemical properties, and high cytocompatibility. This review identifies design criteria for neural scaffolds based upon key cellular interactions with the neural extracellular matrix (ECM), with emphasis on aspects that are reproducible in a biomaterial environment. Examples of the most recent SAPs and modification methods are presented, with a focus on biological, mechanical, and topographical cues. Furthermore, SAP electrical properties and methods to provide appropriate electrical and electrochemical cues are widely discussed, in light of the endogenous electrical activity of neural tissue as well as the clinical effectiveness of stimulation treatments. Recent applications of SAP materials in neural repair and electrical stimulation therapies are highlighted, identifying research gaps in the field of hydrogels for neural regeneration.

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Section: Considerations For Electrical Stimulationmentioning

confidence: 99%

Section: Considerations For Electrical Stimulationmentioning

confidence: 99%

Self-Assembling Hydrogel Structures for Neural Tissue Repair

Peressotti

Koehl

Goding

et al. 2021

ACS Biomater. Sci. Eng.

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“…Carbon-based nanofillers, including carbon nanotubes (CNTs) and graphene, draw attention to neural tissue engineering applications for their attractive electrical and mechanical properties. These nanofillers possess many unrivaled benefits, including mechanical strength, chemical stability, large surface-to-volume ratio, and high electrical conductivity [49]. In the neural tissue engineering field, it holds in high regard and a continuous effort have been made to combine them with available materials for the application of scaffold reinforcements, tissue regeneration, drug delivery, and biosensor.…”

Section: Conductive Carbon Nanofiller-based Scaffoldmentioning

confidence: 99%

Electrical Stimulation-Mediated Differentiation of Neural Cells on Conductive Carbon Nanofiller-Based Scaffold

Kaushik

Khatua

Ghosh

et al. 2022

Biomedical Materials & Devices

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An important strategy in neural tissue engineering involves imparting electrical properties to the regenerative template to encourage cell proliferation and differentiation. Several clinical studies have confirmed that direct or indirect electrical stimulation therapy greatly impacts the treatment of peripheral and central nerve injury. Nerve regeneration can be accelerated by the application of electrical stimulations of different methods and with varying parameters. For a long period, electrical stimulation along with conventional conductive polymers have played an important role in nerve tissue regeneration, due to their conductivity. However, the low biocompatibility of these materials has brought attention toward the need for the alternative of the conductive polymers. Carbon nanofillers (graphene, nanotubes, and their derivatives) have been showing promising results in bioimaging, biosensing, and composites, simultaneously, proving themselves as a prospective biomaterial in neural tissue repair and regeneration due to their excellent electrical and mechanical properties, alongside, biocompatibility. Therefore, carbon nanofiller-based scaffolds synchronized with electrical stimulation may lead to a breakthrough in the treatment of nerve injury. This review article focuses on the influence of the electrical properties of carbon-based material on nerve tissue engineering. In this article, we explicitly focus on the different methods to deliver electrical stimulation and the pathways involved in the differentiation of neuronal cells. Emphasis is given to the analysis of the suitable fabrication strategies of carbon-based neural scaffold and the way its interfaces interact with neurons for promoting neuronal differentiation. Furthermore, this review summarizes the ongoing advancements to augment the conductivity and biological activities (cell adhesion, proliferation, neural differentiation, neurite outgrowth), as well as to reduce the potential toxicity in conductive carbon nanofiller-based scaffolds.

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“…CNTs are electrically stable materials, can interact with electroactive tissue such as neural, cardiac and bone tissues [ [159] , [160] , [161] , [162] ]. This property is extensively investigated in cardiac tissue engineering applications.…”

Section: Application Of Cnms In Cardiovascular Tissue Engineeringmentioning

confidence: 99%

Carbon nanomaterials for cardiovascular theranostics: Promises and challenges

Alagarsamy

Mathan

Yan

et al. 2021

Bioactive Materials

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Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Heart attack and stroke cause irreversible tissue damage. The currently available treatment options are limited to “damage-control” rather than tissue repair. The recent advances in nanomaterials have offered novel approaches to restore tissue function after injury. In particular, carbon nanomaterials (CNMs) have shown significant promise to bridge the gap in clinical translation of biomaterial based therapies. This family of carbon allotropes (including graphenes, carbon nanotubes and fullerenes) have unique physiochemical properties, including exceptional mechanical strength, electrical conductivity, chemical behaviour, thermal stability and optical properties. These intrinsic properties make CNMs ideal materials for use in cardiovascular theranostics. This review is focused on recent efforts in the diagnosis and treatment of heart diseases using graphenes and carbon nanotubes. The first section introduces currently available derivatives of graphenes and carbon nanotubes and discusses some of the key characteristics of these materials. The second section covers their application in drug delivery, biosensors, tissue engineering and immunomodulation with a focus on cardiovascular applications. The final section discusses current shortcomings and limitations of CNMs in cardiovascular applications and reviews ongoing efforts to address these concerns and to bring CNMs from bench to bedside.

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Recent Advances in Carbon Nanotubes for Nervous Tissue Regeneration

Cited by 37 publications

References 103 publications

Self-Assembling Hydrogel Structures for Neural Tissue Repair

Self-Assembling Hydrogel Structures for Neural Tissue Repair

Electrical Stimulation-Mediated Differentiation of Neural Cells on Conductive Carbon Nanofiller-Based Scaffold

Carbon nanomaterials for cardiovascular theranostics: Promises and challenges

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