Recent Advances in Biomedical Photonic Sensors: A Focus on Optical-Fibre-Based Sensing

Ochoa, Mario; Algorri, José Francisco; Roldán-Varona, Pablo; Rodŕıguez-Cobo, Luis; López‐Higuera, José Miguel

doi:10.3390/s21196469

Cited by 32 publications

(17 citation statements)

References 189 publications

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“…Optical and Photonic Sensing: The optical and photonic sensing platforms have been widely employed in the development of biomedical and analytical sensing devices because of their high accuracy, efficiency, and versatility. [135] The modification of physicochemical characteristics such as electronic bandgap, dielectric behavior, electrical conductivity, and structural design, can improve the light response and the detection performance in biodegradable optical sensors and e-skins. In this regard, the application of natural and synthetic biodegradable materials and waveguides such as cellulose, [136,137] chitin, [138] silk, [139] PLA, [140] and PLLA [141] have been reported.…”

Section: Other Mechanismsmentioning

confidence: 99%

Advances in Biodegradable Electronic Skin: Material Progress and Recent Applications in Sensing, Robotics, and Human–Machine Interfaces

et al. 2022

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The signals generated by these stimuli are transferred to the central neural network and brain to provide an appropriate response. In addition, biological skin possesses unique characteristics, such as stretchability, self-healing ability, and mechanical toughness. [1][2][3] It also provides an effective barrier against ambient elements such as chemicals, gases, radiation, and external biological agents.Electronic skin (e-skin) is an artificial smart skin composed of various electronic sensors distributed on a single uniform surface or stacked on multiple surfaces. It mimics some of the biological skin senses and provides a promising sensing platform for key application areas such as wearable sensors, robotics, and prosthetics (Figure 1). [1,[4][5][6][7][8][9][10][11] However, serious concerns have arisen regarding the production of electronic waste (e-waste), the influence of e-skin on human health, the safety of wearable electronic devices, costs, and environmental limitations. These concerns have encouraged researchers to develop biocompatible, renewable, sustainable, and biodegradable flexible wearable detection devices and biosensing platforms. [12][13][14][15][16] Biological skin regularly regenerates the old superficial layer of the epidermis with new skin cells during the healing process. Inspired by this natural degradation cycle, artificial biodegradable skin-based electronics should be designed for programmable degradation, in contrast to conventional electronic materials. To achieve this goal, the development of biocompatible, environmentally friendly electronic systems that can be used for the fabrication of biodegradable and sustainable e-skins is important.Various low-cost, nontoxic, renewable, and natural substances and polymer-based materials that can be applied to the development of sustainable, biodegradable e-skins and alleviate the environmental and health risks of e-waste materials are available. [17][18][19][20][21][22] E-waste disrupts the biological activity of microbial enzymes and their metabolisms, which decreases the resistance and the diversity of soil-based microbial communities. [23] In addition, in the human body, the accumulation of metals and metalloids used in the fabrication of conventional electronics can cause a range of biophysical malfunctions and diseases, such as liver damage by Cu, behavioral disorders by Pb, and lung cancer and kidney damage by Cd. [24][25][26][27] The rapid growth of the electronics industry and proliferation of electronic materials and telecommunications technologies has led to the release of a massive amount of untreated electronic waste (e-waste) into the environment. Consequently, catastrophic environmental damage at the microbiome level and serious human health diseases threaten the natural fate of the planet. Currently, the demand for wearable electronics for applications in personalized medicine, electronic skins (e-skins), and health monitoring is substantial and growing. Therefore, "green" characteristics such as biodegradability, self-healin...

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Section: Other Mechanismsmentioning

confidence: 99%

Advances in Biodegradable Electronic Skin: Material Progress and Recent Applications in Sensing, Robotics, and Human–Machine Interfaces

et al. 2022

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“…When coated with adequate fluorescent polymers, they also allow for the detection of molecules that are otherwise imperceptible with optical spectroscopy [ 7 , 8 ]. Moreover, the availability of fiber bundles and microstructured fibers (e.g., photonic crystal fibers) has offered novel means for the development of devices for fluorescence imaging, as well as sensor arrays [ 7 , 8 , 9 , 10 , 11 ]. The combination of novel fiber optic structures and fluorescent polymer composites has thus increased the potential of fiber optic sensors in biochemical and biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Luminescent Polymer Composites for Optical Fiber Sensors

2023

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Optical fiber sensors incorporating luminescent materials are useful for detecting physical parameters and biochemical species. Fluorescent materials integrated on the tips of optical fibers, for example, provide a means to perform fluorescence thermometry while monitoring the intensity or the spectral variations of the fluorescence signal. Similarly, certain molecules can be tracked by monitoring their characteristic emission in the UV wavelength range. A key element for these sensing approaches is the luminescent composite, which may be obtained upon allocating luminescent nanomaterials in glass or polymer hosts. In this work, we explore the fluorescence features of two composites incorporating lanthanide-doped fluorescent powders using polydimethylsiloxane (PDMS) as a host. The composites are obtained by a simple mixing procedure and can be subsequently deposited onto the end faces of optical fibers via dip coating or molding. Whereas one of the composites has shown to be useful for the fabrication of fiber optic temperature sensors, the other shows promising result for detection of UV radiation. The performance of both composites is first evaluated for the fabrication of membranes by examining features such as fluorescent stability. We further explore the influence of parameters such as particle concentration and density on the fluorescence features of the polymer blends. Finally, we demonstrate the incorporation of these PDMS fluorescent composites onto optical fibers and evaluate their sensing capabilities.

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“…Therefore, highly sensitive RI sensors based on photonic structures lead us to the cost effective, rapid, and precise detection of substances, making them suitable for environmental monitoring, food quality control, and especially medical diagnosis such as detecting bacterial infections, cancer, disorders, various physical and biological parameters to examine and treat health conditions, etc. [ 4 , 5 , 6 , 7 ]. In recent times liquid biopsies are becoming a popular medical diagnosis technique to detect and monitor cancerous tumors through the detection of different biomarkers such as circulating tumor cells (CTCs), circulating tumor nucleic acids ctNAs (ctDNA, microRNAs), as well as extracellular vesicles (EVs) [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Refractive Index Sensor Based on Polymer Bragg Grating: A Case Study on Extracellular Vesicles Detection

Saha

Brunetti

Kumar³

et al. 2022

Biosensors

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The measurement of small changes in the refractive index (RI) leads to a comprehensive analysis of different biochemical substances, paving the way to non-invasive and cost-effective medical diagnosis. In recent times, the liquid biopsy for cancer detection via extracellular vesicles (EV) in the bodily fluid is becoming very popular thanks to less invasiveness and stability. In this context, here we propose a highly sensitive RI sensor based on a compact high-index-coated polymer waveguide Bragg grating with a metal under cladding. Owing to the combined effect of a metal under cladding and a high-index coating, a significant enhancement in the RI sensitivity as well as the dynamic range has been observed. The proposed sensor has been analyzed by combining finite element method (FEM) and coupled-mode theory (CMT) approaches, demonstrating a sensitivity of 408–861 nm/RIU over a broad dynamic range of 1.32–1.44, and a strong evanescent field within a 150 nm proximity to the waveguide surface compliant with EV size. The aforementioned performance makes the proposed device suitable for performing real-time and on-chip diagnoses of cancer in the early stage.

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Recent Advances in Biomedical Photonic Sensors: A Focus on Optical-Fibre-Based Sensing

Cited by 32 publications

References 189 publications

Advances in Biodegradable Electronic Skin: Material Progress and Recent Applications in Sensing, Robotics, and Human–Machine Interfaces

Advances in Biodegradable Electronic Skin: Material Progress and Recent Applications in Sensing, Robotics, and Human–Machine Interfaces

Luminescent Polymer Composites for Optical Fiber Sensors

Highly Sensitive Refractive Index Sensor Based on Polymer Bragg Grating: A Case Study on Extracellular Vesicles Detection

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