Recent advances and prospects for lipid-based nanoparticles as drug carriers in the treatment of human retinal diseases

Zeng, Shaoxue; Chen, Yingying; Zhou, Fanfan; Zhang, Ting; Fan, Xiaohui; Chrzanowski, Wojciech; Gillies, Mark C; Zhu, Ling

doi:10.1016/j.addr.2023.114965

Cited by 9 publications

(4 citation statements)

References 182 publications

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“…The signification of and application of nanotechnologies to diagnose and treatment of this form of cancer has been substantially advanced in recent years, using LBNPs as well. For instance, it has been demonstrated that docetaxel-NE and NE lipophilic diffuse methane have improved antitumor action in cells of A-549 ( 171 ). Even more successful than normal cells was nebulized docetaxel NE (MRC-5 cells) against tumor cells (A-549 cells), creating a standard framework for coencapsulating gemcitabine (GEM) and PTX with a ligand that targets the glucose receptor ( 172 ).…”

Section: Applications Of Lbnps In Cancer Therapymentioning

confidence: 99%

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Waheed,

Ali,

Tabassum

et al. 2024

Front. Oncol.

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Cancer is a severe disease that results in death in all countries of the world. A nano-based drug delivery approach is the best alternative, directly targeting cancer tumor cells with improved drug cellular uptake. Different types of nanoparticle-based drug carriers are advanced for the treatment of cancer, and to increase the therapeutic effectiveness and safety of cancer therapy, many substances have been looked into as drug carriers. Lipid-based nanoparticles (LBNPs) have significantly attracted interest recently. These natural biomolecules that alternate to other polymers are frequently recycled in medicine due to their amphipathic properties. Lipid nanoparticles typically provide a variety of benefits, including biocompatibility and biodegradability. This review covers different classes of LBNPs, including their characterization and different synthesis technologies. This review discusses the most significant advancements in lipid nanoparticle technology and their use in medicine administration. Moreover, the review also emphasized the applications of lipid nanoparticles that are used in different cancer treatment types.

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Section: Applications Of Lbnps In Cancer Therapymentioning

confidence: 99%

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Waheed,

Ali,

Tabassum

et al. 2024

Front. Oncol.

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“…Liposome delivery systems are currently accepted as the most suitable delivery system for encapsulated anticancer drugs with respect to pharmacological stability and pharmacokinetics, and liposomes are biodegradable and have the potential to be loaded with high concentrations of anticancer drugs. 103 , 104 There are also R8 peptide‐PEGylated targeted liposomes for the treatment of gliomas, and data suggest good sustained release properties, improved stability, and increased liposomal ability to cross the blood–BBB. 105 , 106 Liposomes as a type of drug delivery system have significant advantages in antitumor drug delivery and are used in clinical practice to improve the efficacy of antitumor drugs and drug resistance.…”

Section: Overview Of Npsmentioning

confidence: 99%

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Liu,

Yang,

et al. 2024

CNS Neurosci Ther

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Gliomas are the most common primary tumors of the central nervous system, with glioblastoma multiforme (GBM) having the highest incidence, and their therapeutic efficacy depends primarily on the extent of surgical resection and the efficacy of postoperative chemotherapy. The role of the intracranial blood–brain barrier and the occurrence of the drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited the efficacy of chemotherapeutic agents in patients with GBM and made it difficult to achieve the expected clinical response. In recent years, the rapid development of nanotechnology has brought new hope for the treatment of tumors. Nanoparticles (NPs) have shown great potential in tumor therapy due to their unique properties such as light, heat, electromagnetic effects, and passive targeting. Furthermore, NPs can effectively load chemotherapeutic drugs, significantly reduce the side effects of chemotherapeutic drugs, and improve chemotherapeutic efficacy, showing great potential in the chemotherapy of glioma. In this article, we reviewed the mechanisms of glioma drug resistance, the physicochemical properties of NPs, and recent advances in NPs in glioma chemotherapy resistance. We aimed to provide new perspectives on the clinical treatment of glioma.

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“…31 These modified nanoparticles can then be integrated into a polymer matrix, which provides a significant number of ionizable groups on its surface. 32 This methodology not only retains the inherent magnetic properties of the nanoparticles but also simplifies and enhances the safety of the drug encapsulation process.…”

Section: ■ Introductionmentioning

confidence: 99%

“…To address this issue, it is viable to alter the collective magnetic nanoparticles by means of functionalization, a procedure that entails the use of synthetic or natural substances on their surface . These modified nanoparticles can then be integrated into a polymer matrix, which provides a significant number of ionizable groups on its surface . This methodology not only retains the inherent magnetic properties of the nanoparticles but also simplifies and enhances the safety of the drug encapsulation process.…”

Section: Introductionmentioning

confidence: 99%

Superparamagnetic Amine-Functionalized Maghemite Nanoparticles as a Thixotropy Promoter for Hydrogels and Magnetic Field-Driven Diffusion-Controlled Drug Release

Ganguly,

Das,

Srinivasan

et al. 2024

ACS Appl. Nano Mater.

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Superparamagnetic nanoparticle-arrested hydrogel matrices have immense significance in smart soft biomaterials. Herein, we report the synthesis of superparamagnetic nanoparticle-loaded magneto-responsive tough elastomeric hydrogels for dual-responsive drug delivery. In the first phase of work, we carried out roomtemperature synthesis of amine-functionalized superparamagnetic iron oxide nanoparticles (IONPs), and in the second phase of work, we demonstrated that IONPs could act as a toughening agent as well as a viscosity modifier for poly(acrylic acid-co-hydroxyethyl methacrylate) copolymer hydrogels. The hydrogel was tested by Fourier transformed infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), and continuous-wave-electron paramagnetic resonance (CW-EPR). Moreover, the IONPs affect its gelation time and elasticity significantly, which was also evaluated from its rheological behavior. The compressive mechanical strength (∼120 kPa), elasticity, recovery to original shape (zero permanent set), water uptake, and thixotropic behavior under dynamic stress of the hybrid hydrogels have supported its robustness in the swelled state. The drug release behavior of the hydrogel showed dual parameter dependency (IONPs and cross-linker) and dual responsiveness against both pH and static magnetic field. The delayed network rupturing, dualresponsive drug delivery nature, and noncytotoxic behavior against human live cells could promote this hybrid hydrogel as an ideal alternative for the remotely controlled drug delivery vehicle.

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Recent advances and prospects for lipid-based nanoparticles as drug carriers in the treatment of human retinal diseases

Cited by 9 publications

References 182 publications

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

Superparamagnetic Amine-Functionalized Maghemite Nanoparticles as a Thixotropy Promoter for Hydrogels and Magnetic Field-Driven Diffusion-Controlled Drug Release

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