Recent advances and future perspectives of sol–gel derived porous bioactive glasses: a review

Deshmukh, Kalim; Kovařík, Tomáš; Křenek, Tomáš; Docheva, Denitsa; Stich, Theresia; Pola, Josef

doi:10.1039/d0ra04287k

Cited by 140 publications

(76 citation statements)

References 483 publications

(852 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MBGs have several established medical applications such as bone regeneration [ 18 ], dentin remineralization [ 114 ], and much more. Studies are also underway to use mesoporous bioactive glasses for dental applications such as the prevention of prosthetic joint infections [ 115 ], as fillers in restorative materials, in direct contact with dentin and/or pulp tissues [ 21 ], dentinal sealing for the treatment of dentin hypersensitivity [ 116 ], coating for dental implants [ 115 ], and the treatment of periodontal diseases [ 117 ]. From the studies included, 74% of articles used MBG for bone regeneration.…”

Section: Resultsmentioning

confidence: 99%

Mesoporous Bioactive Glasses Cytocompatibility Assessment: A Review of In Vitro Studies

et al. 2021

View full text Add to dashboard Cite

Thanks to their high porosity and surface area, mesoporous bioactive glasses (MBGs) have gained significant interest in the field of medical applications, in particular, with regards to enhanced bioactive properties which facilitate bone regeneration. The aim of this article is to review the state of the art regarding the biocompatibility evaluation of MBGs and provide a discussion of the various approaches taken. The research was performed using PubMed database and covered articles published in the last five years. From a total of 91 articles, 63 were selected after analyzing them according to our inclusion and exclusion criteria. In vitro methodologies and techniques used for biocompatibility assessment were investigated. Among the biocompatibility assessment techniques, scanning electron microscopy (SEM) has been widely used to study cell morphology and adhesion. Viability and proliferation were assessed using different assays including cell counting and/or cell metabolic activity measurement. Finally, cell differentiation tests relied on the alkaline phosphatase assay; however, these were often complemented by specific bimolecular tests according to the exact application of the mesoporous bioactive glass. The standardization and validation of all tests performed for MBG cytocompatibility is a key aspect and crucial point and should be considered in order to avoid inconsistencies, bias between studies, and unnecessary consumption of time. Therefore, introducing standard tests would serve an important role in the future assessment and development of MBG materials.

show abstract

Section: Resultsmentioning

confidence: 99%

Mesoporous Bioactive Glasses Cytocompatibility Assessment: A Review of In Vitro Studies

et al. 2021

View full text Add to dashboard Cite

show abstract

“…BG will improve wound healing in various ways, as per our previous studies. BG can also assist chondrocyte development, and the chondrogenic molecular markers stimulate (Balestriere et al., 2020 ; Deshmukh et al., 2020 ; Dai et al., 2020 ). Recent research was performed to improve osteochondral regeneration through an injectable BG hydrogel that contains stem cells from the bone marrow (Manissorn et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Thermo-responsive injectable naringin-loaded hydrogel polymerised sodium alginate/bioglass delivery for articular cartilage

Yang

Wang

et al. 2021

Drug Delivery

View full text Add to dashboard Cite

In the human body, joint cartilage is of great importance. It has long been a big therapeutic problem to fix joint cartilage lesions as it appears due to different conditions. Recent stories have shown that the cartilage replacement process must delay the extracellular (ECM) cartilage deterioration and modulate the host's inflammation response. For the reconstruction of the articular cartilage, drug-loaded injectable hydrogels were developed. This hydrogel could retain the chondrocyte phenotype, but the host's inflammatory reaction could also be controlled. The bioglass (BG)/sodium alginate (SA) injectable hydrogels was combined with agarose (AG)/Naringin hydrogel in injectable thermal response for articular cartilage regeneration with a non-chargeable hydrogel that contains both Naringin and BG (Naringin–BG hydrogels). The Naringin–BG hydrogel has an adequate swelling ratio that encourages the fusion of tissue formed with host tissue and enables the gradual release of Naringin bioavailabilities enhanced in situ . The Naringin–BG hydrogel can upgrade the typical chondrocyte phenotype by upregulating aggrecan, SRY-box 9, and collagen type II alpha one chain. It may also stimulate the polarization of M2 macrophage, lower inflammations, and prevent ECM degradations through the decrease of the expressions of the indictable metalloproteinase-13 matrix, nitric oxide synthase, and metalloproteinase-1 matrix. The formed tissues were identical to normal tissues and firmly incorporated with the surrounding tissue after administering the Naringin–BG hydrogels into the rat model articular cartilage defects. Then the injectable Naringin–BG hydrogel increases the bioavailable content of Naringin and retains the chondrocyte phenotype.

show abstract

“…Despite the comprehensive reviews on hierarchically porous monoliths that have been published [ 1 , 4 , 6 , 7 ], to the best of our knowledge, there are no reviews in the literature on hierarchically porous microspheres achieved by the sol-gel/phase separation method. This review discusses the pioneering and development works, as well as the current state of the art and tendencies in the field of porosity control through sol-gel/phase separation occurring not only in bulk solutions, giving rise to porous monoliths, but also within tiny droplets of a microemulsion, which results in porous microspheres.…”

Section: Introductionmentioning

confidence: 99%

Macroporosity Control by Phase Separation in Sol-Gel Derived Monoliths and Microspheres

Marques

Vale

2021

Materials

View full text Add to dashboard Cite

Macroporous and hierarchically macro/mesoporous materials (mostly monoliths and microspheres) have attracted much attention for a variety of applications, such as supporting or enabling materials in chromatography, energy storage and conversion, catalysis, biomedical devices, drug delivery systems, and environmental remediation. A well-succeeded method to obtain these tailored porous materials relies on the sol-gel technique, combined with phase separation by spinodal decomposition, and involves as well emulsification as a soft template, in the case of the synthesis of porous microspheres. Significant advancements have been witnessed, in terms of synthesis methodologies optimized either for the use of alkoxides or metal–salts and material design, including the grafting or immobilization of a specific species (or nanoparticles) to enable the most recent trends in technological applications, such as photocatalysis. In this context, the evolution, in terms of material composition and synthesis strategies, is discussed in a concerted fashion in this review, with the goal of inspiring new improvements and breakthroughs in the framework of porous materials.

show abstract

Recent advances and future perspectives of sol–gel derived porous bioactive glasses: a review

Abstract: Sol–gel derived bioactive glasses have been extensively explored as a promising and highly porous scaffold materials for bone tissue regeneration applications owing to their exceptional osteoconductivity, osteostimulation and degradation rates.

Cited by 140 publications

References 483 publications

Mesoporous Bioactive Glasses Cytocompatibility Assessment: A Review of In Vitro Studies

Mesoporous Bioactive Glasses Cytocompatibility Assessment: A Review of In Vitro Studies

Thermo-responsive injectable naringin-loaded hydrogel polymerised sodium alginate/bioglass delivery for articular cartilage

Macroporosity Control by Phase Separation in Sol-Gel Derived Monoliths and Microspheres

Contact Info

Product

Resources

About