Recent advances and challenges in designing stimuli-responsive polymers

Liu, Fang; Urban, Marek W.

doi:10.1016/j.progpolymsci.2009.10.002

Cited by 906 publications

(332 citation statements)

References 132 publications

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“…One of the main groups of "smart" materials is based on polymers because they are cheaper and more easily tailored than metals or ceramics. These polymeric "smart" materials can respond to stimuli such as pH, temperature, ionic strength, electric or magnetic field, light and/or chemical and biological stimuli and consequently have a wide range of applications that include sensors, drug delivery, gene delivery and tissue engineering [1][2][3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Polymers for Biomedical Applications

2011

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Thermoresponsive polymers are a class of "smart" materials that have the ability to respond to a change in temperature; a property that makes them useful materials in a wide range of applications and consequently attracts much scientific interest. This review focuses mainly on the studies published over the last 10 years on the synthesis and use of thermoresponsive polymers for biomedical applications including drug delivery, tissue engineering and gene delivery. A summary of the main applications is given following the different studies on thermoresponsive polymers which are categorized based on their 3-dimensional structure; hydrogels, interpenetrating networks, micelles, crosslinked micelles, polymersomes, films and particles.

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Section: Introductionmentioning

confidence: 99%

Thermoresponsive Polymers for Biomedical Applications

2011

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“…This subtle adjustment in conformation may trigger a continuous change in polymer chains, ultimately resulting in a contracted state of the polymeric network. 36 On the basis of these presumptions, a possible mechanism ( Figure 4C) is proposed for explaining the chiral effect found previously. The added L-ribose preferred to combine with the dipeptide unit and destroyed the initial H-bond network constructed by the dipeptide units and PEI chains.…”

Section: Resultsmentioning

confidence: 77%

Surface Stiffness—a Parameter for Sensing the Chirality of Saccharides

Chen

et al. 2015

ACS Appl. Mater. Interfaces

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Surface stiffness is considered a key parameter for designing highperformance implantable materials and artificial extracellular matrices because of its substantial effects on cell behavior. How to transform biomolecule recognition events, particularly chiral recognition, into stiffness change on material surfaces is biologically essential but very challenging for chemists. Here, we report a chiralitytriggered stiffness transition on a smart polymer film, which consists of flexible polyethylenimine (PEI) main chains grafted with dipeptide units capable of discriminating chiral monosaccharides. The polymer film became substantially softer after interacting with L-ribose and became more rigid after interacting with D-ribose (the basic building block of DNA and RNA). This chiral effect provides a new method for determining the enantiomeric purity of an L/D-ribose mixture and facilitates the chiral separation of deoxyribose racemates as well as the separation of diverse mono-, di-, and oligosaccharides. These are three puzzle problems in carbohydrate chemistry. Furthermore, taking advantage of the significant differences in the surface stiffness, the proliferation of fibroblast cells on the polymeric surfaces can also be regulated by chiral biomolecules.

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“…The introduction of chirality into the backbone or side chains of smart responsive polymers helps to realize reversible chiral modulation of the helix conformations by external stimuli, for example, temperature, solvent, pH and light irradiation, which provide a satisfactory platform for mimicking chiral behaviors in nature. 20 Thermo-mediated transformation Temperature is one of most common stimuli in nature; it provides a convenient method to mediate the chiral conformation of polymers. In an early study by Tang et al, 21 the relationship between temperature and chiroptical activity of LCs was evaluated systematically.…”

Section: External Stimuli-mediated Transformation Of Chiral Conformatmentioning

confidence: 99%

The transformation of chiral signals into macroscopic properties of materials using chirality-responsive polymers

Qing

Sun

2012

NPG Asia Mater

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The ability to transform the chiral signals of molecules into the macroscopic properties of a material will offer significant advantages in the development of chiral functional devices and chirality-related applications. Chirality-responsive polymers provide an excellent platform to realize this objective, which often involves two basic strategies. The first strategy is to utilize various external stimuli to directly mediate the chiral conformations of a polymer, through which the energy input is transformed into a macroscopic change in the properties of a material. The second strategy is to utilize the enantioselective interaction between polymers and guest chiral molecules to trigger a stepwise conformational change in smart polymers, which then results in transformation of the macroscopic properties. This review summarizes recent progress in generating chirality-responsive polymers based on these strategies and discusses advances in their applications as chiral sensors, liquid crystals, optical and electrical devices, nanomachines and so on. We then introduce the emerging field of chiral bio-interface materials, in which chiral signals are transformed into changes in the macroscopic behavior of cells and biomacromolecules based on the stereospecific interactions between biological systems and artificial materials.

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Recent advances and challenges in designing stimuli-responsive polymers

Cited by 906 publications

References 132 publications

Thermoresponsive Polymers for Biomedical Applications

Thermoresponsive Polymers for Biomedical Applications

Surface Stiffness—a Parameter for Sensing the Chirality of Saccharides

The transformation of chiral signals into macroscopic properties of materials using chirality-responsive polymers

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