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Cited by 512 publications
(488 citation statements)
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References 42 publications
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“…Cell culture and differentiation H9 hESCs were purchased from WiCell Research, and cultured under standard hESC culture conditions as previously described (Liu et al, 2011). Differentiation of H9 hESC into hNSC was followed by the protocol described previously (Liu et al, 2012).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Cell culture and differentiation H9 hESCs were purchased from WiCell Research, and cultured under standard hESC culture conditions as previously described (Liu et al, 2011). Differentiation of H9 hESC into hNSC was followed by the protocol described previously (Liu et al, 2012).…”
Section: Methodsmentioning
confidence: 99%
“…Quantitative RT-PCR RT-qPCR was performed as described previously (Liu et al, 2011). The primer sequences were listed in Table S24.…”
Section: Microarray Analysismentioning
confidence: 99%
“…Similarly, such model can also be used as biomarker for aging study in model systems like human induced pluripotent stem cells and adult stem cells etc. and be applied to study mechanisms and establish a potential link between epigenetic modulation, genomic instability, and aging (Liu et al, 2011a(Liu et al, , 2011bHan and Brunet, 2012;Liu et al, 2012aLiu et al, , 2012bInukai and Slack, 2013). By exploring these relationships, we can build an aging-related epigenetic network so that a better understanding and theoretical studies of epigenetic factors essential for aging can be achieved.…”
Section: News and Viewsmentioning
confidence: 99%
“…Des données convergentes montrent que la reprogrammation vers la pluripotence permet une « remise à zéro » des marques épigéné-tiques [6] acquises au fur et à mesure du temps, sans profondément altérer les marques génétiques qui, elles, sont ancrées dans le génome de la cellule comme une marque irréversible (à moins que le génome ne soit modifié artificiellement). De plus, il a été démontré que, lorsqu'une cellule pluripotente induite est soumise à certains signaux environnementaux visant à mimer les étapes du développement, des processus de différenciation se mettent en place, et différents types cellulaires peuvent être obtenus, lesquels pourront réacquérir les marques de la maladie [7,8]. Ainsi, en reprogrammant vers un état « naïf » des cellules porteuses de mutation(s) génique(s), il devient désormais possible de reproduire le développement d'une maladie.…”
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