2014
DOI: 10.3389/fgene.2014.00211
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Abstract: A quantitative trait locus (QTL) in the nematode C. elegans, “lsq4,” was recently implicated by mapping longevity genes. QTLs for lifespan and three stress-resistance traits coincided within a span of <300 kbp, later narrowed to <200 kbp. A single gene in this interval is now shown to modulate all lsq4-associated traits. Full-genome analysis of transcript levels indicates that lsq4 contains a dimorphic gene governing the expression of many sperm-specific genes, suggesting an effect on spermatogenesis. Quantita… Show more

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Cited by 6 publications
(7 citation statements)
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References 48 publications
(72 reference statements)
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“…Paradoxically, overexpression of NDT80 lengthens the replicative lifespan of yeast, 56 despite that pGAL::NDT80 is toxic upon overexpression using glycerol-containing media. 19 REC8 overexpression also affects the replicative lifespan 57 and yet induces sectors (this work). Note that the red sectors observed using NDT80 and REC8 in the work are not caused by nondisjunction because no white sectors were observed.…”
Section: Discussionmentioning
confidence: 73%
“…Paradoxically, overexpression of NDT80 lengthens the replicative lifespan of yeast, 56 despite that pGAL::NDT80 is toxic upon overexpression using glycerol-containing media. 19 REC8 overexpression also affects the replicative lifespan 57 and yet induces sectors (this work). Note that the red sectors observed using NDT80 and REC8 in the work are not caused by nondisjunction because no white sectors were observed.…”
Section: Discussionmentioning
confidence: 73%
“…Genetic or environmental treatments that enhance life span also typically enhance resistance to environmental stress [ 1 3 , 5 , 6 ]. We first tested whether SC100 treatment also enhances stress resistance to partial starvation ( Table 16 ) using B4 flies.…”
Section: Resultsmentioning
confidence: 99%
“…Many studies indicate that aging is modulated by a large number of aging-related genes that often boost stress resistance [ 1 7 ]. This multipath nature of aging suggests that many genetic patterns must be altered simultaneously for a successful intervention into the aging process.…”
Section: Introductionmentioning
confidence: 99%
“…Most of the identified quantitative trait genes have paralogs, providing evidence that gene duplication events are important for shaping quantitative traits. Trends in Genetics The C. elegans community has identified numerous QTL (Table 1, and Table S1 in the supplemental information online) that underlie life history traits such as reproduction [5,[11][12][13][14][15][16][17][18][19][20][21], lifespan and aging [18,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36], body size and development [5,[12][13][14][15]17,18,21,27,32,[37][38][39][40][41][42][43][44][45]…”
Section: Discovering the Mechanisms Of Trait Variation One Gene At A Timementioning
confidence: 99%
“…Other strains have also been used to generate RIL panels to investigate natural variation that can be independent of the N2 and CB4856 variation [14,20,36,37,42,44,86,92] (Table 2). These panels were often made from strains that are divergent in a particular trait, and have led to the discovery of the role of nath-10 in vulval induction [37], plep-1 in plugging behavior [92], srx-43 and srx-44 in pheromone sensitivity [86], and set-24 in temperature-induced sterility [20].…”
Section: Trends Trends In In Genetics Geneticsmentioning
confidence: 99%