Reassessment of the neural control of body temperature: Importance of oscillating neural and motor components

A set-point model with oscillatory behavior predicts the time course of 8-OH-DPAT-induced hypothermia

“…When the model is fully pushed into its maximal effect, such as is the case for a relatively high dose of a full agonist, the system becomes overdamped, thereby losing its oscillatory behavior. Hence, the observed plateau phase is an intrinsic part of the regulatory mechanism related to the oscillatory behavior found in many regulatory systems (22,31).…”

A set-point model with oscillatory behavior predicts the time course of 8-OH-DPAT-induced hypothermia

“…When the model is fully pushed into its maximal effect, such as is the case for a relatively high dose of a full agonist, the system becomes overdamped, thereby losing its oscillatory behavior. Hence, the observed plateau phase is an intrinsic part of the regulatory mechanism related to the oscillatory behavior found in many regulatory systems (22,31).…”

Control of metabolic rate is a hidden variable in the allometric scaling of homeotherms

“…Although we offered saturation of responses as an example, we also acknowledge that a multiplicity of controllers, spatial heterogeneities in temperature distribution, non-linearities in the controllers themselves, and others (e.g. Gordon and Heath, 1983;Werner et al, 1989) would render the temporal patterns of the system more realistic, yet much more complex. The important point is that such temporal patterns would be more distant from the well-behaved δB=0 of the classical SMR.…”

Regulation and Modulation in Biology

“…Because of the inertia and nonlinear properties of the sensor, the modulating mechanism and/or the effector, the corrective feedback response is delayed, and thus produces a small sinusoidal oscillation in the regulated variable in the case of continuous disturbance. Reversing this argument, any physiological variable that exhibits small sinusoidal or quasi‐sinusoidal oscillations may be assumed to be regulated by a system analogous to the water tank described above 1,24,31,32 …”

A set-point model with oscillatory behavior predicts the time course of 8-OH-DPAT-induced hypothermia

“…When the model is fully pushed into its maximal effect, such as is the case for a relatively high dose of a full agonist, the system becomes overdamped, thereby losing its oscillatory behavior. Hence, the observed plateau phase is an intrinsic part of the regulatory mechanism related to the oscillatory behavior found in many regulatory systems (22,31).…”

Control of metabolic rate is a hidden variable in the allometric scaling of homeotherms

“…Although we offered saturation of responses as an example, we also acknowledge that a multiplicity of controllers, spatial heterogeneities in temperature distribution, non-linearities in the controllers themselves, and others (e.g. Gordon and Heath, 1983;Werner et al, 1989) would render the temporal patterns of the system more realistic, yet much more complex. The important point is that such temporal patterns would be more distant from the well-behaved δB=0 of the classical SMR.…”

Regulation and Modulation in Biology

“…Because of the inertia and nonlinear properties of the sensor, the modulating mechanism and/or the effector, the corrective feedback response is delayed, and thus produces a small sinusoidal oscillation in the regulated variable in the case of continuous disturbance. Reversing this argument, any physiological variable that exhibits small sinusoidal or quasi‐sinusoidal oscillations may be assumed to be regulated by a system analogous to the water tank described above 1,24,31,32 …”

A set-point model with oscillatory behavior predicts the time course of 8-OH-DPAT-induced hypothermia

“…When the model is fully pushed into its maximal effect, such as is the case for a relatively high dose of a full agonist, the system becomes overdamped, thereby losing its oscillatory behavior. Hence, the observed plateau phase is an intrinsic part of the regulatory mechanism related to the oscillatory behavior found in many regulatory systems (22,31).…”

Control of metabolic rate is a hidden variable in the allometric scaling of homeotherms

“…Although we offered saturation of responses as an example, we also acknowledge that a multiplicity of controllers, spatial heterogeneities in temperature distribution, non-linearities in the controllers themselves, and others (e.g. Gordon and Heath, 1983;Werner et al, 1989) would render the temporal patterns of the system more realistic, yet much more complex. The important point is that such temporal patterns would be more distant from the well-behaved δB=0 of the classical SMR.…”

Regulation and Modulation in Biology

“…Because of the inertia and nonlinear properties of the sensor, the modulating mechanism and/or the effector, the corrective feedback response is delayed, and thus produces a small sinusoidal oscillation in the regulated variable in the case of continuous disturbance. Reversing this argument, any physiological variable that exhibits small sinusoidal or quasi‐sinusoidal oscillations may be assumed to be regulated by a system analogous to the water tank described above 1,24,31,32 …”