Reasons for Early Ocular Hypertension after Uneventful Cataract Surgery

Fan, Fan; Luo, Yi; Lu, Yi; Liu, Xin

doi:10.5301/ejo.5000441

Cited by 8 publications

(9 citation statements)

References 30 publications

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“…; Fan et al. ). Patients with a history of glaucoma surgery, high myopia and diabetes mellitus carry a higher risk for early IOP elevation after surgery.…”

Section: Review Of the Literaturementioning

confidence: 98%

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Recovery after cataract surgery

Porela‐Tiihonen

Kokki

Kaarniranta

et al. 2016

Acta Ophthalmologica

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Cataract surgery is the most common ophthalmological surgical procedure, and it is predicted that the number of surgeries will increase significantly in the future. However, little is known about the recovery after surgery. The first aim of this study was to evaluate the prevalence, severity and duration of pain and other ocular discomfort symptoms experienced after cataract surgery. The other objectives were to identify the factors associated with lower postoperative patient satisfaction and to measure the effect of cataract surgery on patients’ health‐related quality of life (HRQoL) and visual function in everyday life. The study design was a prospective follow‐up study. The course of the recovery and the presence of ocular symptoms were evaluated by interviewing the patients via a questionnaire at 1 day, 1 week, 6 weeks and one year after surgery The visual functioning in everyday life was measured with Visual Functioning Index VF‐7 and Catquest‐9SF‐questionnaires and furthermore the HRQoL was measured with the 15D‐instrument before surgery and at 12 months after surgery. The patients returned the questionnaires by mail and were interviewed in the hospital on the day of the surgery. The same patients filled‐in all the questionnaires. The patient reports were used to collect the data on medical history. A total of 303 patients were approached at Kuopio University Hospital in 2010–2011 and of these 196 patients were eligible and willing to participate, with postoperative data being available from 186 (95%) patients. A systematic review article was included in the study procedure and it revealed the wide range in the reported incidence of postoperative ocular pain. Some of the identified randomized controlled studies reported no or only minor pain whereas in some studies significant pain or pain lasting for several weeks has been described in more than 50% of the study patients. In the present study setting, pain was reported by 34% during the first postoperative hours and by approximately 10% of patients during the first six weeks after surgery. During the early recovery in the hospital, only a minority of the patients reporting pain were provided with pain medication. The ocular discomfort symptoms such as itchiness, burning, foreign‐body sensation and tearing were common both before (54%) and after surgery (38–52%). These symptoms can also be described as painful symptoms and are often difficult to distinguish from ocular pain. The symptoms are also typical of ocular surface disease, and some patients may benefit from the postoperative administration of tear substitutes. The patients reporting postoperative ocular symptoms were less satisfied with the treatment outcome at 12 months after surgery (p = 0.001) compared to the patients who experienced no symptoms. Those patients reporting less disability in visual functioning before surgery were more satisfied than patients with more reported disability. The HRQoL improved significantly after cataract surgery (p = 0.002). However, when compared to an age‐...

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“…; Fan et al. ). Patients with a history of glaucoma surgery, high myopia and diabetes mellitus carry a higher risk for early IOP elevation after surgery.…”

Section: Review Of the Literaturementioning

confidence: 98%

“…; Fan et al. ). In some patients with preoperatively existing primary open‐angle glaucoma and ocular hypertension, there may be also a modest and long‐lasting decrease in IOP occurring after cataract surgery (Hayashi et al.…”

Section: Review Of the Literaturementioning

confidence: 98%

Recovery after cataract surgery

Porela‐Tiihonen

Kokki

Kaarniranta

et al. 2016

Acta Ophthalmologica

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“…Ocular inflammation was effectively induced in 12 dogs by 50 l (539.32 g) of canine lens protein solution (10.78 g/ml) injected intracamerally. Clinical signs of ocular inflammation were semiquantitatively scored on nine different occasions (1,2,3,4,5,6,12,24, and 48 hours after injection). The inflammatory response incited was immediately observed within 1 hour of the injection, with a markedly miotic pupil, and moderate amounts of protein (aqueous flare) and frank fibrin were detectable in the anterior chamber.…”

Section: Oral Efficacy Of Plga-ga 2 -Curmentioning

confidence: 99%

Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation

Ganugula¹,

Arora²,

Lepiz

et al. 2020

Sci. Adv.

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Novel approaches circumventing blood-ocular barriers in systemic drug delivery are lacking. We hypothesize receptor-mediated delivery of curcumin (CUR) across intestinal and ocular barriers leads to decreased inflammation in a model of lens-induced uveitis. CUR was encapsulated in double-headed polyester nanoparticles using gambogic acid (GA)–coupled polylactide-co-glycolide (PLGA). Orally administered PLGA-GA2-CUR led to notable aqueous humor CUR levels and was dosed (10 mg/kg twice daily) to adult male beagles (n = 8 eyes) with induced ocular inflammation. Eyes were evaluated using a semiquantitative preclinical ocular toxicology scoring (SPOTS) and compared to commercial anti-inflammatory treatment (oral carprofen 2.2 mg/kg twice daily) (n = 8) and untreated controls (n = 8). PLGA-GA2-CUR offered improved protection compared with untreated controls and similar protection compared with carprofen, with reduced aqueous flare, miosis, and chemosis in the acute phase (<4 hours). This study highlights the potential of PLGA-GA2 nanoparticles for systemic drug delivery across ocular barriers.

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“…Similar to most other surgical procedures, incisional ophthalmic procedures carry a small risk of infection [3, 4] and a more common physiologic reaction of inflammation in the immediate post-operative period [5, 6]. Post-surgical inflammation as well as corticosteroid treatment may induce intraocular pressure (IOP) increase in many patients [2, 7–9]. Increase in IOP may require additional topical treatment with ocular hypotensives, adding to the overall burden of treatment and decreasing patient adherence.…”

Section: Introductionmentioning

confidence: 99%

“…They are well tolerated with fewer side effects than other broad-spectrum immune suppressants [44]. Often an ocular hypotensive is also added to the post-operative treatment regimen to reduce IOP increase secondary to inflammation and/or corticosteroid use [2, 7–9]. Thus, a simple to administer, minimally-invasive ocular delivery system would be advantageous to the complex current standard of care and would improve patient compliance.…”

Section: Introductionmentioning

confidence: 99%

Injectable drug depot engineered to release multiple ophthalmic therapeutic agents with precise time profiles for postoperative treatment following ocular surgery

et al. 2018

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After ocular surgery, patients routinely receive multiple medications including antibiotics, steroids and ocular hypotensives to ensure optimal surgical outcomes. The current standard of care for postoperative treatment after ocular surgery involves using eye drops daily, which has limited effectiveness mainly due to poor patient adherence. To improve patient experience and outcomes, this article presents the first thermoresponsive hydrogel able to release multiple drug molecules for the application of post-operative treatment following ocular surgery. By varying the parameters such as hydrogel type and polymer hydrophobicity, the drug release profile, duration and dosage can finely be tuned. The approach presented in this article can readily be applied to other applications by simply changing the drug loaded in the drug delivery system.

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Reasons for Early Ocular Hypertension after Uneventful Cataract Surgery

Abstract: Patients with history of glaucoma surgery; high myopia, especially in young age; and DM merit particular observation and treatment for possible IOP elevation following cataract surgery.

Cited by 8 publications

References 30 publications

Recovery after cataract surgery

Recovery after cataract surgery

Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation

Injectable drug depot engineered to release multiple ophthalmic therapeutic agents with precise time profiles for postoperative treatment following ocular surgery

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