Rearranged abietane diterpenoids from the roots of Clerodendrum trichotomum and their cytotoxicities against human tumor cells

Cassane diterpenes with oxygen bridge from the seeds of Caesalpinia sappan

“…All the proton signals were assigned to the corresponding carbons through direct 1 H and 13 C correlations in the HSQC spectrum. The overall 1 H and 13 C NMR spectroscopic data confirmed that 1 was an oxygenated diterpenoid possessing a fused butenolide unit [21][22]. The partial structures were deduced by 1 H\ \ 1 H COSY spectrum and the whole structure was connected on the long-ranged correlations observed in the HMBC spectrum (Fig.…”

New Cassane Diterpenoids from <em>Caesalpinia sappan</em> and Their Antiplasmodial Activity

“…Additionally, the 1 The HSQC spectrum displayed all of the proton signals assigned to the corresponding carbons through direct 1 H and 13 C correlations. The overall 1 H and 13 C NMR spectroscopic data confirmed that 1 is an oxynitride diterpene possessing a fused butenolide unit [9,10], and its entire structure was connected, as confirmed using HSQC, HMBC, and 1 H-1 H-COSY spectra ( Figure 2 showed that the hydroxyl group was β-oriented at C-20, and the methyl group at C-14 and the ethoxy group at C-12 were all α-oriented. The same carbon skeleton with the trans/anti/trans system of three six-membered rings A, B, and C, and the oriented proton at C-8 was β-axial and the oriented protons at C-5/C-9 was α-axial, which are well established on all cassane diterpenes isolated so far from the genus Caesalpinia [3,8,11].…”

Anticancer Activity Of Plant Genus Clerodendrum (Lamiaceae): A Review

“…Lima senyawa yang berhasil diidentifikasi dalam tanaman genus ini yaitu apigenin 7-glucoside, hispidulin, scutellarein-7-O-beta-D-glucuronate, acteoside dan verbascoside menunjukan interaksi dengan protein kanker melalui simulasi penambatan molekul dan berpotensi menimbulkan efek terapi (Gogoi et al 2017 Wang, Zhu, et al 2013;Wang, Xiong, et al 2013;Xu et al 2013 memiliki aktivitas antikanker dari tanaman genus Clerodendrum adalah pheophorbide-related compounds (purpurin 7 dimethyl ester, pheophorbide a, methyl (10S)-hydroxypheophorbide a) (Cheng et al 2001); asam lemak (asam oleat, asam oktadekanoat, asam n-heksadekanoat, dan 6-metil-2-heptanon) (Erukainure et al 2016); asam oleanolik dan clerodinin A (Sannigrahi et al 2012); abitane diterpenoid (trichotomone, trichotomone D, trichotomone F, uncinatone, mandarone E, teuvincenone E, dan trichotomone H) (Wang, Xiong, et al 2013;Wang, Zhu, et al 2013) dan dua senyawa steroid (Xu et al 2013). Mekanisme antikanker beberapa tanaman genus Clerodendrum melalui aktivitas fotositoksisitas (Nakamura et al 1996;Choi et al 2014;Cheng et al 2001), apoptosis, antiproliferatif dan anti-migrasi (Sun et al 2013;Chacko et al 2015).…”

“…Dengan menggunakan CellTiter Glo TM luminescent cell viability assay, nilai IC50 tujuh senyawa abitane diterpenoid pada sel kanker tersebut antara 0,83 -50,99 μM (Wang, Zhu, et al 2013;Wang, Xiong, et al 2013). Dua senyawa steroid yang diisolasi daun C. trichotomum menunjukan aktivitas sitotoksik pada sel HeLa dengan nilai IC50 35,67 dan 28,92 μg/ml menggunakan metode MTT (Xu et al 2013) …”