Reappraising localized juvenile spongiotic gingival hyperplasia

Vargo, Richard J.; Bilodeau, Elizabeth A.

doi:10.1016/j.adaj.2018.10.001

Cited by 13 publications

(16 citation statements)

References 13 publications

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“…Similar to previous reports, the most commonly affected oral site for LJSGH was the anterior maxillary gingiva. The reason for this localization in the anterior maxilla is unknown.…”

Section: Discussionsupporting

confidence: 89%

“…The median age in our series was 13 years old. Together with the previous case series, we conclude that LJSGH is most common in but not limited to the juvenile age range.…”

Section: Discussionsupporting

confidence: 83%

“…Prior reports have described varying female‐to‐male ratios of 1:1 in one series of 24 patients, 2.3:1 in a series with 51 patients, 1:1 in a series of 10 patients, 1.25:1 in a series of 28 patients, 0.5:1 in a series of 21 patients, and 0.5:1 in a series of 3 patients . In our series of 27 patients, we found a slight male predominance with a female to male ratio of 0.6:1.…”

Section: Discussionsupporting

confidence: 67%

“…The majority of patients within other prior publications are also between 11 and 15 years . Vargo et al reported a large age range between 3 and 64 years old, with the median to be 14.5 years old. The median age in our series was 13 years old.…”

Section: Discussionmentioning

confidence: 95%

“…Darling et al, Chang et al, Argyris et al, and Siamantas et al each reported the condition in one adult between the ages of 19 and 40. Vargo et al described 10 adults between the ages of 18 and 64. In our study, we identified three adults with ages of 65, 66, and 72, who presented gingival lesions that were clinically, morphologically, and immunohistochemically identical to LJSGH.…”

Section: Discussionmentioning

confidence: 99%

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Localized juvenile spongiotic gingival hyperplasia: A report of 27 cases

Wang

Jordan

2019

J Cutan Pathol

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Background: Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a poorly understood but distinctive inflammatory hyperplasia occurring in children and young adults. Fewer than 100 cases have been reported since its initial description.Methods: During the period of 2015 to 2018, cases of LJSGH were identified, retrieved and their clinical and histopathological data reviewed.Results: There were 27 cases, with a median age of 13 years (range 7-72 years).Twenty-four of 27 patients were less than 20 years old, and in three cases the patients were over 60 years of age. The most commonly affected site was the anterior maxillary gingiva presenting as a solitary, red, and papillated lesion. Typical microscopic findings included elevated areas of variably acanthotic, spongiotic nonkeratinized epithelium with elongated rete ridges, accompanied by a neutrophilic-rich infiltrate. An abrupt transition between epithelium affected by LJSGH and normal mucosa was characteristic.LJSGH typically exhibited full-thickness epithelial expression of CK19 without expression of estrogen and progesterone receptors. Conclusions:The clinical and histopathologic characteristics of LJSGH are unique and consistent. Despite the name, the condition is not limited to juveniles and can occur in adults. LJSGH in adults and juveniles shares the same spectrum of histopathologic and immunohistochemical findings. K E Y W O R D Sgingival lesion, gingivitis, inflammatory gingival hyperplasia, oral disease

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“…Similar to previous reports, the most commonly affected oral site for LJSGH was the anterior maxillary gingiva. The reason for this localization in the anterior maxilla is unknown.…”

Section: Discussionsupporting

confidence: 89%

“…The median age in our series was 13 years old. Together with the previous case series, we conclude that LJSGH is most common in but not limited to the juvenile age range.…”

Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 95%