2013
DOI: 10.1590/s0004-27302013000900006
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Reappraisal of serum insulin-like growth factor-I (IGF-1) measurement in the detection of isolated and combined growth hormone deficiency (GHD) during the transition period

Abstract: OBJECTIVE: To evaluate the accuracy of serum IGF-1 in the detection of isolated (IGHD) or combined growth hormone deficiency (CGHD) at the transition phase. SUBJECTS AND METHODS: Forty nine patients with GHD during childhood [16 with IGHD (10 men) and 33 with CGHD (24 men); age 23.2 ± 3.5 yrs.] were submitted to an insulin tolerance test (ITT) with a GH peak < 5 µg/L used for the diagnosis of GHD at the transition phase. Pituitary function and IGF-1 measurements were evaluated in the basal sample of the ITT… Show more

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Cited by 7 publications
(4 citation statements)
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“…The disease can begin de novo in adult life (adulthood-onset) or can be diagnosed by GH tests in childhood persisting into adult life (childhood-onset) 22 . In our hands, 56% of patients with idiopathic isolated GHD during childhood had no biochemical criteria for AGHD when re-tested in adult life, whereas 94% of those with combined GHD during childhood persisted with AGHD 23 . Finally, another pivotal concept is related to the severity of the disease.…”
Section: Adult Candidates For Growth Hormone Therapymentioning
confidence: 55%
“…The disease can begin de novo in adult life (adulthood-onset) or can be diagnosed by GH tests in childhood persisting into adult life (childhood-onset) 22 . In our hands, 56% of patients with idiopathic isolated GHD during childhood had no biochemical criteria for AGHD when re-tested in adult life, whereas 94% of those with combined GHD during childhood persisted with AGHD 23 . Finally, another pivotal concept is related to the severity of the disease.…”
Section: Adult Candidates For Growth Hormone Therapymentioning
confidence: 55%
“…Isolated idiopathic GHD diagnosed in children based on biochemical GH tests must be reevaluated during transition into adult life. A Brazilian study reported that only 31% of the children with GHD persisted with GHD when retested, with an IGF-I cutoff value of 110 ng/mL presenting 94.5% sensitivity and 100% specificity for diagnosis of AGHD in the transition period (99). Noteworthy, short children treated with GH for non-GHD pediatric indications (e.g., Turner syndrome, idiopathic short stature, small for gestational age, etc.)…”
Section: Gh Deficiency (Ghd) In Adultsmentioning
confidence: 99%
“…Importantly, normal IGF-I levels in adults with pituitary adenoma do not exclude the diagnosis of GH deficiency because nearly half of adult patients with GH deficiency may have normal levels of IGF-I (40). Nevertheless, in the presence of three pituitary hormone deficiencies, low IGF-I values are specific predictors of GH deficiency (41,42). If at least three deficiencies do not occur, GH liberation testing should be performed.…”
Section: Diagnosis Clinical Presentationmentioning
confidence: 99%