Reappraisal of Astigmatism Induced by Periocular Capillary Hemangioma and Treatment with Intralesional Corticosteroid Injection

Refractive and structural changes in infantile periocular capillary haemangioma treated with propranolol

“…13 It can cause ptosis, displacement of the globe, and mechanical deformation of the immature sclera and cornea, leading to anisometropic astigmatism and refractive amblyopia. [13][14][15] In severe cases, it can cause disfiguring proptosis, exposure keratitis, compressive optic neuropathy, and facial/lid deformation. 16,17 First-line therapy with corticosteroids: systemic (oral and intravenous), through local intralesional injection, periorbital infusion, or combined intralesional and posterior sub-Tenon's infusion yielded anatomical and refractive improvement.…”

Rapid Regrowth of a Capillary Hemangioma of the Thoracic Spinal Cord

“…Recently, several agents such as corticosteroids, interferon, and b-blockers have been reported to be effective for the treatment of capillary hemangioma in the skin or soft tissues. 6,15,27,30,31) In addition to skin or soft-tissue lesions, residual tumor has been reported to show regression after medical treatment in patients with capillary hemangioma of the CNS. 3) Furthermore, the effectiveness of radiation therapy for capillary hemangiomas has been established.…”

Educational paper: therapy of infantile haemangioma—history and current state (part II)

“…In 2013, Nieuwenhuis et al showed that (intermittent) short course systemic glucocorticosteroid therapy is a more effective and safer treatment for IH, with a substantially lower cumulative dose of glucocorticosteroids compared to prolonged low-dose therapy [51]. Some IHs, for example peri-ocular IHs, respond better to intra-lesionally administered corticosteroids, with success rates of up to 64 % [50,63,64]. The obvious advantage of this method is that it is very safe; fewer side effects occur because often just one injection is needed.…”