Reagentless Quantum-Rate-Based Electrochemical Signal of Graphene for Detecting SARS-CoV-2 Infection Using Nasal Swab Specimens

Garrote, Beatriz Lucas; Lopes, Laís C.; Pinzón, Edgar F.; Mendonça-Natividade, Flávia Costa; Martins, Ronaldo B.; Santos, Alexandre Leme Godoy dos; Arruda, Eurico; Bueno, Paulo Roberto

doi:10.1021/acssensors.2c01016

Cited by 9 publications

(4 citation statements)

References 36 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ultimately, the theory allows us to conclude that an AC architecture for transistors must perform with much better efficiency (for the quantum transport of information and energy) than our traditional DC mode of using logical transistor operations. Apparently, nature has already accomplished this through the transport of electrons within electrochemical energy levels in complex biological structures, allowing us to predict an avenue of possibilities for using graphene in biological sensing application, for instance, see ref .…”

Section: Discussionmentioning

confidence: 99%

Quantum Rate Theory for Graphene

Bueno

Miranda

2022

J. Phys. Chem. C

Self Cite

View full text Add to dashboard Cite

The quantum rate theory predicts the electron transfer rate between quantum states governed by the ratio between the quantum conductance and capacitance (Phys. Chem. Chem. Phys. 2020, 22, 26109−26112). This rate is important not only for describing the quantumness of the electron transfer of electrochemical reactions but also for understanding electron transport in molecular electronics (Phys. Chem. Chem. Phys. 2020, 22 (19), 10828−10832). Additionally, this quantum rate principle is applicable for describing conductive and capacitive V-shapes of graphene (Carbon 2021, 184 821−827). In the present work, we demonstrate the relationship between the quantum rate theory for a single-layer graphene and the relativistic quantum mechanical theory of electrons according to the Dirac equation. As the merger of quantum mechanics and relativity theory, quantum rate theory is the key to analyzing quantum electrodynamics in two-dimensional structures (e.g., honeycomb-like carbon such as graphene) using an inexpensive benchtop electrochemical setup. In this study, the quantum rate model for graphene is introduced along with its applicability to the diffusionless electrochemical transport of electrons, as exemplified for molecular films comprising redox switches. This didactic approach demonstrates that the best means of conducting electron transport in graphene is the AC mode of electric current modulation, in which electric displacement current is imperative. A maximum quantum rate of electron transport occurs at the Dirac point, where net carrier concentrations are at their minimum, in contrast to the traditional DC mode of modulating conductance. This analysis opens an avenue of possibilities for fabricating quantum devices with electronic semiconducting accuracy, for example, biological sensors in complex environments.

show abstract

Section: Discussionmentioning

confidence: 99%

Quantum Rate Theory for Graphene

Bueno

Miranda

2022

J. Phys. Chem. C

Self Cite

View full text Add to dashboard Cite

show abstract

“…Second, the nucleic acid biosensors are efficient for early diagnosis of genetic diseases, e.g., miRNA21 (breast cancer), as well as mass screening of coronavirus disease 2019. − Indeed, the DNA aptamer modified graphene transistor promotes the detection of viruses in several minutes for self-test at home . Recently, CRISPR technique was integrated with transistor platform for breaking the detection limit to attomole per liter level …”

Section: Electronic Tongue For Tastementioning

confidence: 99%

Applications of Graphene in Five Senses, Nervous System, and Artificial Muscles

et al. 2023

View full text Add to dashboard Cite

Graphene remains of great interest in biomedical applications because of biocompatibility. Diseases relating to human senses interfere with life satisfaction and happiness. Therefore, the restoration by artificial organs or sensory devices may bring a bright future by the recovery of senses in patients. In this review, we update the most recent progress in graphene based sensors for mimicking human senses such as artificial retina for image sensors, artificial eardrums, gas sensors, chemical sensors, and tactile sensors. The brain-like processors are discussed based on conventional transistors as well as memristor related neuromorphic computing. The brain−machine interface is introduced for providing a single pathway. Besides, the artificial muscles based on graphene are summarized in the means of actuators in order to react to the physical world. Future opportunities remain for elevating the performances of human-like sensors and their clinical applications.

show abstract

“…The response of the biosensor was assessed by real-time monitoring of the resistance change caused by antigen-antibody interaction with a LOD value of 10 fM. For the purpose of detecting SARS-CoV-2 infection using nasal swab specimens, Garrote et al [ 45 ] created an AC GFET that acted as a reagent-less quantum-rate-based electrochemical biosensing platform. According to the quantum-rate model, the frequency of electron transport inside molecular structures, as measured in graphene that has biological receptors, may be employed as a transducer signal at the interface with attomole-level sensitivity for biosensing.…”

Section: Applications Of Carbon Nanomaterials Against Covid-19mentioning

confidence: 99%

The Emergence of Carbon Nanomaterials as Effective Nano-Avenues to Fight against COVID-19

Sengupta¹,

Hussain

2023

Materials

View full text Add to dashboard Cite

COVID-19 (Coronavirus Disease 2019), a viral respiratory ailment that was first identified in Wuhan, China, in 2019, and then expanded globally, was caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The severity of the illness necessitated quick action to cease the virus’s spread. The best practices to avert the infection include early detection, the use of protective clothing, the consumption of antiviral medicines, and finally the immunization of the patients through vaccination. The family of carbon nanomaterials, which includes graphene, fullerene, carbon nanotube (CNT), and carbon dot (CD), has a great deal of potential to effectively contribute to each of the main trails in the battle against the coronavirus. Consequently, the recent advances in the application of carbon nanomaterials for containing and combating the SARS-CoV-2 virus are discussed herein, along with their associated challenges and futuristic applicability.

show abstract

Reagentless Quantum-Rate-Based Electrochemical Signal of Graphene for Detecting SARS-CoV-2 Infection Using Nasal Swab Specimens

Cited by 9 publications

References 36 publications

Quantum Rate Theory for Graphene

Quantum Rate Theory for Graphene

Applications of Graphene in Five Senses, Nervous System, and Artificial Muscles

The Emergence of Carbon Nanomaterials as Effective Nano-Avenues to Fight against COVID-19

Contact Info

Product

Resources

About