2016
DOI: 10.14814/phy2.12808
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Abstract: Previous studies have reported a vasoconstrictor response in the radial artery during a cuff‐induced low‐flow condition, but a similar low‐flow condition in the brachial artery results in nonuniform reactivity. This variable reactivity to low‐flow influences the subsequent flow‐mediated dilatation (FMD) response following cuff‐release. However, it is uncertain whether reactivity to low‐flow is important in data interpretation in clinical populations and older adults. This study aimed to determine the influence… Show more

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Cited by 9 publications
(18 citation statements)
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“…The association between an enhanced vasoconstrictor response during ischaemia and a blunted maximal dilation during reactive hyperaemia was previously observed among both healthy controls and participants with multiple CVD risk factors (e.g. hypertension, diabetes and dyslipidemia) (Harrison et al ., ; Aizawa et al ., ). Gori and colleagues observed that an enhanced radial L‐FMC and lower radial FMD occurred following an acute, 4‐min bout of isometric exercise among healthy volunteers (Gori et al ., ).…”
Section: Discussionmentioning
confidence: 97%
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“…The association between an enhanced vasoconstrictor response during ischaemia and a blunted maximal dilation during reactive hyperaemia was previously observed among both healthy controls and participants with multiple CVD risk factors (e.g. hypertension, diabetes and dyslipidemia) (Harrison et al ., ; Aizawa et al ., ). Gori and colleagues observed that an enhanced radial L‐FMC and lower radial FMD occurred following an acute, 4‐min bout of isometric exercise among healthy volunteers (Gori et al ., ).…”
Section: Discussionmentioning
confidence: 97%
“…Spiro and colleagues further observed that, following elective percutaneous coronary intervention), a profound reduction in brachial FMD occurred in conjunction with an increase in L‐FMC (Spiro et al ., ). These results imply that brachial reactivity during low flow may be an essential contributing factor in determining the magnitude of FMD, underscoring the importance of accounting for L‐FMC in traditional vascular assessments to provide a more comprehensive and accurate assessment of endothelial function (Harrison et al ., ; Aizawa et al ., ). However, the association of increased L‐FMC with reduced magnitude FMD requires further investigation as findings from our study and others have not provided evidence of a causal relationship.…”
Section: Discussionmentioning
confidence: 97%
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“…Recording of brachial artery image and blood velocity was re‐started 30 s before cuff deflation (Aizawa et al . ) and continued until 5 min after deflation. A subset of participants in Exeter (young, n = 14; older, n = 29) had endothelium independent dilatation assessed using sublingual glyceryl trinitrate (GTN) spray (0.4 mg) after a 15 min rest.…”
Section: Methodsmentioning
confidence: 99%