Reactivity of Benzo[b]furans: A Full Perspective

Heravi, Majid M.; Zadsirjan, Vahideh; Dehghani, Mahzad

doi:10.2174/1385272820666151026224401

Cited by 11 publications

(10 citation statements)

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“…Thus, we had to divide the rest of this vast subject into three reviews. In our two recent reviews, we disclosed the full perspective of reactivity of benzofurans 96 and advances in the synthesis of biologically potent compounds bearing at least one benzo [b]furan moiety in their structures, respectively. 97 In the present review, we collated the published reports on the total synthesis of natural products containing at least one benzofuran moiety in their complex structures.…”

Section: -39mentioning

confidence: 99%

Total synthesis of natural products containing benzofuran rings

et al. 2017

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Research on natural products containing benzofuran has remarkably increased during the past few decades.Newly isolated natural products with complex structures are being studied, characterized and screened for possible biological activities. Several of such compounds have exhibited various biological activities, thus their total syntheses have attracted much attention from synthetic organic chemists. In this review, we aim to highlight the origins, structures, biological potencies, and synthetic approaches of those natural products bearing at least one benzofuran in their complex structures. Furthermore, we especially focus on the step in which this key heterocycle is installed during the total synthesis of a natural product as the desired target.

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Section: -39mentioning

confidence: 99%

Total synthesis of natural products containing benzofuran rings

et al. 2017

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“…The latter after several steps gave compound 31. Thus, total synthesis of (À )-indolactam V (31) was accomplished from 4-bromo-1H-indole (24) in eight steps (Scheme 5).…”

Section: Cu (I) Saltsmentioning

confidence: 99%

Catalytic Function of Cu (I) and Cu (II) in Total Synthesis of Alkaloids

et al. 2021

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Recently, Cu-catalyzed carbon-carbon and carbon (sp 2 )-nitrogen bond formation have attracted much attention. Nowadays, they are widely being applied to the total synthesis of an extensive assortment of natural products with complex structures. Natural products chemistry is a discrete part of chemical research, which has been significant in the history of chemistry, the sourcing of substances in early preclinical drug discovery research, pharmacology and discovery of folk medicine. Alkaloids are a class of natural product that contains at least one nitrogen atom. They have diverse and important physiological effects on humans and other animals. In fact, as many as one-quarter of higher plants are estimated to contain alkaloids, of which several thousand (approximately 12000) different types have so far been identified. In this review, we try underscore the total synthesis of naturally occurring alkaloids in which Cu-promoted reaction is at least one of the vital step. Indeed, in this comprehensive review, the impact of Cu-catalyzed cross-coupling reactions in the total synthesis of natural products with a prominence on the evolution of strategies due to copper catalysis will be generally surveyed.

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“…[35][36][37] For the racemic and later asymmetric conjugate addition (ACA) of alkenylzirconium species 5 to various Michael acceptors, Rh(I) catalysis became more convenient than Ni(II) catalysis. 38,39 The asymmetric version of the Rh-catalyzed conjugate addition of alkenylzirconium species 5 was presented by Oi I. Némethová, R. Šebesta…”

Section: Asymmetric Conjugate Additionmentioning

confidence: 99%

Are Organozirconium Reagents Applicable in Current Organic Synthesis?

Némethová

Šebesta

2020

Synthesis

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The search for mild, user-friendly, easily accessible, and robust organometallic reagents is an important feature of organometallic chemistry. Ideally, new methodologies employing organometallics should be developed with respect to practical applications in syntheses of target compounds. In this short review, we investigate if organozirconium reagents can fulfill these criteria. Organozirconium compounds are typically generated via in situ hydrozirconation of alkenes or alkynes with the Schwartz reagent. Alkyl and alkenylzirconium reagents have proven to be convenient in conjugate additions, allylic substitutions, cross-coupling reactions, and additions to carbonyls or imines. Furthermore, the Schwartz reagent itself is a useful reducing agent for polar functional groups.1 Introduction2 Synthesis and Generation of the Schwartz Reagent3 Structure and Properties of Cp2Zr(H)Cl4 Reactivity of Organozirconium Reagents4.1 Asymmetric Conjugate Addition4.2 Asymmetric Allylic Alkylations4.3 Desymmetrization Reactions4.4 Cross-Coupling Reactions4.5 1,2-Additions5 Conclusions

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Reactivity of Benzo[b]furans: A Full Perspective

Abstract: Reactivity of Benzo[b]furans: A Full Perspective -[305 refs.]. -(HERAVI, M. M.; ZADSIRJAN, V.; DEHGHANI, M.; Curr.

Cited by 11 publications

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Total synthesis of natural products containing benzofuran rings

Total synthesis of natural products containing benzofuran rings

Catalytic Function of Cu (I) and Cu (II) in Total Synthesis of Alkaloids

Are Organozirconium Reagents Applicable in Current Organic Synthesis?

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