Reactive perforating collagenosis. Experimental production of the lesion

Bovenmyer, D. A.

doi:10.1001/archderm.102.3.313

Cited by 35 publications

(37 citation statements)

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“…28 similar observations were later published or recognised [1,2,7,[10][11][12][13], The eruption begins in childhood, is composed of numerous pinhead-sized, skin-coloured papules, reaching progressively 5-6 mm in diameter and having a central umbilication containing keratinous material. Within 6-8 weeks each indi vidual lesion disappears, leaving a small area of temporary pigmentation.…”

Section: Discussionsupporting

confidence: 58%

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Transepidermal Elimination of Traumatically Altered Collagen

Delacrétaz¹,

Gattlen²

1976

Dermatology

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Section: Discussionsupporting

confidence: 58%

“…Within 6-8 weeks each indi vidual lesion disappears, leaving a small area of temporary pigmentation. New papules appear steadily; the microtraumatic aetiology is generally ad mitted and confirmed by the experimental production of typical lesions in three cases [2,5].…”

Section: Discussionmentioning

confidence: 63%

Transepidermal Elimination of Traumatically Altered Collagen

Delacrétaz¹,

Gattlen²

1976

Dermatology

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“…The (isomorphic re sponse) Koebner phenomenon is promi nent. Bovenmyer [1] produced typical le sions by scratching his patient's forearm (sun-exposed) with a 25-gauge hypodermic needle. The same test made in the upper part of the thigh (nonsun-exposed) was negative (phototraumatism).…”

Section: Discussionmentioning

confidence: 99%

Reactive Perforating Collagenosis and Phototraumatism

Berlin

Goldberg

1985

Dermatology

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Two pairs of siblings are reported suffering from reactive perforating collagenosis. The clinical features were recurrent crusted papules with a central keratinaceous plug. The plug was sometimes encircled by a narrow yellowish ring and a wider red ring, giving the appearance of a cockade. Lesions recurred spontaneously or were provoked by superficial injury to sun-exposed skin (phototraumatism). There were no other changes in the general health of these patients.

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“…im Rahmen eines Diabetes mellitus oder bei Lymphomen induziert werden [41,42]. Ebenso ist die experimentelle Induktion von typischen Läsionen in gesunder Haut bei einer an einer perforierenden Kollagenose leidenden Patientin gelungen [4]. Bei Vorliegen eines Diabetes mellitus wurde als zusätzlich prädisponierender Faktor die diabetische Vaskulopathie mit einer Minderdurchblutung dermaler Strukturen angesehen [8].…”

Section: Besprechungunclassified

Erworbene reaktiv perforierende Dermatose

et al. 1999

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Perforating disorders represent a heterogenous group of dermatoses characterized by transepithelial elimination of dermal structures. Primary perforating disorders should be distinguished from secondary perforating disorders in which perforation with transepithelial elimination is a rare component of a variety of dermatoses. The primary perforating disorders are hyperkeratosis follicularis et parafollicularis in cutem penetrans (Kyrle's disease), elastosis perforans serpiginosa and perforating folliculitis. Acquired reactive perforating dermatosis (also known as acquired reactive perforating collagenosis) together with the hereditary variant of the reactive perforating collagenosis represent further examples of the primary perforating disorders. We report on 84 year old and 96 year old female patients with an acquired perforating dermatosis. Both of the patients additionally showed diabetes and hyperuricemia. Oral administration of allopurinol (100 mg daily) led to a healing of the disseminated skin lesions in 1-2 weeks. After a follow-up period of 6 months, both patients were in complete remission. On one hand, these results prove again the existence and the severity of this disease, and on the other hand suggest an immunomodulating or differentiation-promoting action in addition to the uricostatic effect of allopurinol.

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Reactive perforating collagenosis. Experimental production of the lesion

Cited by 35 publications

References 0 publications

Transepidermal Elimination of Traumatically Altered Collagen

Transepidermal Elimination of Traumatically Altered Collagen

Reactive Perforating Collagenosis and Phototraumatism

Erworbene reaktiv perforierende Dermatose

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