Reactive Oxygen Species-Activated Nanomaterials as Theranostic Agents

Kim, Kye S; Lee, Dongwon; Song, Chul-Gyu; Kang, Peter M.

doi:10.2217/nnm.15.108

Cited by 75 publications

(57 citation statements)

References 110 publications

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“…Indeed, oxidative stress induced for NPs have been shown. Those cell responses need to be taken in consideration when evaluating possible cytotoxicity effects induced by NPs [42, 43]. …”

Section: Resultsmentioning

confidence: 99%

Real-time, label-free monitoring of cell viability based on cell adhesion measurements with an atomic force microscope

et al. 2017

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BackgroundThe adhesion of cells to an oscillating cantilever sensitively influences the oscillation amplitude at a given frequency. Even early stages of cytotoxicity cause a change in the viscosity of the cell membrane and morphology, both affecting their adhesion to the cantilever. We present a generally applicable method for real-time, label free monitoring and fast-screening technique to assess early stages of cytotoxicity recorded in terms of loss of cell adhesion.ResultsWe present data taken from gold nanoparticles of different sizes and surface coatings as well as some reference substances like ethanol, cadmium chloride, and staurosporine. Measurements were recorded with two different cell lines, HeLa and MCF7 cells. The results obtained from gold nanoparticles confirm earlier findings and attest the easiness and effectiveness of the method.ConclusionsThe reported method allows to easily adapt virtually every AFM to screen and assess toxicity of compounds in terms of cell adhesion with little modifications as long as a flow cell is available. The sensitivity of the method is good enough indicating that even single cell analysis seems possible.Electronic supplementary materialThe online version of this article (doi:10.1186/s12951-017-0256-7) contains supplementary material, which is available to authorized users.

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“…Indeed, oxidative stress induced for NPs have been shown. Those cell responses need to be taken in consideration when evaluating possible cytotoxicity effects induced by NPs [42, 43]. …”

Section: Resultsmentioning

confidence: 99%

Real-time, label-free monitoring of cell viability based on cell adhesion measurements with an atomic force microscope

et al. 2017

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“…Besides ROS-scavenging inorganic nanoparticles, organic nanoparticles with intrinsic antioxidant activities have been emerging as a potential platform for the treatment of numerous diseases associated with inflammatory disorders (Kim K. S. et al, 2015;Zhu and Su, 2017;Kwon et al, 2019). Several types of organic nanoparticles have shown higher antioxidative advantages over conventional antioxidants and radical scavengers, owing to their predominant properties in terms of pharmacokinetics, biodistribution, delivery efficiency, and robust scavenging capabilities of multiple radicals Ferreira et al, 2018;Ye et al, 2019;Zafar et al, 2019).…”

Section: Organic Nanoparticles With Intrinsic Antioxidant Activitiesmentioning

confidence: 99%

Antioxidant Nanotherapies for the Treatment of Inflammatory Diseases

Chen

et al. 2020

Front. Bioeng. Biotechnol.

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Reactive oxygen species (ROS) are essential in regulating various physiological functions. However, overproduction of ROS is implicated in the pathogenesis of various inflammatory diseases. Antioxidant therapy has thus represented an effective strategy for the treatment of oxidative stress relevant inflammatory diseases. Conventional anti-oxidative agents showed limited in vivo effects owing to their non-specific distribution and low retention in disease sites. Over the past decades, significant achievements have been made in the development of antioxidant nanotherapies that exhibit multiple advantages such as excellent pharmacokinetics, stable anti-oxidative activity, and intrinsic ROS-scavenging properties. This review provides a comprehensive overview on recent advances in antioxidant nanotherapies, including ROS-scavenging inorganic nanoparticles, organic nanoparticles with intrinsic antioxidant activity, and drug-loaded anti-oxidant nanoparticles. We highlight the biomedical applications of antioxidant nanotherapies in the treatment of different inflammatory diseases, with an emphasis on inflammatory bowel disease, cardiovascular disease, and brain diseases. Current challenges and future perspectives to promote clinical translation of antioxidant nanotherapies are also briefly discussed.

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“…During IRI, the burst of ROS also amplifies inflammatory responses that induce the release of proinflammatory cytokines and chemokines including tumor necrosis factor (TNF)‐α, interleukin (IL)‐1β, IL‐6, and monocyte chemoattractant protein 1 (MCP‐1/CCL2). The events result in congestion of the microcirculation (known as the no‐reflow phenomenon), and endothelial dysfunction . Hydrogen peroxide, H 2 O 2 , the most abundant form of ROS, gives rise to highly toxic hydroxyl radicals via the Haber‐Weiss reaction, facilitated by the increased availability of free iron accompanying ischemia .…”

Section: Introductionmentioning

confidence: 99%

“…The events result in congestion of the microcirculation (known as the no‐reflow phenomenon), and endothelial dysfunction . Hydrogen peroxide, H 2 O 2 , the most abundant form of ROS, gives rise to highly toxic hydroxyl radicals via the Haber‐Weiss reaction, facilitated by the increased availability of free iron accompanying ischemia . Thus, neutralizing the overproduction of H 2 O 2 may represent an efficient and novel strategy to prevent oxidative stress in IRI .…”

Section: Introductionmentioning

confidence: 99%

Targeting of intragraft reactive oxygen species by APP-103, a novel polymer product, mitigates ischemia/reperfusion injury and promotes the survival of renal transplants

Minami

Bae²,

Uehara

et al. 2020

American Journal of Transplantation

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Inflammatory responses associated with ischemia/reperfusion injury (IRI) play a central role in alloimmunity and transplant outcomes. A key event driving these inflammatory responses is the burst of reactive oxygen species (ROS), with hydrogen peroxide (H 2 O 2 ) as the most abundant form that occurs as a result of surgical implantation of the donor organ. Here, we used a syngeneic rat renal transplant and IRI model to evaluate the therapeutic properties of APP-103, a polyoxalate-based copolymer molecule containing vanillyl alcohol (VA) that exhibits high sensitivity and specificity toward the production of H 2 O 2 . We show that APP-103 is safe, and that it effectively promotes kidney function following IRI and survival of renal transplants.APP-103 reduces tissue injury and IRI-associated inflammatory responses in models of both warm ischemia (kidney clamping) and prolonged cold ischemia (syngeneic renal transplant). Mechanistically, we demonstrate that APP-103 exerts protective

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Reactive Oxygen Species-Activated Nanomaterials as Theranostic Agents

Cited by 75 publications

References 110 publications

Real-time, label-free monitoring of cell viability based on cell adhesion measurements with an atomic force microscope

Real-time, label-free monitoring of cell viability based on cell adhesion measurements with an atomic force microscope

Antioxidant Nanotherapies for the Treatment of Inflammatory Diseases

Targeting of intragraft reactive oxygen species by APP-103, a novel polymer product, mitigates ischemia/reperfusion injury and promotes the survival of renal transplants

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