Reactivation of latently infected HIV-1 viral reservoirs and correction of aberrant alternative splicing in the LMNA gene via AMPK activation: Common mechanism of action linking HIV-1 latency and Hutchinson–Gilford progeria syndrome

Finley, Jahahreeh

doi:10.1016/j.mehy.2015.06.003

Cited by 9 publications

(4 citation statements)

References 188 publications

(231 reference statements)

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“…ASF/SF2 is known to inhibit HIV-1 replication due to excessive splicing of HIV-1 mRNAs [Finley, 2015;Jablonski and Caputi, 2009;Jacquenet et al, 2005;Ropers et al, 2004].Less is known about the role(s) of ASF/SF2 at the transcription level. A recent study reported that ASF/SF2 inhibits HIV-1…”

Section: Discussionmentioning

confidence: 99%

“…Thus we believe that ASF/SF2 may be a general negative factor regulating the transcription elongation mediated by CycT1a/1b via regulating the Cyclin T1 splicing. ASF/SF2 is known to inhibit HIV-1 replication due to excessive splicing of HIV-1 mRNAs [Ropers et al, 2004;Jacquenet et al, 2005;Jablonski and Caputi, 2009;Finley, 2015]. Less is known about the role(s) of ASF/SF2 at the transcription level.…”

Section: Discussionmentioning

confidence: 99%

“…ASF/SF2 is known to inhibit HIV‐1 replication due to excessive splicing of HIV‐1 mRNAs [Ropers et al, ; Jacquenet et al, ; Jablonski and Caputi, ; Finley, ]. Less is known about the role(s) of ASF/SF2 at the transcription level.…”

Section: Discussionmentioning

confidence: 99%

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Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine‐Arginine‐Rich Protein ASF/SF2

Zhou

Gao

Hou

et al. 2017

J of Cellular Biochemistry

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Positive transcription elongation factor-b (P-TEFb) is required for the release of RNA polymerase II (RNAPII) from its pause near the gene promoters and thus for efficient proceeding to the transcription elongation. It consists of two core subunits-CDK9 and one of T-typed or K-typed cyclin, of which, cyclin T1/CDK9 is the major and most studied combination. We have previously identified a novel splice variant of cyclin T1, cyclin T1b, which negatively regulates the transcription elongation of HIV-1 genes as well as several host genes. In this study, we revealed the serine-arginine-rich protein, ASF/SF2, as a regulatory factor of the alternative splicing of cyclin T1 gene. ASF/SF2 promotes the production of cyclin T1b versus cyclin T1a and regulates the expression of cyclin T1-depedent genes at the transcription level. We further found that a cis-element on exon 8 is responsible for the skipping of exon 7 mediated by ASF/SF2. Collectively, ASF/SF2 is identified as a splicing regulator of cyclin T1, which contributes to the control of the subsequent transcription events. J. Cell. Biochem. 118: 4020-4032, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine‐Arginine‐Rich Protein ASF/SF2

Zhou

Gao

Hou

et al. 2017

J of Cellular Biochemistry

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“…AMPK, during this FFA exposure, down-regulates novel lipid molecules generation [122,353] and interlocks mTOR, Nrf2, GLuT4, and PI3K to this mechanism [209,228,252,354,355], and GSK3β to mitochondrial dysfunction [356], a momentous event when hyperlipidemia engender [61,63]. Moreover, if the AMPK/mTOR pathway malfunction is prolonged, the hyperlipidemic conditions may be explicit [313], which are activated by natural herbal mediators, polyphenols [357,358], and dietary anti-oxidant [359].…”

Section: Ampk and Polyphenolsmentioning

confidence: 99%

Therapeutic Properties of Polyphenols Affect AMPK Molecular Pathway in Hyperlipidemia

Sotoudeheian¹,

Hoseini²,

Mirahmadi³

2023

Preprint

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Hyperlipidemia is the fat particles excess in the serum. Hyperlipidemia increases the mortality rate that occurs with other metabolic disorders. Hyperlipidemia is classified into familial and acquired subgroups. Moreover, Hyperlipidemia etiology is based on environmental or genetic factors. For instance, abnormal HMG-CoA regulation down-regulates ubiquitin ligase and targets variable oxidative stress-related condition proteins. There has been proven reactive oxygen species (ROS) overshoot happens during hyperlipidemia occurrence. OS, directly and indirectly, regulates molecular cascades within the cell and leads to gene expression alteration. At this molecular juncture, AMPK is affected by ROS. AMPK is a serine-threonine kinase and a critical energy balance. Low energy conditions result in AMPK activation due to the down-regulation of protein and lipid synthesis. Furthermore, ER stress and activated unfolded protein proteasomal response and autophagy are AMPK mediated. Polyphenols are widespread dietary plant-based compounds that regulate gene expression and signal conduction. Through the hyperlipidemic state, FFAs releasing indirectly connect to AMPK/NF-κB pathway then polyphenols target them. AMPK, during this FFA exposure, down-regulates de novo lipid molecules generation. Likewise, if AMPK/mTOR pathway failure is prolonged, the hyperlipidemic state may be explicit, activated by natural herbal mediators, e.g., polyphenols. Polyphenols activate the AMPK signaling pathway and influence lipid metabolism. Polyphenol-mediated AMPK activation results in lipogenesis inhibition and lipophagy. Cholesterol efflux mediated polyphenols lipid-lowering effects, accessing LXR pathway. All these clues persist on direct or indirect AMPK-related polyphenolic anti-hyperlipidemic effects.

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Oocyte activation and latent HIV-1 reactivation: AMPK as a common mechanism of action linking the beginnings of life and the potential eradication of HIV-1

Finley¹

2016

Medical Hypotheses

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Reactivation of latently infected HIV-1 viral reservoirs and correction of aberrant alternative splicing in the LMNA gene via AMPK activation: Common mechanism of action linking HIV-1 latency and Hutchinson–Gilford progeria syndrome

Cited by 9 publications

References 188 publications

Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine‐Arginine‐Rich Protein ASF/SF2

Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine‐Arginine‐Rich Protein ASF/SF2

Therapeutic Properties of Polyphenols Affect AMPK Molecular Pathway in Hyperlipidemia

Oocyte activation and latent HIV-1 reactivation: AMPK as a common mechanism of action linking the beginnings of life and the potential eradication of HIV-1

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