“…When there is no motivation to approach a danger (hence, the BIS is not engaged), stimuli that can simply be avoided elicit the following defensive behaviors, according to defensive distance, or perceived threat, highto-low, respectively: Flight and Active Avoidance; and for stimuli that cannot be easily avoided, Fight and Freeze. These prototypical ethoexperimental animal responses have been modelled in human beings with some success (e.g., Blanchard, Hynd, Minke, Minemoto, & Blanchard, 2001;Perkins & Corr, 2006). There is now also evidence that such human behavioral analogues of rodent defensive paradigms are sensitive to drugs used to treat fear and anxiety in human patients (Perkins et al, 2009(Perkins et al, , 2013.…”