Reaction of arylidenehydrazono-4-aryl-2,3-dihydrothiazole-5-carbonitriles with diethyl acetylenedicarboxylate. Synthesis of (Z)-ethyl 2-[((Z)-2-(E)-arylidenehydrazono)-4-oxo-thiazolidine-5-ylidene]acetates. NMR investigation

Reaction of N,N-disubstituted hydrazinecarbothioamides with 2-bromo-2-substituted acetophenones

“…18,19 Previously, we utilized by N,N'-disubstituted-hydrazinecarbothioamides in heterocyclic synthesis, such as 1,3-thiazin-2-ylidene-substituted hydrazides and 1,2,4-triazolo [3,4-b]-1,3-thiazine-5-carboxylates 20 . Continuation of our research program included the synthesis of various thiazoles, [21][22][23][24][25][26] we herein report the results of our investigation on the reactions of symmetrical hydrazinecarbothioamides 1a-d with 2-bromoacetophenones 2a,b.…”

Thiazolidine‐4‐ones from Thiocarbohydrazides

“…have reported the synthesis of thiazolidinones 14a , b via gentle heating of different thiosemicarbazones 5g , h with malonitrile derivatives 8 to form thiazoles 9a , b , which upon reaction with diethyl acetylenedicarboxylate (DEAD, 4b ) gave the desired thiazolidinones through the intermediates 10–13 (Scheme ). Isolation of compounds 1 1 a , b proved the reaction sequence .…”

“…Also, higher yields of (hydrazono)‐4‐thiazolidinone‐5‐ylidene] acetates 14a–f were obtained from refluxing solutions of thiosemicarbazones 5e , g–k with DEAD 4b in methanol or microwave irradiation of the two starting materials without solvent via intermediate 15a–f (Scheme ) .…”

New Pyrimidine‐2‐thiones from Reactions of Amidrazonethiols with 2‐Amino‐1,1,2‐ethenetricarbonitrile and Investigation of Their Antitumor Activity

“…Aly et al . have recently reported a facile synthesis of thiazolidines through one‐pot three‐component reaction of equimolar amounts of thiosemicarbazones, arylidene malononitriles, and diethyl acetylenedicarboxylate under prolonged reflux in acetic acid . It was also reported that N ‐substituted hydrazino‐carbothioamides reacted with dibenzoylacetylene to give thiazine‐hydrazides , and that N ‐imidoylthioureas reacted with 1,1,2,2‐tetracyanoethylene to give thiadiazines .…”

“…Schiff bases derived from thiosemicarbazides are of significant interest not only for their pharmacological properties [3][4][5][6] but also for their capacity for chemical recognition of anions and metals of biological and environmental importance [7][8][9][10]. Aly et al have recently reported a facile synthesis of thiazolidines through one-pot three-component reaction of equimolar amounts of thiosemicarbazones, arylidene malononitriles, and diethyl acetylenedicarboxylate under prolonged reflux in acetic acid [11]. It was also reported that N-substituted hydrazino-carbothioamides reacted with dibenzoylacetylene to give thiazine-hydrazides [12], and that N-imidoylthioureas reacted with 1,1,2,2tetracyanoethylene to give thiadiazines [13].…”