volume 319, issue 3, PG303-G308 2020
DOI: 10.1152/ajpgi.00385.2019
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Abstract: The purpose of this study was to demonstrate the aberrant metabolism of bile acids in patients with cholesterol gallstone and explore for its underlying mechanisms.The composition of bile acids collected from the patients with cholelithiasis and the control individuals was analyzed by LC-MS. The expression of genes regulating the metabolism of bile acids were quantitatively determined by real-time PCR or Western blotting. Cholesterol saturation index of patients with gallstone was significantly higher than th…

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