2018
DOI: 10.18632/aging.101589
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Abstract: Frontal cortical dysfunction is a fundamental pathology contributing to age-associated behavioral and cognitive deficits that predispose older adults to neurodegenerative diseases. It is established that aging increases the risk of frontal cortical dysfunction; however, the underlying molecular mechanism remains elusive. Here, we used an integrative meta-analysis to combine five frontal cortex microarray studies with a combined sample population of 161 younger and 155 older individuals. A network-based analysi… Show more

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Cited by 6 publications
(2 citation statements)
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References 48 publications
(42 reference statements)
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“…Specific functions of the downregulated proteins are provided in Table S3. , Biological functions of downregulated proteins consist of trafficking and cell morphology (AHSG, AP2A2, COL1A2, COL4A2, DCN, FAT1, KIF5B, LLGL1, NID1, NUMA1, SEPT2, and TPM4) biochemical and binding activities (ALDOA, ANXA5, ASS1, ATP1A2, CKB, CLIC1, LOXL3, PLOD1, PSAP, PYGB, SLC9A3R1, and SPOCK1), synaptic regulation (CTTNNA2 and SPON1), chaperone protein folding (HSP90B1 and HSPD1), development and growth (CTTNNA2, SPON1, and YES1), transcriptional nuclear regulation (PARP1, SSBP1, and XRCC5), and cell signaling ...…”
Section: Resultsmentioning
confidence: 99%
“…Specific functions of the downregulated proteins are provided in Table S3. , Biological functions of downregulated proteins consist of trafficking and cell morphology (AHSG, AP2A2, COL1A2, COL4A2, DCN, FAT1, KIF5B, LLGL1, NID1, NUMA1, SEPT2, and TPM4) biochemical and binding activities (ALDOA, ANXA5, ASS1, ATP1A2, CKB, CLIC1, LOXL3, PLOD1, PSAP, PYGB, SLC9A3R1, and SPOCK1), synaptic regulation (CTTNNA2 and SPON1), chaperone protein folding (HSP90B1 and HSPD1), development and growth (CTTNNA2, SPON1, and YES1), transcriptional nuclear regulation (PARP1, SSBP1, and XRCC5), and cell signaling ...…”
Section: Resultsmentioning
confidence: 99%
“…We selected GSE48350 database, which contains microarray data from AD cases (aged 20–99 years) and age matched normal controls, from 4 brain regions: hippocampus, entorhinal cortex, superior frontal cortex, and post-central gyrus. Previous study has demonstrated that frontal cortical dysfunction contributed a significant extent to cognitive deficits and memory loss, which was considered as the late characteristic of AD [53]; meanwhile, AD has been widely considered as an early amnesic syndrome of hippocampal type, which on behalf of the most significant clinic feature for the diagnosis of AD [5456], and we believed that the data between age-matched AD patients and normal controls were more convictive. Besides, entorhinal cortex is also considered as a vital brain region in characterizing AD, and aberrant changes of entorhinal cortex happen before hippocampus in the pathological mechanism of AD [5759].…”
Section: Discussionmentioning
confidence: 99%