Infectious Disease Clinics of North America volume 18, issue 4, P963-974 2004 DOI: 10.1016/j.idc.2004.07.010 View full text
Joseph F. Plouffe, Daniel R. Martin

Abstract: Pneumonia caused by Streptococcus pneumoniae is the most deadly form of community-acquired pneumonia. The death rate of bacteremic pneumococcal pneumonia has remained constant over the past 50 years. Several retrospective reviews of bacteremic pneumococcal pneumonia suggest that dual therapy with a beta-lactam and a macrolide antimicrobial agent is associated with a lower case fatality rate than therapy with a beta-lactam alone. These studies are reviewed, potential mechanisms are suggested, and future studies…

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