RBM38 in cancer: role and mechanism

Zou, Cheng; Wan, Ying; He, Lingjing; Zheng, Jin; Yang, Mei; Shi, Junfeng; Zhang, Min; Dong, Zhiqiang; Zhang, Dingxiao

doi:10.1007/s00018-020-03593-w

Cited by 16 publications

(13 citation statements)

References 67 publications

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“…We confirmed sex‐specific expression in XY GCs for three of them ( Supt6, Tbrg4, and Rbm38 ) by in situ hybridization. The RNA‐binding protein RBM38 (also called RNPC1) plays a tumor‐suppressive role in multiple human cancer types 80 . This protein has also been associated with the suppression of cell proliferation in multiple contexts and promotes the stability of CDKN1A 81 .…”

Section: Discussionmentioning

confidence: 99%

“…The RNA-binding protein RBM38 (also called RNPC1) plays a tumor-suppressive role in multiple human cancer types. 80 This protein has also been associated with the suppression of cell proliferation in multiple contexts and promotes the stability of CDKN1A. 81 It could therefore be involved in the mitotic arrest of XY GCs.…”

Section: Messenger Rna Processing and Intron Retention As Post-tranmentioning

confidence: 99%

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Single‐cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Section: Messenger Rna Processing and Intron Retention As Post-tranmentioning

confidence: 99%

Single‐cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination

et al. 2021

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“…Transcription factors are an important class of nuclear proteins related to the regulation of gene expression (Zou et al, 2020). Transcription factors are divided into two functional categories: basic transcription factors and regulatory transcription factors.…”

Section: Discussionmentioning

confidence: 99%

Identification of receptors for eight endocrine disrupting chemicals and their underlying mechanisms using zebrafish as a model organism

Huang

Lin

et al. 2020

Ecotoxicology and Environmental Safety

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Herein, eight common endocrine disrupting chemicals (EDCs) were exposed to zebrafish (Danio rerio) to investigate the relationship between different EDCs and their activated estrogen receptors. Under acute exposure, we identified five major malformation types whose incidence and deformity modes differed among EDCs. Luciferase analysis divided the EDC receptors into four categories: (i) triclosan (TCS), 17ß-estradiol (E2) and estriol (E3) mainly activated GPER expression; (ii) bisphenol A (BPA), p-(tert-octyl) phenol (POP), 17α-ethynylestradiol (EE2), E2 and E3 activated ERβ expression; (iii) E2 and E3 acted on both GPER and ERβ; and (iv) estrone (E1) and 9,9-bis(4-hydroxyphenyl)fluorene (BHPF) had little effect on the two receptors. In vivo immunofluorescence experiments on 96-hpf larvae provided evidence that TCS and POP acted on GPER and ERβ, respectively, while E2 acted on the two receptors simultaneously. Luciferase activities in the promoter regions of gper (À 986 to À 488) and erβ (À 1998 to À 1496) were higher than those in other regions, identifying these key regions as targets for transcription activity. TCS promoted GPER expression by acting on the JUND transcription factor, while POP promoted ERβ expression by activating the Foxl1 transcription factor. In contrast, E2 mainly regulated transcription of GPER and ERβ by Arid3a. These findings provide compelling evidence that different EDCs possess varying estrogen receptors, leading to differential regulatory pathways and abnormality symptoms. These results offer an experimental strategy and fundamental information to assess the molecular mechanisms of EDC-induced estrogen effects.

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“…Loss of RBM38 decreases tumor penetrance when p53 is present [ 79 ], but this promotes tumor progression by reducing the expression of tumor suppressor genes when p53 is absent [ 80 ]. Thus, RBM38 can also function as a tumor repressor or as an oncogene, depending on the cancer types [ 17 , 81 ]. Indeed, RBM38 regulates similar targets as RBM24, and RBM38-deficient mice are also prone to spontaneous tumors [ 79 ].…”

Section: Discussionmentioning

confidence: 99%

RBM24 in the Post-Transcriptional Regulation of Cancer Progression: Anti-Tumor or Pro-Tumor Activity?

Shi

2022

Cancers

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RNA-binding proteins are critical post-transcriptional regulators of gene expression. They are implicated in a wide range of physiological and pathological processes by modulating nearly every aspect of RNA metabolisms. Alterations in their expression and function disrupt tissue homeostasis and lead to the occurrence of various cancers. RBM24 is a highly conserved protein that binds to a large spectrum of target mRNAs and regulates many post-transcriptional events ranging from pre-mRNA splicing to mRNA stability, polyadenylation and translation. Studies using different animal models indicate that it plays an essential role in promoting cellular differentiation during organogenesis and tissue regeneration. Evidence is also accumulating that its dysregulation frequently occurs across human cancers. In several tissues, RBM24 clearly functions as a tumor suppressor, which is consistent with its inhibitory potential on cell proliferation. However, upregulation of RBM24 in other cancers appears to promote tumor growth. There is a possibility that RBM24 displays both anti-tumor and pro-tumor activities, which may be regulated in part through differential interactions with its protein partners and by its post-translational modifications. This makes it a potential biomarker for diagnosis and prognosis, as well as a therapeutic target for cancer treatment. The challenge remains to determine the post-transcriptional mechanisms by which RBM24 modulates gene expression and tumor progression in a context- or background-dependent manner. This review discusses recent findings on the potential function of RBM24 in tumorigenesis and provides future directions for better understanding its regulatory role in cancer cells.

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RBM38 in cancer: role and mechanism

Cited by 16 publications

References 67 publications

Single‐cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination

Single‐cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination

Identification of receptors for eight endocrine disrupting chemicals and their underlying mechanisms using zebrafish as a model organism

RBM24 in the Post-Transcriptional Regulation of Cancer Progression: Anti-Tumor or Pro-Tumor Activity?

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