Rats with lesions in anteromedial extrastriate cortex fail to learn a visuosomatic conditional response

Pinto-Hamuy, Teresa; Olavarría, Jaime F.; Guic-Robles, Eliana; Morgues, Mónica; Nassal, Omar; Petit, Daniel

doi:10.1016/0166-4328(87)90070-2

Cited by 30 publications

(12 citation statements)

References 47 publications

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“…This input may by important for aligning external visual and auditory coordinates, with body-centered somatosensory, proprioceptive and vestibular maps required for path integration and transformation of the self-location into goal-directed behavior (Chen et al, 1994; Whitlock et al, 2008). Unsurprisingly, disruption of visual and somatosensory integration in rat posterior parietal cortex interferes with path integration and results in disorientation (Pinto-Hamuy et al, 1987; Save and Poucet, 2000). …”

Section: Discussionmentioning

confidence: 99%

Gateways of Ventral and Dorsal Streams in Mouse Visual Cortex

Wang

Gao

Burkhalter³

2011

J. Neurosci.

212

244

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Section: Discussionmentioning

confidence: 99%

Gateways of Ventral and Dorsal Streams in Mouse Visual Cortex

Wang

Gao

Burkhalter³

2011

J. Neurosci.

212

244

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“…There are several reasons to consider this cortical region, the posterior parietal/anteromedial cortex, as a multimodal association cortex quite comparable in location, functions and connections to the parietal association cortex of primates (Chen et al, 1994a;Kolb et al, 1994). Pioneering work led by Pinto-Hamuy (Pinto-Hamuy et al, 1987) first demonstrated the multimodal association nature of the posterior parietal/anteromedial cortex in rats, using a behavioral approach. Dr. Pinto-Hamuy engaged a number of colleagues with skills complementary to hers to understand the role of parietal and occipital cortical areas in solving different spatial tasks (Sanchez et al, 1997;Espinoza et al, 1999;Pinto-Hamuy et al, 2004;Espina-Marchant et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

The parietal association cortex of the rat

Torrealba

Valdés²

2008

Biol. Res.

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Spatial cognition is a complex higher function in mammals and is involved in a variety of tasks that can be explored in the laboratory. In this review we will discuss the role of the posterior parietal/anteromedial cortex of rodents, also known as the parietal association cortex, and the hippocampal formation in spatial navigation. We will also discuss other higher associational functions of the posterior parietal/anteromedial cortex as they relate to Dr. Pinto-Hamuy's contribution to understanding behavioral functions.

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“…In that study, rats with an ibotenate lesion into the AM/PPC failed the test, suggesting that the AM/PPC area is involved in the integration of visual and somatic stimuli [23]. The lesioned rats also failed in learning a visuospatial discrimination task assessed in a Skinner box [27].…”

Section: Introductionmentioning

confidence: 99%

“…Pinto et al [23] investigated the role of the anteromedial/posterior parietal cortex (AM/ PPC) in bimodal visuo-spatial discrimination, training rats in a modified Sutherland apparatus, with a gradual procedure (fading), consisting in a retractable jumping platform and a tunnel lined with two different roughness papers, associated with either a white or a black landing door. In that study, rats with an ibotenate lesion into the AM/PPC failed the test, suggesting that the AM/PPC area is involved in the integration of visual and somatic stimuli [23].…”

Section: Introductionmentioning

confidence: 99%

Spatial cognition and memory: a reversible lesion with lidocaine into the anteromedial/posterior parietal cortex (AM/PPC) affects differently working and long-term memory on two foraging tasks

et al. 2006

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Place memory is relevant for exploration and forage behaviour. When food supply is dispersed, a win-shift has advantage over a win-stay strategy. In the Olton Octagonal Maze, the rat follows a win-shift strategy using working memory. However, in the Olton 4x4 version, the rat follows a win-stay strategy, using both working and long-term memories. It has been suggested that the neocortex is required for the resolution of tasks demanding long-term, but not for that demanding working memory alone. The role of anteromedial/posterior parietal cortex (AM/PPC) was investigated here, using a reversible lesion induced by intracerebral lidocaine infusion. Long-Evans rats were implanted with guide cannulae into the AM/PPC and trained in an Olton 4x4 maze, counting working and long-term memory errors after a delay. Then, the animals were infused with lidocaine or saline during the delay phase and tested for three days. Another series of animals, treated as before, was tested in an Olton Octagonal Maze and subjected to the same injection schedule. In the Olton 4x4 Maze, lidocaine produced a significant increase in working and long-term memory errors, compared to saline and post-lidocaine conditions. In contrast, in the Olton Octagonal Maze, lidocaine did not induce any effect on working memory errors. Thus, AM/PPC is required when both working with previous information and long-term memories are needed, but not when only working memory is required, as it happens under ethological conditions. Whenever food supply is dispersed, a win-shift strategy is preferable.

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Rats with lesions in anteromedial extrastriate cortex fail to learn a visuosomatic conditional response

Cited by 30 publications

References 47 publications

Gateways of Ventral and Dorsal Streams in Mouse Visual Cortex

Gateways of Ventral and Dorsal Streams in Mouse Visual Cortex

The parietal association cortex of the rat

Spatial cognition and memory: a reversible lesion with lidocaine into the anteromedial/posterior parietal cortex (AM/PPC) affects differently working and long-term memory on two foraging tasks

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