Rational design of a thermalresponsive-polymer-switchable FRET system for enhancing the temperature sensitivity of upconversion nanophosphors

Xiao, Qingbo; Li, Yanfang; Li, Fujin; Zhang, Mengxin; Zhang, Zhijun; Lin, Hongzhen

doi:10.1039/c4nr02497d

Cited by 40 publications

(28 citation statements)

References 52 publications

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“…In this section, we discuss illustrative examples of complex thermometric systems comprising multiple core@shell nanostructures, polymer‐ and hybrid‐based materials, and heater‐thermometer nanoplatforms …”

Section: Luminescent Thermometers Based On Ln3+ Ionsmentioning

confidence: 99%

Lanthanide‐Based Thermometers: At the Cutting‐Edge of Luminescence Thermometry

Brites

Balabhadra

Carlos

2018

Advanced Optical Materials

739

679

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Present technological demands in disparate areas, such as microfluidics and nanofluidics, microelectronics and nanoelectronics, photonics and biomedicine, among others, have reached to a development such that conventional contact thermal probes are not accomplished anymore to perform accurate measurements with submicrometric spatial resolution. The development of novel noncontact thermal probes is, then, mandatory, contributing to an expansionary epoch of luminescence thermometry. Luminescence thermometry based on trivalent lanthanide ions has become very popular since 2010 due to the unique versatility, stability, and narrow emission band profiles of the ions that cover the entire electromagnetic spectrum with relatively high emission quantum yields. Here, a perspective overview on the field is given from the beginnings in the 1950s until the most recent cutting‐edge examples. The current movement toward usage of the technique as a new tool for thermal imaging, early tumor detection, and as a tool for unveiling the properties of the thermometers themselves or of their local neighborhoods is also summarized.

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Section: Luminescent Thermometers Based On Ln3+ Ionsmentioning

confidence: 99%

Lanthanide‐Based Thermometers: At the Cutting‐Edge of Luminescence Thermometry

Brites

Balabhadra

Carlos

2018

Advanced Optical Materials

739

679

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“…Optical T measurements utilizing T ‐dependent fluorometric parameters, such as luminescence intensity (or intensity ratios) and lifetime, have been achieved with different classes of molecular and nanoscale emitters . Examples are polymer‐based nanoparticles, lanthanide‐based nanocrystals, and DNA‐based systems, such as molecular beacons (MBs)…”

Section: Figurementioning

confidence: 99%

“…Except for some nanocrystalline lanthanide‐based emitters, such as upconversion nanoparticles, which suffer from a low brightness, a different excitation power density dependence of the red and green emission, and luminescence quenching by water molecules, these requirements are very challenging to achieve . Up to date, molecular thermometers with T ‐dependent dual NIR emission have not yet been reported …”

Section: Figurementioning

confidence: 99%

Thermo‐Chromium: A Contactless Optical Molecular Thermometer

Otto

Scholz

Behnke

et al. 2017

Chemistry A European J

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The unparallelede xcited-state potential-energy landscape of the chromium(III)-based dye [1] 3 + + ([Cr(ddpd) 2 ] 3 + ;d dpd = N,N'-dimethyl-N,N'-dipyridin-2-ylpyridin-2,6-diamine) enables as trong dual emission in the near infrared region. The temperature dependence of this dual emission allows the use of [1] 3 + + as an unprecedented molecular ratiometric thermometer in the 210-373 Kt emperature range in organic and in aqueous media. Incorporation of [1] 3 + + in biocompatiblen anocarriers, such as 100 nm-sized polystyrene nanoparticles and solutol micelles, providesn anodimensional thermometers operating under physiological conditions. Optical sensing of physicochemical quantities, such as temperature (T), pressure, oxygen concentration, or pH, is of tremendous importance in many fields.[1] Applications requiring T sensing range from biology( e.g.,i ntracellular thermometry) [2] and medicald iagnostics (e.g.,p oint-of-care diagnostics [3] using amplifyinge nzymatic reactions) [4] to chemical synthesis (e.g., microfluidics [5] ), and materials sciences (e.g., T-sensitive paints [6] for spatial sensing in wind tunnels). Optical T measurements utilizing T-dependentf luorometric parameters, such as luminescence intensity (or intensity ratios) and lifetime, have been achieved with different classes of molecular and nanoscale emitters. [1c, d] Examples are polymerbased nanoparticles, [7] lanthanide-based nanocrystals, [8] and DNA-based systems, such as molecular beacons (MBs). [9] Fluorometric T sensing can be done nonratiometrically,e xploiting the T sensitivity of the fluorescencei ntensity of as ingle-emissionb and (e.g.,r hodamine B), [10] which is prone to artefacts due to fluctuationsi n, for example, excitation light intensity,o rr atiometrically requiring two emission bands, one being T sensitive and one not responding to changes in T for signal referencing.R atiometric T sensing can be achieved with three design concepts:a )a combination of two emissive dyes (T-responsive probe and T-inert reference);b )acombination of two dyes whichi nteract by ad istance-dependent process, such as fluorescencer esonance energy transfer (EnT) in systems, in which dye distance is modified by T;a nd c) as ingle dye displaying dual emission (Figure 1).[1] Scenario a) is commonly achievedb ycombining two organic fluorophores in af ixed ratio, fore xample, within nanoparticles ( Figure 1a). Both dyesm ust be excitable at the same wavelength and shows pectrally distinguishable emission bands to allow separating andi ntegrating the luminescence signals for the calculation of the excitation light intensity-independent Tsensitivequotient I probe /I ref .Fluorescent T sensors, which exploit T-dependent structural features communicated as changes in fluorescencei ntensity of the reporter dyes are fluorophore-labeled MBs ( Figure 1b). [9] These flexible single-stranded oligonucleotides are either dually labeled att heir 5'-a nd 3'-ends with af luorophore and an onemissive quencher( nonratiometric M...

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“…Apart from the drug release, it is interesting that PNIPAm was used as a spacer to link UCNP and Au nanoparticles. The distance between UCNP and Au can be adjusted by altering the temperature due to the swelling or shrinking of PNIPAm, accompanied with the change of UC emission via FRET process …”

Section: Applicationsmentioning

confidence: 99%

Synthesis and Application of Nanohybrids Based on Upconverting Nanoparticles and Polymers

Cheng

Lin

2015

Macromol. Rapid Commun.

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Lanthanide-doped upconversion nanoparticles (UCNPs) have been an emerging and exciting research field in recent years due to their unique luminescent properties of converting near-infrared light to shorter wavelength radiation. UCNPs offer excellent prospects in luminescent labeling, displays, bioimaging, bioassays, drug delivery, sensors, and anticounterfeiting applications. Along with the abundant studies and rapid progress in this area, UCNPs are promising to be a new class of luminescent probe owing to their special advantages over the conventional organic dyes and quantum dots. Among them, polymers play an important role to improve properties or endow new function of UCNPs such as for matrix materials, water solubility, linking active targeting molecules, biocompatibility, and stimuli-responsive behavior. This article briefly reviews the compositions, optical mechanisms, architectures of upconversion nanocrystals and highlights the works on various functional UCNPs/polymer nanohybrids as well as many new interesting fruits in applications.

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Rational design of a thermalresponsive-polymer-switchable FRET system for enhancing the temperature sensitivity of upconversion nanophosphors

Cited by 40 publications

References 52 publications

Lanthanide‐Based Thermometers: At the Cutting‐Edge of Luminescence Thermometry

Lanthanide‐Based Thermometers: At the Cutting‐Edge of Luminescence Thermometry

Thermo‐Chromium: A Contactless Optical Molecular Thermometer

Synthesis and Application of Nanohybrids Based on Upconverting Nanoparticles and Polymers

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