Ratiometric photoacoustic imaging of endoplasmic reticulum polarity in injured liver tissues of diabetic mice

Xiao, Haibin; Wu, Chuanchen; Li, Ping; Gao, Wen; Zhang, Wen; Tong, Lili; Tang, Bo

doi:10.1039/c7sc02330h

Cited by 115 publications

(77 citation statements)

References 57 publications

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“…Fatty acids in the liver induce free radical formation, causing lipid peroxidation and inducing release of proinflammatory cytokines. The release of malondialdehyde and 4-hydroxynonenal correspondingly causes cell death, protein cross-linkage, and stellate cells activation, leading to collagen synthesis and fibrosis (Xiao et al, 2017). Oxidative stress is also a critical factor in the progression of nonalcoholic fatty liver disease associated with diabetes (Mohamed et al, 2016).…”

Section: Fgf1 Treatment Blocked Diabetes-induced Oxidative Stress In mentioning

confidence: 99%

Fibroblast Growth Factor 1 Ameliorates Diabetes-Induced Liver Injury by Reducing Cellular Stress and Restoring Autophagy

Wang

et al. 2020

Front. Pharmacol.

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Background: Type 2 diabetes (T2D) is a metabolic dysfunction disease that causes several complications. Liver injury is one of these that severely affects patients with diabetes. Fibroblast growth factor 1 (FGF1) has glucose-lowering activity and plays a role in modulation of several liver injuries. Nevertheless, the effects and potential mechanisms of FGF1 against diabetes-induced liver injury are unknown. Methods: To further investigate the effect of FGF1 on diabetic liver injury, we divided db/ db mice into two groups and intraperitoneally (i.p.) injected either with FGF1 at 0.5 mg/kg body weight or saline every other day for 4 weeks. Then body weights were measured. Serum and liver tissues were collected for biochemical and molecular analyses. Results: FGF1 significantly reduced blood glucose and ameliorated diabetes-induced liver steatosis, fibrosis, and apoptosis. FGF1 also restored defective hepatic autophagy in db/db mice. Mechanistic investigations showed that diabetes markedly induced oxidative stress and endoplasmic reticulum stress and that FGF1 treatment significantly attenuated these effects. Conclusions: FGF1-associated glucose level reduction and amelioration of cellular stress are potential protective effects of FGF1 against diabetes-induced liver injury.

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Section: Fgf1 Treatment Blocked Diabetes-induced Oxidative Stress In mentioning

confidence: 99%

Fibroblast Growth Factor 1 Ameliorates Diabetes-Induced Liver Injury by Reducing Cellular Stress and Restoring Autophagy

Wang

et al. 2020

Front. Pharmacol.

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“…For example, Tang and co‐workers designed an endoplasmic reticulum probe (ER‐P) with a tertiary amine and difluoroboronate moiety. ER‐P was sensitive to the environmental polarity . As shown in Figure a, the maximum absorption of ER‐P went from approximately 694 nm in toluene (dielectric constant ε = 2.37, polarity index P = 2.3) to 794 nm in dimethyl sulfoxide (DMSO, ε = 2.37, polarity index P = 7.2).…”

Section: Applications Of Photoacoustic Detectionmentioning

confidence: 99%

“…Moreover, they also combined fluorescence imaging with PAI to obtain an enhanced sensitive and selective polarity detection. This study provided a new approach for the early diagnosis and therapeutic evaluation of diabetes‐induced liver injury (Figure c) …”

Section: Applications Of Photoacoustic Detectionmentioning

confidence: 99%

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Photoacoustic Probes for Molecular Detection: Recent Advances and Perspectives

Zeng

Lin

et al. 2018

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Photoacoustic (PA) imaging (PAI) is a noninvasive and nonionizing biomedical imaging modality that combines the advantages of optical imaging and ultrasound imaging. Based on PAI, photoacoustic detection (PAD) is an emerging approach that is involved with the interaction between PA probes and analytes resulting in the changes of photoacoustic signals for molecular detection with rich contrast, high resolution, and deep tissue penetration. This Review focuses on the recent development of PA probes in PAD. The following contents will be discussed in detail: 1) the construction of PA probes; 2) the applications and mechanisms of PAD to different types of analytes, including microenvironments, small biomolecules, or metal ions; 3) the challenges and perspectives of PA probes in PAD.

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“…[5][6][7] The pathological activity of the cell changes with its polarity, and abnormal polarity is related to diabetes, neurological diseases, and cancer. [8][9][10][11] Therefore, detecting cellular polarity is important in research on pathological and biological phenomena.…”

Section: Introductionmentioning

confidence: 99%

Combining hydrophilic and hydrophobic environment sensitive dyes to detect a wide range of cellular polarity

Park

Juvekar

et al. 2020

Chem. Sci.

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Ratiometric photoacoustic imaging of endoplasmic reticulum polarity in injured liver tissues of diabetic mice

Abstract: We have developed a new fluorescent and photoacoustic dual-mode probe, ER-P, for the detection of ER polarity of liver tissues in normal and diabetic mice.

Cited by 115 publications

References 57 publications

Fibroblast Growth Factor 1 Ameliorates Diabetes-Induced Liver Injury by Reducing Cellular Stress and Restoring Autophagy

Fibroblast Growth Factor 1 Ameliorates Diabetes-Induced Liver Injury by Reducing Cellular Stress and Restoring Autophagy

Photoacoustic Probes for Molecular Detection: Recent Advances and Perspectives

Combining hydrophilic and hydrophobic environment sensitive dyes to detect a wide range of cellular polarity

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