Rates of Biological Aging and Its Relationship to Neuropsychological Peculiarities in Patients With Occupational Neurointoxications

Abstract

This paper presents a quantitative assessment of the aging process in the occupational neurotoxicosis. Acceleration rate of biological aging has been demonstrated in trained workers of a chemical factory exposed to vinylchloride, metallic mercury vapor in patients with newly proven diagnosis - chronic elemental mercury intoxication and chronic elemental mercury intoxication in the long-term period in 1.9; 2.8; 7.2; 7.5 times compared to the rate of a control group. Six-time increase in the proportion of patients with acceleration rate of aging compared to the norm (70 % vs. 12 %) has been found out among fireman-liquidators. To study the interdependence of indicators characterizing the state of cognitive sphere and the rate of biological aging in patients with occupational neurointoxication a correlation analysis of the data of neuropsychological and clinical and physiological studies has been carried out. Raising of biological age and acceleration rate of biological aging in patients with neurointoxications are accompanied by disorders of categoric, conceptual, analytical - synthetical thinking, audio-verbal (short-term) and the visual image memory, spatial and dynamic praxis, objective gnosis, impressive and expressive speech, caused by deficiency of functioning of the frontal, parietal-temporal, parietal-occipital lobes, premotor and parietal regions of the left brain, overlap zone (tertiary temporo-parietal-occipital cortex).

Risks related to cognitive disorders development in workers with different work experience employed at an oil extracting facility

“…Effects produced by neurotoxicants on the nervous system become apparent via diffuse damage to the brain that is accompanied with occurring brainstem-hypothalamic syndrome, and syndrome related to cerebral and psychoneurological disorders 2 . Impacts exerted by adverse occupational factors (chemical factors, noise, vibration, and labor intensity) on cognitive functions have been examined by many authors [11,[17][18][19]. As per data obtained by M. Reale et al, 80 examined workers employed in oil extraction had increased anxiety levels and occupational stress signs [20].…”