Rate of True-Positive Findings of COVID-19 Typical Appearance at                     Chest CT per RSNA Consensus Guidelines in an Increasingly Vaccinated                     Population

Polyakov, Nicole J.; Som, Avik; Mercaldo, Nathaniel D.; Capua, John Di; Little, Brent P.; Flores, Efrén J.

doi:10.1148/radiol.220680

Cited by 7 publications

(7 citation statements)

References 24 publications

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“…[The authors] show lower proportions of “typical” appearances in those infected with an Omicron variant, concordant with recent work showing that the diagnostic accuracy of RSNA guidelines for COVID-19 reporting has fallen significantly with the rise of vaccination and viral mutation ( 5 ). As the authors point out, this is likely at least in part due to the presence of infections other than SARS-CoV-2, either as the primary driver of imaging severity and appearance, or as an important co-infection.…”

supporting

confidence: 82%

Variants and Vaccination of COVID-19: New Complexities for Chest Imaging Research and Clinical Practice

Little

2023

Radiology

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supporting

confidence: 82%

Variants and Vaccination of COVID-19: New Complexities for Chest Imaging Research and Clinical Practice

Little

2023

Radiology

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“…Ground-glass opacities appear in the first few days, followed by mixed consolidation and ground-glass opacity ( 8 ). Vaccination and SARS-CoV-2 variants can modulate this appearance ( 9 ) ( 10 ) ( 11 ). Other features that can be seen in OP, including perilobular and bandlike opacities, are also frequently reported ( 12 ) ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Chronic Pulmonary Manifestations of COVID-19 Infection: Imaging Evaluation

Murphy

Little

2023

Radiology

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“…Fortunately, the incidence of influenza was historically low when COVID-19 predominated [ 71 ], and organizing pneumonia is an uncommon disease. Furthermore, vaccination [ 72 ] and the Omicron variant [ 73 – 75 ] can decrease diagnostic performance based on typical CT findings. Accordingly, the current pooled estimates are applicable to the early phase of the COVID-19 pandemic when vaccination was not sufficiently available and before the Omicron variant occurred.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic performance of standardized typical CT findings for COVID-19: a systematic review and meta-analysis

2023

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Objective To meta-analyze diagnostic performance measures of standardized typical CT findings for COVID-19 and examine these measures by region and national income. Methods MEDLINE and Embase were searched from January 2020 to April 2022 for diagnostic studies using the Radiological Society of North America (RSNA) classification or the COVID-19 Reporting and Data System (CO-RADS) for COVID-19. Patient and study characteristics were extracted. We pooled the diagnostic performance of typical CT findings in the RSNA and CO-RADS systems and interobserver agreement. Meta-regression was performed to examine the effect of potential explanatory factors on the diagnostic performance of the typical CT findings. Results We included 42 diagnostic performance studies with 6777 PCR-positive and 9955 PCR-negative patients from 18 developing and 24 developed countries covering the Americas, Europe, Asia, and Africa. The pooled sensitivity was 70% (95% confidence interval [CI]: 65%, 74%; I2 = 92%), and the pooled specificity was 90% (95% CI 86%, 93%; I2 = 94%) for the typical CT findings of COVID-19. The sensitivity and specificity of the typical CT findings did not differ significantly by national income and the region of the study (p > 0.1, respectively). The pooled interobserver agreement from 19 studies was 0.72 (95% CI 0.63, 0.81; I2 = 99%) for the typical CT findings and 0.67 (95% CI 0.61, 0.74; I2 = 99%) for the overall CT classifications. Conclusion The standardized typical CT findings for COVID-19 provided moderate sensitivity and high specificity globally, regardless of region and national income, and were highly reproducible between radiologists. Critical relevance statement Standardized typical CT findings for COVID-19 provided a reproducible high diagnostic accuracy globally. Key points Standardized typical CT findings for COVID-19 provide high sensitivity and specificity. Typical CT findings show high diagnosability regardless of region or income. The interobserver agreement for typical findings of COVID-19 is substantial. Graphical abstract

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Rate of True-Positive Findings of COVID-19 Typical Appearance at Chest CT per RSNA Consensus Guidelines in an Increasingly Vaccinated Population

Cited by 7 publications

References 24 publications

Variants and Vaccination of COVID-19: New Complexities for Chest Imaging Research and Clinical Practice

Variants and Vaccination of COVID-19: New Complexities for Chest Imaging Research and Clinical Practice

Chronic Pulmonary Manifestations of COVID-19 Infection: Imaging Evaluation

Diagnostic performance of standardized typical CT findings for COVID-19: a systematic review and meta-analysis

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