Rate of Growth in Melanomas

Liu, Wendy; Dowling, John P.; Murray, William K.; McArthur, Grant A.; Thompson, John F.; Wolfe, Rory; Kelly, John W.

doi:10.1001/archderm.142.12.1551

Cited by 299 publications

(98 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, evidence has been provided that MM comprises a family of different tumours that vary biologically in growth activity [24,25,26]. Rapidly growing MMs, whose characteristics and associations were described by Liu et al [24], were more often symmetrical, elevated, amelanotic, symptomatic and with regular borders.…”

Section: Discussionmentioning

confidence: 99%

Variegated Dermoscopy of in situ Melanoma

Seidenari

Bassoli²,

Borsari³

et al. 2012

Dermatology

View full text Add to dashboard Cite

Background: Melanomas in situ (MIS) are difficult to diagnose, lacking well-established dermoscopic descriptors. Objective: The aim of this study was toimprove the identification of early melanomas describing the variegated dermoscopic features of MIS and their correlation with demographic and clinical aspects. Methods: Dermoscopic images of 114 histologically proven MIS were evaluated by 3 expert dermoscopists and classified into their main dermoscopic patterns. Dermoscopic features were also considered for their correlation with clinical parameters. Results: Eight different dermoscopic subtypes of MIS were identified: reticular grey-blue (27.2%), reticular (21.1%), multicomponent (20.2%), island (10.5%), spitzoid (7%), inverse network (6.1%), ‘net-blue globules’ (5.3%) and globular (2.6%). Clinical characteristics of lesions and patients varied according to the different dermoscopic groups. Conclusion: We hypothesize that the different dermoscopic subgroups of MIS correspond to lesions with a different origin and, possibly, various patterns of growth and a different biological behaviour.

show abstract

Section: Discussionmentioning

confidence: 99%

Variegated Dermoscopy of in situ Melanoma

Seidenari

Bassoli²,

Borsari³

et al. 2012

Dermatology

View full text Add to dashboard Cite

show abstract

“…This is because a delayed treatment of even only a few weeks in the case of nodular melanoma may result in a significant increase in tumor volume and invasion level [20]. Thus the correct diagnosis and adequate management of red nodules requires a high level of clinical skill.…”

Section: Discussionmentioning

confidence: 99%

Reflectance Confocal Microscopy for the Evaluation of Solitary Red Nodules

et al. 2012

View full text Add to dashboard Cite

The correct assessment of a solitary red nodule in clinical practice is of crucial importance, amelanotic melanoma being the most important differential diagnosis. Dermoscopy is nowadays a pivotal tool in the management of skin tumors, however it has some limitations in the evaluation of nonpigmented lesions, in which the diagnosis is merely based on the evaluation of the vascular pattern. Recently, reflectance confocal microscopy has been introduced as a new, noninvasive technique for the diagnosis of skin lesions. Confocal microscopy provides skin imaging in vivo at cellular level resolution, close to conventional histology. We present a series of clinical scenarios of red nodules, including melanoma metastasis, pyogenic granuloma, eccrine poroma, Spitz nevus and dermatofibroma. Reflectance confocal microscopy examination added important information to the clinical diagnosis and subsequent management in all cases except for dermatofibroma. We discuss the advantages and limitations of this technique in this particular field of application.

show abstract

“…Twenty-five years later we have overwhelming evidence for the genetic heterogeneity of the entity we call cutaneous melanoma. [72][73][74] Several pathways may result in melanoma development, and understanding this heterogeneity may allow us to improve on our treatment of advanced disease. In this regard, the changing epidemiology of melanoma over the last decades seen in data from certain countries raises several questions.…”

Section: Epidemiology Diagnosis Screening and Prognosismentioning

confidence: 99%