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Cited by 55 publications
(50 citation statements)
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References 23 publications
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“…To confirm the complete inactivation of V1 gene in our knockout (KO) mice, we immunized them with EPC-KLH and detected anti-PC-secreting B cells in the spleen by ELISPOT and anti-PC Abs in the serum by ELISA. V H 1-id ϩ Abs were assessed by using the rat anti-mouse V H 1 Ab T68.3, which recognizes all Abs carrying a V1 H chain (33). Homozygous knockout mice produced neither V H 1-id ϩ anti-PC Ab-secreting B cells (Table 1) nor V H 1-id ϩ anti-PC Abs (Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…To confirm the complete inactivation of V1 gene in our knockout (KO) mice, we immunized them with EPC-KLH and detected anti-PC-secreting B cells in the spleen by ELISPOT and anti-PC Abs in the serum by ELISA. V H 1-id ϩ Abs were assessed by using the rat anti-mouse V H 1 Ab T68.3, which recognizes all Abs carrying a V1 H chain (33). Homozygous knockout mice produced neither V H 1-id ϩ anti-PC Ab-secreting B cells (Table 1) nor V H 1-id ϩ anti-PC Abs (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…The 3Ј probe is a 414-bp fragment obtained by PCR on the BamHI͞NotI subclone with the primers 5Ј-CATCACAC ATAACACCTA-3Ј and 5Ј-ATCAGGATCAGCCACTCT-3Ј. (33). The biotinylated goat anti-mouse IgG and IgM and streptavidin alkaline phosphatase were obtained from American Type Culture Collection, Fisher Biotech, and Calbiochem, respectively.…”
Section: Construction Of the V1 Targeting Vector And Generation Of Mumentioning
confidence: 99%
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“…To examine the impact of the U10 mutation on V region structure, we examined the reactivity of a number of antiidiotypic antibodies with the S107 and U10 antibodies. Although eight different anti-T15 monoclonal antibodies, specific for nonbinding site surfaces ofthe V domain (29), did not distinguish between the U10 and S107 proteins, polyclonal antibodies to the antigen-binding site of S107 did (Fig. 4).…”
Section: Resultsmentioning
confidence: 99%
“…Hence, the structural characteristics and/or combinatorial diversity of certain V H genes is sufficient to generate antibodies that protect against ST8. Human PPS3-binding MAbs generated from human immunoglobulin transgenic mice also (18,19). There is ample evidence that PPS-binding MAbs can prolong the survival of mice that are infected with the homologous ST (9, 10, 14, 43, 52).…”
Section: Discussionmentioning
confidence: 99%