2005
DOI: 10.1590/s0100-72032005000400010
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Rastreamento e diagnóstico das neoplasias de ovário: papel dos marcadores tumorais

Abstract: 222Rev Bras Ginecol Obstet. 2005; 27(4): 222-7 Revisão RESUMO O câncer de ovário é a neoplasia ginecológica mais letal e a sobrevida global é inferior a 40% em cinco anos. Isto ocorre principalmente porque a maioria das pacientes apresenta estadios avançados no momento do diagnóstico. Nestes casos as opções terapêuticas -citorredução e quimioterapia -são apenas parcialmente efetivas. Quando diagnosticado precocemente, por outro lado, a sobrevida em cinco anos é superior a 90% e a cirurgia geralmente é o único … Show more

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Cited by 12 publications
(19 citation statements)
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“…About 70% of women diagnosed with ovarian carcinoma present tumor extension beyond the pelvis. The malignant ovarian tumors originated from the surface epithelium and/or stroma are graded as well differentiated (grade 1), moderately differentiated (grade 2) and poorly differentiated (grade 1); this classification is associated with prognostic factors and therapeutic modalities (8,12,(20)(21)(22)(23)(24) . The tumor marker CA 125 is a glycoprotein synthesized by ovarian superficial cells; its serum measurement may be employed in the evaluation of disease progression or even in the early diagnosis of ovarian tumors.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…About 70% of women diagnosed with ovarian carcinoma present tumor extension beyond the pelvis. The malignant ovarian tumors originated from the surface epithelium and/or stroma are graded as well differentiated (grade 1), moderately differentiated (grade 2) and poorly differentiated (grade 1); this classification is associated with prognostic factors and therapeutic modalities (8,12,(20)(21)(22)(23)(24) . The tumor marker CA 125 is a glycoprotein synthesized by ovarian superficial cells; its serum measurement may be employed in the evaluation of disease progression or even in the early diagnosis of ovarian tumors.…”
Section: Discussionmentioning
confidence: 99%
“…Reis et al suggest that the routine transvaginal ultrasonography and the serial measurement of CA 125 with risk assessment for ovarian carcinoma is fundamental in the distinction between benign and malignant lesions, and in the detection of lesions in early stages (20) . Montero et al cite that serum CA 125 levels are similar among benign ovarian neoplasms such as mature cystic teratoma and cystadenoma (16) .…”
Section: Discussionmentioning
confidence: 99%
“…Serum CA-125 levels can also be useful for the monitoring of patients undergoing adjuvant chemotherapy due to ovarian carcinomas, or for the early detection of tumor recurrence after initial treatment. [7][8][9][10][11][12][13][14] We wanted to analyze the demographic profile, staging, and sensitivity and specificity of CA-125 levels in a patient with ovarian cancer in an Indian scenario.…”
Section: Introductionmentioning
confidence: 99%
“…O marcador ideal deve ser produzido pela mesma linhagem e seus níveis devem ser detectáveis mesmo em pouca quantidade de células. Seus níveis devem mostrar com grande precisão o processo de regressão, presença ou evolução da doença, utilizando seus valores normais para uma possível cura (Reis, 2005).…”
Section: Introductionunclassified