Raro caso de metástasis parotídea por carcinoma renal de células claras 11 años después del diagnóstico inicial

Axillary skin metastasis of renal cell carcinoma—Case report

“…Unfortunately, the prognosis of our patient is extremely poor considering the rapid progression of the metastatic disease under tyrosine-kinase inhibitor treatment and the development of unusual metastases: axilla and lower limb muscles. At this moment, approximately 10–13% of all cases have a 5-year survival rate in metastatic renal cell carcinoma after the surgical treatment of RCC solitary metastasis [2], [5], [13]. In case of skin metastasis, the survival rates are even lower: 6–12 months [2].…”

“…The most common pathway for distant dissemination of the tumor cells is through the lymphatic vessels to the proximal lymph nodes (paracaval/paraortic/interaortocaval lymph nodes) and then ascending through the thoracic duct to the head and neck region [4], [5]. One alternative way of dissemination is the hematogenous path through the paraspinal venous plexus (Batson’s plexus) which drains the blood from the multiple arteriovenous fistulae formed during the process of neoplastic angiogenesis [2], [4], [5], [6]. These two pathways of dissemination could account for the unusual metastatic site occurrence especially in the head, neck and trunk [2], [6].…”

Mediastinal Metastasis 10 Years after Primary Renal Cell Carcinoma<br/>—A Report of a Case and a Review

“…A rare case of RCC metastasis in the parotid gland was described eleven years after the initial diagnosis [11]. Metastasis of renal cell carcinoma to the buccal mucosa occurred 19 years after radical nephrectomy [17].…”