2016
DOI: 10.1016/j.stemcr.2016.09.010
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Abstract: SummaryRecent studies have implicated keratin 5 (KRT5)+ cells in repopulation of damaged lung tissue following severe H1N1 influenza virus infection. However, the origins of the cells repopulating the injured alveolar region remain controversial. We sought to determine the cellular dynamics of lung repair following influenza infection and define whether nascent KRT5+ cells repopulating alveolar epithelium were derived from pre-existing alveolar or airway progenitor cells. We found that the wound-healing respon… Show more

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Cited by 117 publications
(112 citation statements)
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References 25 publications
(40 reference statements)
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“…There was no contribution from type 1 or type 2 cells. Furthermore, this study also demonstrated the presence of Sox2-creER lineage-labeled cells that are negative for KRT5, SCGB1A1 and FOXJ1 expression (Ray et al, 2016). This suggests the presence of some rare pre-existing Sox2 + Lin − cells that are very likely to be the same cells as the previously identified LNEPs.…”
Section: Transdifferentiation and Transdetermination Of Airway Cellssupporting
confidence: 74%
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“…There was no contribution from type 1 or type 2 cells. Furthermore, this study also demonstrated the presence of Sox2-creER lineage-labeled cells that are negative for KRT5, SCGB1A1 and FOXJ1 expression (Ray et al, 2016). This suggests the presence of some rare pre-existing Sox2 + Lin − cells that are very likely to be the same cells as the previously identified LNEPs.…”
Section: Transdifferentiation and Transdetermination Of Airway Cellssupporting
confidence: 74%
“…However, this study was also called into question due to the caveat that tamoxifen-induced labeling might have persisted into the time period in which pod cells differentiated into basal and secretory cells. Thus, instead of demonstrating that pods cells were derived from secretory or preexisting basal-like cells, it has been suggested that these authors simply labeled secretory and basal cells that had already differentiated from pod cells (Ray et al, 2016;Vaughan et al, 2015).…”
Section: Transdifferentiation and Transdetermination Of Airway Cellsmentioning
confidence: 99%
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“…In contrast to a report by Zuo and colleagues (10), but in agreement with Vaughan and Ray and colleagues (8,11), the vast majority of Krt5 1 cells were untraced by any Cre driver, indicating their derivation from lineage-negative epithelial progenitors (LNEPs). However, additional Krt5-CreERT2-traced cells were identified in heavily injured regions and they expressed markers of AEC1s but never AEC2s.…”
supporting
confidence: 81%
“…However, several studies in mice over the past few years have suggested that the regenerative capacity of these cells can be overwhelmed quickly by injury, a phenomenon especially apparent in severe influenza infection (H1N1, PR8), wherein there is a dramatic influx of alveolar epithelial cells expressing the basal cell marker Krt5 subsequent to widespread AEC2 ablation by the virus (7)(8)(9)(10)(11). This phenomenon has also been demonstrated to occur to a lesser degree after bleomycin injury (8,12).…”
mentioning
confidence: 99%