Rare presentation of inflammatory myofibroblastic tumor in the kidney

Abduljawad, Hiba; Aslan, Ahmet; Aldoseri, Khalifa; Yılmaz, Erdem; Ibrahim, Wael Hamed

doi:10.1016/j.radcr.2020.05.043

Cited by 7 publications

(11 citation statements)

References 13 publications

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“…These markers are typically positive in Mullerian duct derived (gynecologic) tumors but not in extrauterine IMTs. 54 This suggests that the cellular origin of uterine and extrauterine IMTs could be distinct.…”

Section: Discussionmentioning

confidence: 99%

Histopathologic and Molecular Characterization of Uterine Leiomyoma–like Inflammatory Myofibroblastic Tumor

Kuisma

Jokinen

Pasanen³

et al. 2022

American Journal of Surgical Pathology

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Uterine leiomyoma (UL) is a common benign neoplasm which can sometimes be difficult to differentiate from the uterine inflammatory myofibroblastic tumor (IMT) based on morphology alone. IMT is a myofibroblastic/fibroblastic neoplasm which has typically been considered to be rare in the uterus. Its clinical behavior is usually indolent although aggressive variants exist. The majority of IMTs harbor genomic rearrangement of anaplastic lymphoma kinase (ALK), while ALK fusion has not been thus far detected in ULs. We analyzed 2263 ULs of which 9 (0.4%) had tyrosine-kinase activation. Seven of the samples were ALK immunopositive: 6 had an ALK fusion gene and 1 overexpressed an ALK transcript skipping exons 2 to 3, Moreover, 1 sample had a RET, and 1 a PDGFRB fusion gene. While no recurrent somatic mutations were found, 1 patient had an ALK germline mutation. Seven tumors showed leiomyoma-like morphology, 1 tumor had slightly loose, and 1 fibrous growth pattern. Six tumors had mild to moderate lymphocyte infiltration, while no immune cell infiltration was detected in 3 cases. None of the tumors showed aggressive behavior. Except for strong ALK positivity (7/9 tumors) the protein expression profile of the tumors was identical to ULs and distinct from other mesenchymal uterine tumors. In gene expression level, these tumors and the known UL subclasses did not separate perfectly. However, vitamin C metabolism and epithelial-mesenchymal transition pathways were uniquely enriched in these lesions. The overall similarity of the analyzed tumors to UL raises the question whether an UL diagnosis would be more proper for a subset of uterine IMTs.

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Section: Discussionmentioning

confidence: 99%

Histopathologic and Molecular Characterization of Uterine Leiomyoma–like Inflammatory Myofibroblastic Tumor

Kuisma

Jokinen

Pasanen³

et al. 2022

American Journal of Surgical Pathology

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“…IMT is a rare benign condition and is thought to be an inflammatory pseudotumor rather than an actual tumoral process ( 6 , 7 ). IMT is defined histologically by the growing number of typical spindle-shaped cells and inflammatory infiltration of plasma cells, eosinophils, and lymphocytes ( 5 , 6 ).…”

Section: Discussionmentioning

confidence: 99%

“…IMT is more common in children than adults without gender preference; nonetheless, extrapulmonary forms are more common in adult females, making our patient’s age and gender less prevalent ( 9 ). Although IMT has been seen in other organs, it is extremely rare in the kidney, with only a few published cases ( 1 , 5 , 7 , 9 ).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumor of the Right Kidney Mimicking a Locally Advanced Renal Carcinoma: A Case Report

Ariafar

Ahmed

Khorshidi

et al. 2022

jkcvhl

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An inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with an unclear origin that can arise anywhere on the body. It contains spindle cells (myofibroblasts) with different inflammatory elements. Primary IMT of the kidney is a clinically rare disease and is difficult to differentiate from other renal malignancies. We reported a 49-year-old male who presented with right flank pain in the past year. A computed tomography scan showed a mixed density with slight heterogeneous enhancement mass in the upper pole of the right kidney, two small hypodense nodules invading the liver, and another mass in the lateral aspect of inferior vena cava. The patient underwent right radical nephrectomy and metastasectomy. IMT was confirmed by both postoperative histopathological examination and immunohistochemical assay. The patient recovered well after the operation, and no recurrence or metastasis was noted during the 12-month follow-up.

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“…Despite the uncertain biological behavior of IMT, most patients get a favorable prognosis after surgery. 4 Herein, we report an IMT in a 6-year-old boy that was misdiagnosed as Wilms' tumor. Written informed consent for academic use of his information was obtained from the children's parents.…”

Section: Introductionmentioning

confidence: 90%

Child inflammatory myofibroblastic tumor of the kidney misdiagnosed as Wilms’ tumor : Case report

Bai

Liu²,

Yue

et al. 2022

Preprint

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Rare presentation of inflammatory myofibroblastic tumor in the kidney

Cited by 7 publications

References 13 publications

Histopathologic and Molecular Characterization of Uterine Leiomyoma–like Inflammatory Myofibroblastic Tumor

Histopathologic and Molecular Characterization of Uterine Leiomyoma–like Inflammatory Myofibroblastic Tumor

Inflammatory Myofibroblastic Tumor of the Right Kidney Mimicking a Locally Advanced Renal Carcinoma: A Case Report

Child inflammatory myofibroblastic tumor of the kidney misdiagnosed as Wilms’ tumor : Case report

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