Rapidly Progressing Myelodysplastic Syndrome Initially Presenting as Acute Leukemia

Abstract

Myelodysplastic syndrome (MDS) refers to a group of various stem cell disorders, characterized by dysplastic and ineffective production in one or more cell lines. In general, MDS tends to present slowly over months to years and is commonly detected with routine bloodwork by primary care physicians. Patients may be asymptomatic and depending on age, comorbidities and risk classification of MDS may not require aggressive therapy. However, MDS carries the risk of progressing to acute leukemia over time. We present a case of rapidly progressive MDS in a previously healthy middle-aged female, originally presenting and treated as acute leukemia.

Phase 1/2 study evaluating the safety and efficacy of DSP‐7888 dosing emulsion in myelodysplastic syndromes

“… 1 The clinical course of MDS is extremely variable and may be indolent or rapidly progressive, with marked symptom burden and transformation into acute myeloid leukemia (AML). 2 , 3 In Japan, the estimated incidence of MDS is 3.8 cases per 100 000 for men and 2.4 cases per 100 000 for women. 4 However, incidence increases sharply with age, particularly in those aged over 70 years.…”