Rapidly Growing Mycobacteria

Han, Xiang Y.; Dé, Indra; Jacobson, Kalen

doi:10.1309/1kb2gkyt1bueylb5

Cited by 132 publications

(48 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…M. abscessus was found in 65% of pulmonary RGM disease, and the ratio of patients who met the diagnostic criteria to patients from whom RGM was isolated was highest in those patients with M. abscessus. This result also coincided with the results of previous reports in which M. abscessus was found to be the most virulent pathogen in pulmonary RGM disease [5,8,11,19]. The patients in the present study were lean, aged and did not show any sex bias.…”

Section: Discussionsupporting

confidence: 93%

“…Approximately 50% of patients with pulmonary RGM disease in the present study had respiratory symptoms and no smoking history. Most of these results are concordant with the results in previous reports [5,8,19]. M. abscessus was found in 65% of pulmonary RGM disease, and the ratio of patients who met the diagnostic criteria to patients from whom RGM was isolated was highest in those patients with M. abscessus.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Pulmonary Disease Caused by Rapidly Growing Mycobacteria: A Retrospective Study of 44 Cases in Japan

Yano

Kitada²,

Mori³

et al. 2012

Respiration

View full text Add to dashboard Cite

Background: The features of pulmonary disease caused by rapidly growing mycobacteria (RGM) have not been sufficiently documented. Objectives: To establish these features, we retrospectively evaluated 44 patients. Methods: We screened respiratory isolates at the National Toneyama Hospital (Osaka, Japan) between 2003 and 2007. Diagnosis was based on the latest guidelines of the American Thoracic Society. The patients were classified into 3 types according to their radiographic findings: fibrocavitary, nodular bronchiectatic and unclassified variant. Results: We obtained 1,348 nontuberculous mycobacteria respiratory isolates from 1,187 patients, including 119 RGM isolates from 100 patients. Forty-four of these 100 patients were definitively diagnosed with respiratory disease due to RGM. The most common pathogen was Mycobacteriumabscessus, which accounted for 65.9% of cases, followed by Mycobacterium fortuitum at 20.5%. There was a statistically significant difference in smoking history between patients infected with these 4 RGM species (excluding those with an unknown smoking history; p = 0.039). The overall evaluation of radiographic findings revealed 18.2% as fibrocavitary, 43.2% as nodular bronchiectatic and 38.6% as unclassified variants in these 44 patients. There was a significant difference in radiographic findings between the 4 RGM species (p = 0.002). There was also a significant difference in radiographic findings between M. abscessus and M. fortuitum infected patients (p = 0.022). Conclusions: Patients with M. abscessus seem to have less of a smoking history and more frequent nodular bronchiectatic radiographic patterns than patients with M. fortuitum. In contrast, fibrocavitary patterns might be more frequent with M. fortuitum infection.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Pulmonary Disease Caused by Rapidly Growing Mycobacteria: A Retrospective Study of 44 Cases in Japan

Yano

Kitada²,

Mori³

et al. 2012

Respiration

View full text Add to dashboard Cite

show abstract

“…RGM, though traditionally believed to be non-pathogenic or opportunistic species, have emerged as significant human pathogens, causing various infections in healthy and immunocompromised hosts. 16 This underscores the importance of the accurate interpretation of findings on culture and the use of confirmatory tests. The recognition of RGM has significant implications for treatment purposes.…”

Section: Discussionmentioning

confidence: 99%

The microbiological diagnosis of tuberculosis in a resource - limited setting: is acid-fast bacilli microscopy alone sufficient?

Dada-Adegbola¹

2011

Ann. Ibadan Postgrad. Med.

View full text Add to dashboard Cite

The objective of this study is to audit the processes for the microbiological diagnosis of tuberculosis (TB) in our resource-limited setting. A total of 694 specimens were received from 333 patients. 129 (38.7%) of these patients were positive for TB. 78 (60.5%) were positive on AFB microscopy alone, 13 (10.0%) on culture alone and 38 (29.5%) on both culture and AFB microscopy. Fifty-one (51) cases were positive on culture, 38 of these (74.5%) had growth on Lowensen-Jensen culture medium alone, 11 (19.6%) on Pyruvic Acid Enhanced Medium (PAEM) and 3 (5.9%) on both culture media. AFB microscopy showed a diagnostic specificity of 71.6% and a sensitivity of 74.5%. M. Bovis appears to be prevalent and we suggest the need for speciation. If AFB microscopy is to be routinely used alone, without confirmation by culture, then the overriding need is for quality to be fully assured in its use.

show abstract

“…A clinical study on 115 cases infected with Rapidly Growing Mycobacteria showed M. abscessus to be the commonest NTM in 43 out of 113 (38.05%) cases and was most commonly isolated from the respiratory tract, 32/43 cases (74%); other sites being bloodstream, tissues and ascitic fluid, which made up the rest of the samples [11]. Due to intrinsic resistance to all the first line Anti-Tubercular drugs, M. abscessus infection is difficult to treat.…”

Section: Discussionmentioning

confidence: 99%

A Case of Meningitis Caused by Mycobacterium abscessus in a Paediatric Patient

Devi¹,

Mallikarjuna²,

Chaturvedi³

et al. 2015

JTR

View full text Add to dashboard Cite

Mycobacterium abscessus, a rapidly growing and potentially pathogenic Mycobacterium, is an environmental contaminant and is commonly found in tap water supplies. We report a case of M. abscessus meningitis following VP shunt insertion. A 9-year-old male patient with previous history of aqueductal stenosis and hydrocephalus with VP shunt in situ, presented with pain abdomen of 10 days duration. Investigations revealed multiple mesenteric lymph nodes with impacted VP shunt tip within the omentum. Ascitic fluid and CSF tap showed Acid-Fast Bacilli, later confirmed to be M. abscessus. The patient was treated with Clarithromycin and Amikacin, leading to resolution of the infection. To the best of our knowledge, this is the first reported case of M. abscessus meningitis in an immunocompetent individual. We discuss the possible sources of infection and therapeutic challenges. It is of utmost importance to consider, with high index of suspicion, nontubercular Mycobacteria as the causative organism in patients, who do not respond to regular anti-tubercular regimen.

show abstract

Rapidly Growing Mycobacteria

Cited by 132 publications

References 3 publications

Pulmonary Disease Caused by Rapidly Growing Mycobacteria: A Retrospective Study of 44 Cases in Japan

Pulmonary Disease Caused by Rapidly Growing Mycobacteria: A Retrospective Study of 44 Cases in Japan

The microbiological diagnosis of tuberculosis in a resource - limited setting: is acid-fast bacilli microscopy alone sufficient?

A Case of Meningitis Caused by Mycobacterium abscessus in a Paediatric Patient

Contact Info

Product

Resources

About